Pemphigus and depression comorbidity: a case control study

Wohl, Yonit; Mashiah, Jacob; Kutz, Ana; Hadj‐Rabia, Smail; Cohen, Arnon D.

doi:10.1684/ejd.2015.2649

Cited by 29 publications

(52 citation statements)

References 26 publications

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“…Studies also indicated that duration of smoking and number of cigarettes smoked were significantly lower in patients with pemphigus than controls and that remission may be achieved sooner in those who smoke . A generally low prevalence of smoking of 15.3–42.3% (mean 23%) was found in patients with pemphigus, but the smoking status was not further specified as current and/or former in six studies . Some investigations demonstrated no significant difference regarding the smoking status compared with non‐pemphigus subjects, in whom the prevalence of smoking was 7.1–48.5% (mean 29%) .…”

Section: Resultsmentioning

confidence: 99%

“…A total of 31 different citation hits related to the terms used in the electronic literature search were retrieved. After critical screening of titles, abstracts and full text, 13 articles with a total of 3046 patients with pemphigus, conducted in 10 countries, were suitable in this review . The characteristics of each individual study associated with cigarette smoking and pemphigus are shown in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Diagnosis of pemphigus was based on characteristic clinical disease features confirmed by histopathologic and/or direct immunofluorescence microscopic analysis, with only two studies reporting additional immunoserological testing, whereas diagnostic criteria were not mentioned in three studies . The analysed cohorts were patients with PV (24.5%) and PF (1.6%), while the rest represented partly unspecified types of pemphigus . The male/female ratio was 1 : 1.4, and the mean age and disease duration ranges were 32.3–72.1 years and 2.5 months to 8.64 years, respectively, although length of symptoms was not reported in five studies .…”

Section: Resultsmentioning

confidence: 99%

“…The analysed cohorts were patients with PV (24.5%) and PF (1.6%), while the rest represented partly unspecified types of pemphigus . The male/female ratio was 1 : 1.4, and the mean age and disease duration ranges were 32.3–72.1 years and 2.5 months to 8.64 years, respectively, although length of symptoms was not reported in five studies . Considering the treatment of patients, two articles reported no pharmacological intervention during the study, and six studies did not inform about or specify the drug therapy .…”

Section: Resultsmentioning

confidence: 99%

“…Considering the treatment of patients, two articles reported no pharmacological intervention during the study, and six studies did not inform about or specify the drug therapy . In the remainder of the studies, medications included corticosteroids, azathioprine, cyclophosphamide, dapsone, gold compounds, anabolic steroids and antibiotics …”

Section: Resultsmentioning

confidence: 99%

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Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature

Lai

Recke

Zillikens

et al. 2018

Acad Dermatol Venereol

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Epidemiological evidence suggests that smoking cigarettes may be beneficial in pemphigus, but no systematic evaluation exists to corroborate this assumption. Therefore, a systematic literature review with pooled data analysis of the smoking status in patients with pemphigus was conducted. Electronic searches using PubMed from inception to November 2017 identified 13 reports meeting predetermined inclusion and exclusion criteria. Most were case-control studies partly reporting that pemphigus vulgaris and foliaceus occurred less frequently in current and former smokers. Studies also indicated that duration of smoking and number of cigarettes smoked were lower in patients with pemphigus than controls and that remission may be achieved sooner in those who smoke. However, although a generally low prevalence of smoking was demonstrated in patients with pemphigus, which was lower than in controls by pooled analysis, some investigations found no difference regarding the smoking status compared with non-pemphigus subjects. One study demonstrated more severe mucosal involvement in non-smoking patients with pemphigus, whereas another observed no difference in the rate of cutaneous or mucosal lesions between smokers and non-smokers with pemphigus. This review indicates that smoking may be a possible protective factor in pemphigus, although some compromised study methodologies yet hinder any firm conclusion. Further investigations with a refined quality design are required to resolve the so far partly conflicting results in this area.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature

