Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes

Abstract

Onset of PG in the first or second trimester and presence of blisters may lead to adverse pregnancy outcomes including decreased gestational age at delivery, preterm birth, and LBW children. Such pregnancies should be considered high risk and appropriate obstetric care should be provided. Systemic corticosteroid treatment, in contrast, does not substantially affect pregnancy outcomes, and its use for PG in pregnant women is justified.

Pemphigoid gestationis: A Moroccan study

“…The risk of preterm birth and fetal growth restriction is greater in PG pregnancies compared to normal population [24,25]. The pregnancy risks of PG are thought to be associated with mild placental failure caused by BP180 antibodies [25,26].…”

“…The pregnancy risks of PG are thought to be associated with mild placental failure caused by BP180 antibodies [25,26]. In addition to accumulation of C3 complement and IgG, mild villitis and collections of immature fibrotic villi have been observed in histologic examinations of PG placentas [27].…”

“…In addition to accumulation of C3 complement and IgG, mild villitis and collections of immature fibrotic villi have been observed in histologic examinations of PG placentas [27]. Antibody concentrations do not as such correlate with the occurrence of pregnancy complications, and no association has been demonstrated between cortisone treatment and PG pregnancy complications [25]. No follow-up guidelines for pregnancies complicated by PG have been published, most likely due to the rarity of the condition.…”

A view of the problem of pregnancy-specific skin dermatoses. Part I

“…В последнем триместре беременно-сти состояние больной улучшается (особенно при раннем начале процесса), однако во время родов в 75% случаев снова резко ухудшается. В первые не-дели после родов или после прерывания беременно-сти клинические манифестации спонтанно ослабе-вают и повторяются во время каждой последующей беременности (возможны также во время менстру-ального цикла, применения гормональных контра-цептивов) [26,29,30,34].…”

Pemphigoid gestationis – a rare dermatosis of the prenatal period. Case report

“…A correlation has been found between the presence of PG and IUGR. Data on such correlation are of low diagnostic value, but they indicate the need for careful fetal monitoring in that group of patients [13].…”