Pemphigus can be induced by topical phenol as well as by foods and drugs that contain phenols or thiols

Brenner, Sarah; Srebrnik, A; Goldberg, Ilan

doi:10.1111/j.1473-2130.2004.00098.x

Cited by 17 publications

(18 citation statements)

References 33 publications

(49 reference statements)

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“…It was suggested that several factors, such as phenols or thiols, may induce acantholysis and trigger auto-immune pemphigus [23]. Organophosphate pesticides were shown to block the acetylcholinesterase channel [24].…”

Section: Discussionmentioning

confidence: 99%

Incidence of Auto-Immune Pemphigus in the Midi-Pyrénées Region in 2002–2006

et al. 2009

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Introduction: Auto-immune pemphigus is an organ-specific immune disorder due to pathogenic auto-antibodies. Both genetic and environmental factors have been associated with the occurrence of auto-immune pemphigus. Little is known about the epidemiology of auto-immune pemphigus in western Europe. Objective: To evaluate the incidence of auto-immune pemphigus in south-western France (namely the Midi-Pyrénées region) in a 5-year period between 2002 and 2006. Materials and Methods: We performed a retrospective study of the annual incidence of auto-immune pemphigus diagnosed in the Midi-Pyrénées region, between January 1, 2002, and December 31, 2006. Possible cases of pemphigus were initially selected using skin direct immunofluorescence (DIF) databases from all laboratories in the Midi-Pyrénées region. Systematic validation of all cases was performed by two of the authors (N.M., M.T.). To qualify as a case of auto-immune pemphigus, patients had to fulfil the following criteria: history of clinical signs of pemphigus as assessed by a dermatologist and a positive DIF. To be included in the study, validated cases of auto-immune pemphigus had to fulfil the following criteria: the date of first positive skin DIF between January 1, 2002, and December 31, 2006, and patient living in the Midi-Pyrénées region at the time of the first positive skin DIF. Results: Between 2002 and 2006, 91 patients with positive DIF were identified. Fifty-four patients with positive DIF did not meet the validation criteria for the study. Thirty-seven cases were included in the analysis. The crude annual mean incidence of auto-immune pemphigus between 2002 and 2006 was 2.7 cases/10⁶ inhabitants/year (95% CI: 1.87–3.69). The world-population-standardized annual mean incidence of auto-immune pemphigus was 1.55 (95% CI: 0.99–2.11). Conclusion: We report a 1.55/10⁶ inhabitants/year world-population-standardized incidence of auto-immune pemphigus in the south-west of France. A nationwide epidemiological study of pemphigus should be performed in France.

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Section: Discussionmentioning

confidence: 99%

Incidence of Auto-Immune Pemphigus in the Midi-Pyrénées Region in 2002–2006

et al. 2009

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“…Phenol derivatives were reported to induce acantholysis both in vitro and in vivo , after topical application and consumption [24, 40, 41]. The role of polyphenolic compounds – tannins, contained in food or water, was suggested in research articles and case reports describing fogo selvagem (“wild fire”) endemic PF [41–45].…”

Section: Discussion Of the Issue Of Pemphigus Triggering In Relation mentioning

confidence: 99%

“…Thiol compounds or mercaptans cause acantholysis in vivo and in vitro in cultured tissues [20, 40, 55]. Thiol-mediated cell-cell adhesion loss seem to be caused by direct biochemical aberration of desmosome structure itself, e.g.…”

Section: Discussion Of the Issue Of Pemphigus Triggering In Relation mentioning

confidence: 99%

Reviewing putative industrial triggering in pemphigus: cluster of pemphigus in the area near the wastewater treatment plant

Pietkiewicz

Gornowicz‐Porowska

Bartkiewicz

et al. 2017

pdia

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A range of pemphigus is relatively rare potentially fatal group of autoimmune blistering dermatoses. Usually, there is no apparent triggering, while in some predisposed patients there are alleged environmental/industrial inducing factors. In a short time period (4 years), we diagnosed 3 novel cases of pemphigus (1 pemphigus vulgaris, 1 pemphigus foliaceus and 1 shift from pemphigus foliaceus into pemphigus vulgaris) at a clinical and laboratory level (ELISA, immunofluorescence studies). We discuss a possible common inducing mechanism as these patients inhabit one estate of the Poznan suburbia (Kozieglowy, population < 12,000), Greater Poland district, Poland, and review literature data on alleged pemphigus triggers. To the best of our knowledge, this is the first report exploring the putative association between pemphigus diseases and wastewater treatment plant waterborne or volatile by-products in the vicinity of such a facility.

