2011
DOI: 10.1016/j.anai.2010.05.010
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Penicillin skin testing in the evaluation and management of penicillin allergy

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Cited by 67 publications
(62 citation statements)
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“…We have confirmed a high negative predictive value (93.4%) for the ID skin test. Caubet et al [26] reported 91.5% specificity and 66.7% sensitivity for ID skin tests, and Fox and Park [27] also reported a negative predictive value > 95%. DPT is the gold standard to confirm allergy or tolerance to β-lactam antibiotics but this procedure is time consuming and the patient needs to be closely monitored for symptoms in a hospital setting with expert staff [13].…”
Section: Discussionmentioning
confidence: 99%
“…We have confirmed a high negative predictive value (93.4%) for the ID skin test. Caubet et al [26] reported 91.5% specificity and 66.7% sensitivity for ID skin tests, and Fox and Park [27] also reported a negative predictive value > 95%. DPT is the gold standard to confirm allergy or tolerance to β-lactam antibiotics but this procedure is time consuming and the patient needs to be closely monitored for symptoms in a hospital setting with expert staff [13].…”
Section: Discussionmentioning
confidence: 99%
“…These phenotypes and endotypes can be further assessed through biomarkers such as skin testing (ST), and specific IgE and basophil activation tests (BAT), which help identify mast cell involvement in the HSRs as well as cross reactivity between drugs [7,9,10,11,25,26,27,28,29]. Levels of basophil/mast cell activation mediators during HSRs, such as tryptase and histamine, or cytokine and leukotriene production, may be helpful in identifying cells involved in the HSR.…”
Section: Drug Hypersensitivity Reactions: New Clinical Approach Thmentioning
confidence: 99%
“…MGH and BWH additionally tested with penicillin G by both epicutaneous and intradermal skin testing. 46 At MGH, the mixing and diluting of penicillin G was performed by the consulting allergist, while BWH used the central pharmacy to compound and deliver the penicillin to the patient’s care unit via pneumatic tube or floor delivery. While the latter method ensured mixing was performed in a standardized fashion, it also caused operational delays since the timing of skin testing was reliant on the inpatient pharmacy workflow.…”
Section: Introductionmentioning
confidence: 99%