Pengaruh Krim Asam Traneksamat terhadap Pembentukan Keriput dan Kadar Matriks Metaloproteinase-1 pada Mencit (Mus Musculus) Jantan Galur Balb/c yang Dipajan Sinar Ultraviolet B

Citrawan, Andrew; Suwarsa, Oki; Gunawan, Hendra; Adi, Sudigdo; Lesmana, Ronny; Achadiyani, Achadiyani; Adi, Sunaryati S.

doi:10.15416/ijcp.2019.8.2.121

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…[42] Giving tranexamic acid cream with a concentration of 3%, 4%, and 5% can slow the formation of wrinkles and reduce levels of MMP-1. [43] Use a night cream containing AHA, BHA, retinol, vitamin A, a combination of niacinamide, resveratrol, and hexylresorcinol, and a day cream containing SPF to prevent photoaging.…”

Section: Discussionmentioning

confidence: 99%

High Serum Level of Matrix Metalloproteinase-1 (MMP-1) Correlates Positively with The Severity of Photoaging Facial Wrinkles

Tirka¹,

Praharsini²,

Karmila³

et al. 2023

International Journal of Scientific Advances

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Background: Matrix metalloproteinase-1 was chosen in this study because it is a subgroup of MMPs that play an essential role in the photoaging process of collagenases with degradation of collagen types 1 and 2 as a result of direct UVA and UVB exposure with significantly increased regulation of these exposures compared to other types of MMPs. The purpose of this study is to prove a positive correlation between high MMP-1 serum levels and the severity of facial wrinkles in photoaging subjects. Methods: Observational analytic study using a cross-sectional approach with comparative analysis aims to determine differences in the severity of facial wrinkles in patients experiencing Photoaging based on MMP-1 levels. Subjective clinical observation of wrinkles with Glogau score and objective use of the A-One-Facial Analyzer tool. Analyzing using SPSS 26. Results: 51 subjects were divided into two groups, 30 photoaging, and 21 non-photoaging. The results of the A-One-Facial Analyzer Photoaging group were 5.30 (4.70-6.50) and without Photoaging were 4.80 (4-5). MMP-1 serum levels in the Photoaging group median of 17.69 (9.78-84.07) pg./ml and non-photoaging group 11.56 (8.07-19.62) pg/ml (p <0.001). Spearman Rho test between MMP-1 levels and wrinkles on the face obtained a moderate positive relationship with a correlation coefficient value (r) of 0, 5 and p-value <0.001. The result of the coefficient β was 41,5%, R-square 48%, and it was statistically significant with p = 0.002. Conclusion: High serum levels of matrix metalloproteinase -1 (MMP-1) have a positive correlation with the severity of facial skin wrinkles that experience Photoaging.

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Section: Discussionmentioning

confidence: 99%

High Serum Level of Matrix Metalloproteinase-1 (MMP-1) Correlates Positively with The Severity of Photoaging Facial Wrinkles

Tirka¹,

Praharsini²,

Karmila³

et al. 2023

International Journal of Scientific Advances

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“…11 Indikasi umum asam traneksamat yaitu digunakan dalam pencegahan dan pengobatan perdarahan. 12 Dalam penelitian Myles 13 juga dibuktikan bahwa asam traneksamat dapat mengurangi jumlah perdarahan pada pasien bedah koroner yang menggunakan aspirin. 13 Waktu perdarahan pada kelompok perlakuan satu lebih pendek dibandingkan dengan kelompok kontrol negatif, akan tetapi tidak lebih pendek dari kelompok kontrol positif dan kelompok perlakuan dua.…”

Section: Pembahasanunclassified

Pengaruh ekstrak bagian dalam kulit durian terhadap waktu perdarahan pada luka potong ekor mencit: Studi eksperimental in vitro