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“…15 On üç pemfiguslu hasta üzerinde yapılan bir çalışmada 12 hastanın hastalık ortaya çıkmadan önceki bir yıl içinde stresli yaşam olaylarına maruz kaldığı gösterilmiştir. 16 Bizim çalışmamızda kontrol grubu ile yapılan karşılaştırma sonucunda bazı stresli olayların hasta grubunda istastistiksel olarak anlamlı ölçüde (p<0,01) yüksek oranda yaşandığı tespit edildi. Hastaların beslenme alışkanlıklarını araştırmaya yönelik, çay, kahve, acı ve baharatlı yiyecek yeme alışkanlıkları sorgulandığında, her iki grupta da çayın fazla miktarda tüketildiği, acı ve baharatlı yiyeceklerin az oranda yenildiği görüldü.…”

Section: Discussionunclassified

Pemfigusta Risk Faktörleri

Demirci¹,

Mansur²,

Aydıngöz³

2011

TURKDERM

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ÖzetAmaç: Pemfigusun ortaya çıkmasında ve hastalığın seyrinde bazı dış faktörlerin etkili olduğu üzerinde durulmaktadır. Bu araştırma-da pemfigus tanısı ile takip ettiğimiz hastalarda hastalığın etyolojisinde rol oynayabilecek faktörlerin araştırılması amaçlanmıştır. Gereç ve yöntem: Kliniğimizde 1998-2004 yılları arasında histopatolojik ve direkt immunofloresan incelemeler ile pemfigus tanı-sı konan 15'i erkek, 27'si kadın toplam 42 hasta, demografik özellikler, meslek grubu, eğitim düzeyi, hastalığın ortaya çıkmadan önceki süreçte geçirilmiş stresli yaşam olayları, gebelik sayısı, diyet, sigara ve alkol alışkanlığı gibi etkenler açısından sorgulanarak benzer sosyoekonomik düzeye sahip, aynı yaş ve cinsiyetteki bir kontrol grubuyla karşılaştırıldı. Bulgular: Hayvancılık ve tarım ile uğraşmanın, gebelik sayısının fazla oluşunun, sigara içmemenin ve psikolojik stresin pemfiguslu hastalarda kontrol grubuna göre istatistiksel olarak anlamlı oranda yüksek bulunduğu saptandı. Sum maryBackground and Design: There have been reports suggesting the involvement of environmental factors in the disease process of pemphigus. In this study, we aimed to find out the risk factors which could play role in the etiopathogenesis in our pemphigus patients. Material and method: A total of 42 patients (15 male and 27 female) who were diagnosed as pemphigus with histopathological and direct immunoflurosence examinations in our clinic between the years 1998-2004, were interviewed for assessment of regarding with the subjects of the demographic properties, occupational groups, educational level, the number of pregnancies, stressfull life events, diet habits, smoking and alcohol consumption before the onset of the disease and the results were compared to 42 age and gender-matched controls with similar socioeconomic circumstances. Results: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were found to be statistically significant in pemphigus patients than in controls. Conclusion: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were assumed to play role in the etiopathogenesis and course of pemphigus. (Turk derm 2011; 45: 140-5)

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Pemphigus can be induced by topical phenol as well as by foods and drugs that contain phenols or thiols

Cited by 17 publications

References 33 publications

Incidence of Auto-Immune Pemphigus in the Midi-Pyrénées Region in 2002–2006

Incidence of Auto-Immune Pemphigus in the Midi-Pyrénées Region in 2002–2006

Reviewing putative industrial triggering in pemphigus: cluster of pemphigus in the area near the wastewater treatment plant

Pemfigusta Risk Faktörleri

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