Lai

Recke

Zillikens

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

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Bullous Dermatoses and Depression

et al. 2021

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ullous diseases affecting the skin and mucosa can have a substantial role in patients' quality of life and mental health. The most common bullous dermatoses include bullous pemphigoid and pemphigus vulgaris, which have an incidence of 4.3 and 0.1 to 0.7 per 100 000 persons worldwide, respectively. 1,2 Bullous pemphigoid and pemphigus vulgaris are both autoimmune bullous dermatoses, with antibodies to hemidesmosomes and desmoglein, respectively. 3 Epidermolysis bullosa (EB) is an inherited disorder caused by either autosomal dominant or recessive variants in genes that code structural proteins. Overall, bullous dermatoses are associated with substantial morbidity and mortality. Specifically, bullous dermatoses are associated with an increased risk of cardiovascular disease, 4 neurologic disease, 5 other autoimmune diseases, 6 and a negative outcome on quality of life. 7 Approximately 1 in 3 patients with skin disease experience depression,anddepressionhasbeenassociatedwithlowermedicationadherence and worsening disease severity among dermatology patients. 8,9 Patients with bullous skin diseases may be especially susceptible to developingmentalhealthcomorbiditiesowingtothechronicphysicaland emotional outcomes of these diseases. However, there is a critical lack of evidence synthesis on the prevalence of depression among patients with bullous skin diseases. This systematic review aims to synthesize andinterpretthecurrentevidenceondepressionanddepressivesymptoms among patients diagnosed with bullous dermatoses. Methods Search Strategy and Study SelectionIn conducting this review, we followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. 10 We conducted searches of the PubMed, Embase, Cochrane, and PsycInfo databases in February 2021. This systematic review was prospectively registered with PROSPERO (CRD42021230750). Database searches included articles published between 1945 and February 2021 using MeSH search terms ("Skin Diseases, Vesiculobullous" [MeSH] AND "Depression" [MeSH]), as appropriate. The initial database searches yielded a total of 271 results (Figure).Two team members, S.P.P. and Y.G., reviewed the titles and abstracts of the articles and applied inclusion and exclusion criteria to determine eligibility for this review. We also reviewed reference lists of relevant articles. For this review, inclusion criteria included patients of all ages diagnosed with bullous skin disease who were screened for depression or diagnosed with depression. Articles without primary data, case reports, and those not limited to human study were excluded. All discrepancies were mediated by A.W.A. After reviewing article titles and abstracts, S.P.P. and Y.G. determined that 36 were eligible for full-text review. IMPORTANCE There is a lack of evidence synthesis on the association between bullous skin disease and depression.OBJECTIVE To synthesize and interpret the current evidence on the association between bullous skin disease and depression.EVIDENCE REVIEW This review was co...

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The role of sleep in pemphigus: a review of mechanisms and perspectives

et al. 2017

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Pemphigus is an autoimmune bullous disease that causes the development of blisters and erosions on the skin and/or mucosa. Its inflammatory process is mediated by cytokines, which interact with sleep in a bidirectional manner. Pain, a frequent symptom due to pemphigus lesions, is well known to impair sleep quality. Depression is also associated with pemphigus and pro-inflammatory cytokines and may impair sleep. Additionally, a common relationship among other dermatological diseases and sleep has increasingly been described. Poor sleep quality is associated with an increased risk for autoimmune diseases, and insomnia is a comorbidity that has recently been associated with pemphigus. Thus, this review will explore the evidence supporting the likely bidirectional relationship between pemphigus and sleep quality and its possible mechanisms involved. This approach covering both pemphigus and sleep will open a research avenue for future studies focusing on the efficacy of the sleep disorders treatment in patients with pemphigus. In the long term, this may provide relevant information to dermatologists regarding new strategies for the management of pemphigus clinical condition, allowing possibly a better quality of life for the patients.

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Pemphigus and depression comorbidity: a case control study

Cited by 29 publications

References 26 publications

Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature

Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature

Bullous Dermatoses and Depression

The role of sleep in pemphigus: a review of mechanisms and perspectives

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