Ihsaniyah,

Yuwono,

Budirahardjo

2023

J Ked Gi Unpad

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untuk open akses publikasi dibawah syarat dan ketentuan dari Creative Commons Attribution (CC BY) license (https: // creativecommons.org/licenses/by/ 4.0/).ABSTRAK Pendahuluan: Pencabutan gigi mengakibatkan perdarahan pada gingiva dan mukosa rongga mulut yang dapat menyebabkan komplikasi. Perdarahan dapat diminimalisir dengan suatu zat untuk hemostasis. Kulit durian mengandung beberapa senyawa aktif yang digunakan untuk mempercepat hemostasis yang dapat mempengaruhi waktu perdarahan. Sehingga diperlukan penelitian untuk menganalisis pengaruh ekstrak bagian dalam kulit durian (durio zibethinus murr.) terhadap waktu perdarahan luka potong ekor mencit (Mus musculus). Tujuan penelitian untuk menganalisis pengaruh pemberian ekstrak bagian dalam kulit durian terhadap waktu perdarahan pada luka potong ekor mencit. Metode: Jenis penelitian eksperimental laboratoris dengan rancangan posttest-only control group design. Sampel adalah 20 ekor mencit yang dibagi 4 kelompok yaitu, kelompok kontrol negatif (aquades steril), kelompok kontrol positif (asam traneksamat), dan dua kelompok perlakuan (ekstrak bagian dalam kulit durian dengan dosis 100 dan 200 mg/kg BB). Tahap selanjutnya pemotongan ekor mencit, kemudian dilakukan perhitungan waktu perdarahan dan analisis data. Data hasil penelitian diuji normalitasnya menggunakan uji Shapiro Wilk dan uji homogenitas menggunakan Levene test. Selanjutnya uji One Way Anova dan uji LSD. Hasil: Waktu perdarahan kelompok kontrol negatif yaitu 7 menit, kelompok kontrol positif yaitu 2,5 menit, kelompok perlakuan satu yaitu 4,9 menit, dan pada kelompok perlakuan dua yaitu 3 menit. Hasil uji One Way Anova terdapat perbedaan waktu perdarahan pada semua kelompok. Hasil uji LSD terdapat perbedaan yang bermakna antara kelompok perlakuan. Hasil uji terlihat bahwa semakin tinggi dosis yang diberikan maka waktu perdarahan semakin pendek. Simpulan: pemberian ekstrak bagian dalam kulit durian (Durio zibethinus Murr.) dapat memperpendek waktu perdarahan. Kata kuncihemostasis, ekstrak, kulit durian, waktu perdarahan, luka Effect of durian skin extract on bleeding time in mice tail cut wounds: experiment study ABSTRACT Introduction:Tooth extraction often leads to gingiva and oral mucosa bleeding, which may give rise to complications. To mitigate bleeding, hemostatic agents are employed. The inner bark of the durian fruit (Durio zibethinus murr.) contains several active compounds known to accelerate hemostasis and influence bleeding time. Thus, there is a need for research to analyze the impact of the extract obtained from the inner bark of durian on the bleeding time of cut wounds on the tails of mice (Mus musculus). Purpose: To examine the impact of administering extracts from the inner portion of the durian peel on the bleeding time in tail incisions of mice. Methods: This study employed a laboratory experiment with a posttest-only control group design. The sample size consisted of 20 mice, divided into four groups: the negative control group (treated with sterile distilled water), the positive control...

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“…This research is referred to as the modification of Citrawan et al (2019) and Rahmi et al (2013). The anti-wrinkle test aims to observe the effect of three essential oil combinations mixed with olive oil on rat-induced UVB irradiation.…”

Section: Anti-wrinkle Parametermentioning

confidence: 99%

Components Analysis of Bioactive Essential Oil Combinations (Lavender, Lemon, and Cinnamon) by Gas Chromatography-Mass Spectrometry and their Activities against In Vitro Photoaging on Hairless Rat Dorsal Skin

et al. 2022

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The essential oil of lavender, lemon, and cinnamon (LaLC) combination is rich in antioxidants and potentially be used as an anti-wrinkle and strengthens the collagen tissue. Ultraviolet B (UVB) radiation is a free radical source that accelerates the aging process and reduces collagen production. This study aims to characterize the chemical components of each oil and determine the best combination as an anti-wrinkle substance. The test was conducted on twenty-four Wistar male rats (Mus musculus) that were divided into six experimental groups consisting of the normal (N), control (C), vehicle control (V), first treatment (T1), second treatment (T2), and third treatment (T3) groups. Each sample was rubbed upon, and the UVB irradiation was administered frequently to each subject. The embedded skin specimen was analyzed using a digital-capable microscope. Data were analyzed through the Kolmogorov-Smirnov normality test, one-way analysis of variance (ANOVA), and the post-hoc Tukey's Honest Significant Difference test. Lavender, lemon, and cinnamon essential oils contained each most significant component, which was linalool (41.46% peak area), dl limonene (44.74% peak area), and 2-propenal, 3-phenyl- (CAS) (53.89% peak area), respectively according to the Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The T1 showed the best score of all parameters and did not show significant significance compared to the N group. In conclusion, the 1:1:3 combination of LaLC is better in preventing in vitro photoaging than other treatment groups.

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Pengaruh Krim Asam Traneksamat terhadap Pembentukan Keriput dan Kadar Matriks Metaloproteinase-1 pada Mencit (Mus Musculus) Jantan Galur Balb/c yang Dipajan Sinar Ultraviolet B

Cited by 3 publications

References 21 publications

High Serum Level of Matrix Metalloproteinase-1 (MMP-1) Correlates Positively with The Severity of Photoaging Facial Wrinkles

High Serum Level of Matrix Metalloproteinase-1 (MMP-1) Correlates Positively with The Severity of Photoaging Facial Wrinkles

Pengaruh ekstrak bagian dalam kulit durian terhadap waktu perdarahan pada luka potong ekor mencit: Studi eksperimental in vitro

Components Analysis of Bioactive Essential Oil Combinations (Lavender, Lemon, and Cinnamon) by Gas Chromatography-Mass Spectrometry and their Activities against In Vitro Photoaging on Hairless Rat Dorsal Skin

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