Penicillin G as Electrolyte and Colloidal Electrolyte

McBain, James W.; Brady, A. P.

doi:10.1021/ja01169a515

Cited by 28 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Penicillin G has been ascribed a cmc by some authors (e.g. Hauser, Phillips & others, 1949;McBain, Huff & Brady, 1949;Thakkar & Wilham, 1970), whereas others (e.g. Lund & Pedersen-Bjergaard, 1949;Goyan, 1949;Hocking, 1951;Few & Schulman, 1953), have not observed surface activity.…”

Section: Surface Tensionmentioning

confidence: 99%

The diffusion of penicillin G and ampicillin through phospholipid sols

Padfield

Kellaway

1975

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

The self-diffusion coefficients of penicillin G and ampicillin have been determined at 25" in water and in the presence of a swamping concentration of electrolyte. The antibiotics diffused through phospholipid dispersions at a reduced rate due to interaction with the lipid aggregates. Ampicillin diffused through the phosphatidylcholine and phosphatidylethanolamine dispersions more rapidly than penicillin G, whereas the latter diffused more rapidly through the lysophosphatidylcholine dispersions. Estimates of binding have been made from these data and compared with those obtained from equilibrium dialysis studies. Surface tension measurements indicated that the antibiotics exhibited minimal surface activity. These results have been correlated with data obtained in other studies and a possible explanation has been advanced for the reported differences in in vivo activity of penicillin G and ampicillin.

show abstract

Section: Surface Tensionmentioning

confidence: 99%

The diffusion of penicillin G and ampicillin through phospholipid sols

Padfield

Kellaway

1975

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…We have recently reported the influence of electrolyte on the mode of association, micellar properties, and intermicellar interactions of cloxacillin, dicloxacillin, and flucoxacillin (8) and also analyzed the influence of the molecular structure on the ideality of mixing in micelles formed in binary mixtures of these amphiphiles (9). 1 To whom correspondence should be addressed. E-mail: fsarmi@usc.es.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics of Association of Structurally Related Amphiphilic Penicillins

Taboada

Attwood

García

et al. 2000

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

“…The formation of micelles of penicillin G in aqueous solution was first observed by Hauser et al (12). Later studies (13,14) found the CMC to be relatively high, i.e., 0.25 molal, 130,000 units/ ml, or 8.26% (w/v). This value was further confirmed using the data of the NMR (100 MHz) chemical shift of the aromatic protons (15).…”

Section: Introductionmentioning

confidence: 98%