Pelvic radiotherapy does not deteriorate the quality of life of women with gynecologic cancers in long term follow-up: A two-year prospective single center study

Yavaş, Güler; Yavaş, Çağdaş; Dogan, Nasuh Utku; Ä°Lhan, T.T.; Karabağlı, Pınar; Doğan, Serdar; Ata, Ozlem; Yüce, Ebru; Çelık, Çetin

doi:10.1016/j.ygyno.2015.01.484

Cited by 6 publications

(12 citation statements)

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“…Uma vez caracterizados os efeitos adversos do tratamento radioterápico, bem como sua a repercussão na forma como as pacientes avaliam a QV durante o tratamento, é possível examinar as mudanças na avaliação da QV pelas pacientes no período posterior ao tratamento radioterápico. No ensaio clínico de Yavas et al 29 , foi analisada a QV de pacientes com câncer ginecológico imediatamente antes da radioterapia, pós-radioterapia e durante 24 meses de acompanhamento pós-radioterapia. Em suma, concluiu-se que nenhum efeito adverso significativo em longo prazo na QV geral dos pacientes resultou da radioterapia.…”

Section: Discussionunclassified

“…Por outro lado, foi constatada diminuição do prazer sexual e presença de disfunção sexual significativas. Esses dados corroboram o estudo de Yavas et al 29 , que mostrou redução dos níveis de ansiedade e depressão das pacientes ao longo do tempo. Esses autores 17 , no entanto, verificaram que as funções físicas e emocionais de mulheres submetidas à radioterapia adjuvante não melhoraram com o passar do tempo.…”

Section: Discussionunclassified

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Qualidade de Vida Associada ao Tratamento com Radioterapia em Mulheres Acometidas pelo Câncer do Colo do Útero: Revisão Integrativa da Literatura

Morais

Neto

Menezes

et al. 2021

Rev. Bras. Cancerol.

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Introdução: O câncer do colo do útero (CCU) está entre os cinco tipos de cânceres mais frequentes em mulheres. Inicialmente, o tratamento indicado é a cirurgia. Já, quando a paciente apresenta fatores de risco associados à recidiva local, é feita a radioterapia pélvica adjuvante. Investigar o impacto do tratamento na Qualidade de Vida (QV) das mulheres com CCU pode auxiliar o planejamento de ações no sentido de reduzir ou evitar danos. Objetivo: Compilar as repercussões e os fatores que influenciam a QV de mulheres com CCU submetidas ao tratamento radioterápico. Método: Foi realizada uma revisão integrativa da literatura nas bases de dados MEDLINE (PubMed), LILACS e SciELO. Os critérios de inclusão foram artigos dos últimos cinco anos, de acesso aberto, escritos em português, inglês ou espanhol e que abordassem o tema definido total ou parcialmente. Resultados: Foram selecionados 17 artigos, entre os quais predominaram os estudos longitudinais prospectivos (n=9), seguidos dos estudos transversais (n=5) e estudos longitudinais retrospectivos (n=3). Ademais, houve a utilização de 15 diferentes questionários, sendo mais frequente o European Organization for Research And Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30), que integrou oito estudos. Conclusão: A QV das mulheres submetidas à radioterapia foi influenciada por fatores socioeconômicos, educacionais, relações matrimoniais e modalidade da radioterapia. Apesar de os métodos de tratamento terem influenciado fatores individuais, como sintomas físicos e emocionais, não tiveram relação significativa com a QV geral. Estudos devem ser realizados para avaliar os efeitos da radioterapia em longo prazo.

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Section: Discussionunclassified

Qualidade de Vida Associada ao Tratamento com Radioterapia em Mulheres Acometidas pelo Câncer do Colo do Útero: Revisão Integrativa da Literatura

Morais

Neto

Menezes

et al. 2021

Rev. Bras. Cancerol.

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“…Chinese and Turkish works reported lower global health status among gynecologic cancer survivors who received wider area of radiation treatment. The wider radiation patients suffered more complications and thus reported lower global health status QoL than their peers (Wang et al,2015;Yavas et al, 2017). Larger radiation areas usually resulted in radiation cystitis, intra-abdominal adhesion which can cause bowel obstruction with possibility of bursting.…”

Section: Global Health Statusmentioning

confidence: 98%

“…Previous literature from Turkey reported that gynecologic cancer survivors (endometrial cancer plus other gynecological cancers) suffered from symptom scales as above mentioned during the first three months of cancer treatment. The symptoms subsided as time went by approaching two years after the treatment and resulted in nonsignificant presentation of the data (Yavas et al, 2017). A Chinese work by Wang and colleagues reported that symptom scales QoL (fatigue, dyspnea, insomnia and constipation) among gynecologic cancer with comorbidity were worse than those without comorbidity (Wang et al, 2015).…”

Section: Symptom Scalesmentioning

confidence: 99%

“…Our endometrial cancer survivor population were mainly more than 56 years old and mostly were facing retirement which would greatly alter their finances to a reduced income. Most literature about endometrial cancer survivors and their quality of life came from the European countries (Dobrzycka et al, 2017;Becker et al, 2011;de Boer et al,2015;Ferrandine et al, 2014;Yavas et al, 2017). Thai studies were needed to understand our population in our socioeconomic and cultural context in order to properly support our patients.…”

