Pencil and paper

Wong, Bang; Kjærgaard, Rikke Schmidt

doi:10.1038/nmeth.2223

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…My quest to find a practical solution to the problem of population age structure estimation led to the discovery of the basic stationary population identity. A second lesson pertains to the virtues of pencil-and-paper modelling in science -it is both immediate and simple (Wong and Kjaergaard, 2012). This step forced me to think about the essence of the problem rather than becoming buried in its complexities.…”

Section: Concluding Thoughtsmentioning

confidence: 99%

16. Ageing in the Wild, Residual Demography and Discovery of a Stationary Population Equality

Carey

2024

Human Evolutionary Demography

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In the late 1990s while exploring methods for estimating population age structure using the post-capture longevity of fruit flies sampled from the wild (referred to as residual demography) I discovered an identity in which the fraction of individuals x days old in a stationary population equals the fraction that die x days later. I co-authored a paper containing this identity in 2004 as part of a larger publication with my biodemography colleagues where we extended the concept for practical application. In 2009 demographer James Vaupel published a proof of this identity and referred to it using the eponym Carey’s Equality. The Vaupel paper was then followed six years later (2015) by a surprise—the identity had been published in French 30 years earlier in the gray literature by demographer Nicolas Brouard. Remarkably the identity had never been cited in either the searchable (journal) literature or in any of the mainstream demography texts, treatises, encyclopedias or reference books. Here I tell the story of how I discovered this identity, why it is important, implications for human demography, and lessons learned along the way.

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Section: Concluding Thoughtsmentioning

confidence: 99%

16. Ageing in the Wild, Residual Demography and Discovery of a Stationary Population Equality

Carey

2024

Human Evolutionary Demography

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“…Hand-drawn sketches continue to be useful in science. As succinctly described by Wong and Rikke 19 , and building on a lively literature describing the place of sketching in design 20, 21 , quick sketches have many advantages (Figure 6). They are immediate and require minimal materials or training, so the barrier is low to get started.…”

Section: Current Techniques In 2d Molecular Illustrationmentioning

confidence: 99%

Molecular Illustration in Research and Education: Past, Present, and Future

Goodsell

Jenkinson

2018

Journal of Molecular Biology

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Two-dimensional illustration is used extensively to study and disseminate the results of structural molecular biology. Molecular graphics methods have been and continue to be developed to address the growing needs of the structural biology community, and there are currently many effective, turn-key methods for displaying and exploring molecular structure. Building on decades of experience in design, best-practice resources are available to guide creation of illustrations that are effective for research and education communities.

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“…Methods of cellular tomography provide the most detailed experimental view of this level with many successes in the localization of larger macromolecules (such as ribosomes) within whole cells 1 , 2 . However, an atomic resolution view of this intermediate scale, in spite of its utility in hypothesis generation, science communication, and simulation, remains sparsely modeled and visualized compared to larger and smaller scales of study 3 – 5 .…”

Section: Introductionmentioning

confidence: 99%

cellPACK: a virtual mesoscope to model and visualize structural systems biology

et al. 2014

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cellPACK assembles computational models of the biological mesoscale, an intermediate scale (10−7–10−8m) between molecular and cellular biology. cellPACK’s modular architecture unites existing and novel packing algorithms to generate, visualize and analyze comprehensive 3D models of complex biological environments that integrate data from multiple experimental systems biology and structural biology sources. cellPACK is currently available as open source code, with tools for validation of models and with recipes and models for five biological systems: blood plasma, cytoplasm, synaptic vesicles, HIV and a mycoplasma cell. We have applied cellPACK to model distributions of HIV envelope protein to test several hypotheses for consistency with experimental observations. Biologists, educators, and outreach specialists can interact with cellPACK models, develop new recipes and perform packing experiments through scripting and graphical user interfaces at http://cellPACK.org.

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Pencil and paper

Cited by 7 publications

References 1 publication

16. Ageing in the Wild, Residual Demography and Discovery of a Stationary Population Equality

16. Ageing in the Wild, Residual Demography and Discovery of a Stationary Population Equality

Molecular Illustration in Research and Education: Past, Present, and Future

cellPACK: a virtual mesoscope to model and visualize structural systems biology

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