Section: Quality Of Lifementioning

confidence: 99%

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Comparative Study in Quality of Life between Thai Endometrial Cancer Survivors and Healthy Women in Thammasat University Hospital

Sivapornpan

Suwannarurk

Jaisin

et al. 2020

Asian Pac J Cancer Prev

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Endometrial cancer is a gynecologic malignancy that occurs in women most commonly in their sixth and seventh decade. Most cases had underlying diseases i.e., diabetes mellitus (DM), hypertension (HT) and dyslipidemia (DLP). It is a hormone dependent cancer with either unopposed estrogen condition or exogenous stimulation from tamoxifen (Dowdy et al., 2019).Endometrial cancer is the 6 th most commonly occurring cancer in women (Bray et al., 2018). In Thailand, endometrial cancer is the 9th most common form of female cancer with age standardized incidence rate of 4.3/100,000 women per year (Wilailak et al., 2016). AbstractBackground: This study aimed to survey quality of life (QoL) in endometrial cancer survivors between surgery with adjuvant therapy (radiation with or without chemotherapy) and surgery alone in Thammasat University Hospital, Thailand. Materials and Methods: This cross-sectional study was conducted at the Gynecologic Oncology clinic, Thammasat University hospital, Thailand between March 2011 and May 2019. Participants were endometrial cancer cases who underwent surgical staging with or without adjuvant treatment (study) and healthy women who came to gynecologic department for annual cervical screening (control). Assessment of QoL was investigated via the structural questionnaire designed by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 (Thai version). Results: During the period of the study, 94 participants who were diagnosed with endometrial cancer and underwent surgical staging were enrolled. There were 51, 43 and 51 cases in group A (surgery with adjuvant therapy), group B (surgery only) and group C (control), respectively. Control cases were participants who had comparable demographic characteristics and underwent gynecological checkup during the period of study. In part of physical functioning, group B had statistically better scores than group A. Participant in group B and C reported significantly better QoL in part of social functioning than group A. Symptom severity; appetite loss and constipation in group B was statistically less than in group A. Constipation problems in group A and C were comparable. Participants in group C had worse global health status than group A/B. Conclusion: Adjuvant treatment with either radiation or chemotherapy had negative impacts on QoL in endometrial cancer survivors. It impacted physical health, social function, appetite loss, and constipation. All endometrial cancer survivors had global health scores better than healthy peers. Thoroughly counseling to endometrial cancer survivors remains an important tool for increasing awareness of treatment complications and lowering psychological emotional stress.

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Symptom burden, psychological distress, and health-related quality of life in cancer survivors with pelvic late radiation tissue injuries

Velure

Müller

Hauken

2021

Support Care Cancer

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Purpose Curative radiotherapy for cancer may lead to severe late radiation tissue injuries (LRTIs). However, limited knowledge exists about pelvic cancer survivors’ LRTI symptoms, distress, and health-related quality of life (HRQOL). We sought to assess the symptom burden, distress, and HRQOL in survivors with established pelvic LRTIs compared to norm populations and to investigate the relation between these factors. Methods Cancer survivors referred for treatment of established pelvic LRTIs were recruited nationwide. LTRIs were assessed with the Expanded Prostate Cancer Index Composite (EPIC), psychological distress was assessed with the General Health Questionnaire (GHQ-12), and HRQOL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORCT-QLQ-C30). Results A total of 107 participants (mean age 64, 53% men) were included. Compared to norms, participants reported more urinary (mean 68.7 vs. 89.5; p = 0.00; d = 1.4) and bowel symptoms (mean 62.5 vs. 92.4; p = 0.00; d = 2.7), increased psychological distress (mean 13.4 vs. 10.3; p = 0.00; d = 0.6), and overall poorer HRQOL (mean 54.9 vs. 71.2; p = 0.00; d = 0.7). Higher symptom burden and higher levels of psychological distress were associated with lower HRQOL (r2 = 46%), but psychological distress did not moderate the influence of symptoms on HRQOL. Conclusion Cancer survivors with established pelvic LRTIs are highly burdened compared to norms. The association of the LRTI-related symptom burden with HRQOL is independent of the level of psychological distress. Both coping and treatment interventions are crucial to promoting long-term health and HRQOL. Trial registration NCT03570229.

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Pelvic radiotherapy does not deteriorate the quality of life of women with gynecologic cancers in long term follow-up: A two-year prospective single center study

Cited by 6 publications

References 0 publications

Qualidade de Vida Associada ao Tratamento com Radioterapia em Mulheres Acometidas pelo Câncer do Colo do Útero: Revisão Integrativa da Literatura

Qualidade de Vida Associada ao Tratamento com Radioterapia em Mulheres Acometidas pelo Câncer do Colo do Útero: Revisão Integrativa da Literatura

Comparative Study in Quality of Life between Thai Endometrial Cancer Survivors and Healthy Women in Thammasat University Hospital

Symptom burden, psychological distress, and health-related quality of life in cancer survivors with pelvic late radiation tissue injuries

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