Penile deafferentation and the effect of mating experience on sexual motivation in adult male rats

Lodder, J.

doi:10.1016/0031-9384(76)90153-0

Cited by 27 publications

(11 citation statements)

References 13 publications

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“…Progressive removal of the dorsal pe nile nerve of male rhesus monkeys has been shown to dis rupt mounting, which ultimately ceases due to the reinforc ing effect of repeated non-stimulating copulation [17]. Rats with penile or pudendal denervation continue to mount al though intromissions are infrequent and ejaculation de layed or absent [23,25]. These changes resemble some of those seen in hyperprolactinaemic rats.…”

Section: Discussionmentioning

confidence: 52%

Impaired Copulatory Behaviour of Male Rats with Hyperprolactinaemia Induced by Domperidone or Pituitary Grafts

Bailey¹,

Herbert²

1982

Neuroendocrinology

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Sexually experienced male CFHB rats, castrated and implanted with testosterone, were chronically treated with domperidone (ca. 5 mg/kg/day). Twice-weekly tests of sexual behaviour showed a significant elevation of both mount latency and ejaculation latency, and suppression of mounting rate after 2–3 weeks of treatment. The number of mounts and intromissions before ejaculation was increased on some tests by domperidone. Experienced male WAG rats, also castrated and testosterone implanted, received three pituitary grafts under the kidney capsule. An increase in ejaculation latency was seen during the first week and then again several weeks after grafting, though implantation of non-endocrine tissue (muscle) into the controls may also have affected behaviour. Both treatments elevated serum prolactin levels, domperidone much more substantially than pituitary grafts. Serum testosterone levels were sustained within the normal intact range by the implants. The weights of the seminal vesicles, ventral prostate and adrenal glands were not significantly altered by either treatment. These experiments show that hyperprolactinaemia induced by two independent methods can retard sexual behaviour in male rats.

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Section: Discussionmentioning

confidence: 52%

Impaired Copulatory Behaviour of Male Rats with Hyperprolactinaemia Induced by Domperidone or Pituitary Grafts

Bailey¹,

Herbert²

1982

Neuroendocrinology

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“…Sexual experience has also been shown to ameliorate the disruptive effects of anosmia (Thor & Flannelly, 1977), castration (Lisk & Heiman, 1980;Fig. 2), penile deafferentation (Lodder, 1975), penile anesthesia with lidocaine ( Fig. 3), and age (Gray, Smith, Dorsa, & Davidson, 1981).…”

Section: Resistance To Disruptionmentioning

confidence: 96%

Who, What, Where, When (and Maybe Even Why)? How the Experience of Sexual Reward Connects Sexual Desire, Preference, and Performance

et al. 2012

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Although sexual behavior is controlled by hormonal and neurochemical actions in the brain, sexual experience induces a degree of plasticity that allows animals to form instrumental and Pavlovian associations that predict sexual outcomes, thereby directing the strength of sexual responding. This review describes how experience with sexual reward strengthens the development of sexual behavior and induces sexually-conditioned place and partner preferences in rats. In both male and female rats, early sexual experience with partners scented with a neutral or even noxious odor induces a preference for scented partners in subsequent choice tests. Those preferences can also be induced by injections of morphine or oxytocin paired with a male rat's first exposure to scented females, indicating that pharmacological activation of opioid or oxytocin receptors can "stand in" for the sexual reward-related neurochemical processes normally activated by sexual stimulation. Conversely, conditioned place or partner preferences can be blocked by the opioid receptor antagonist naloxone. A somatosensory cue (a rodent jacket) paired with sexual reward comes to elicit sexual arousal in male rats, such that paired rats with the jacket off show dramatic copulatory deficits. We propose that endogenous opioid activation forms the basis of sexual reward, which also sensitizes hypothalamic and mesolimbic dopamine systems in the presence of cues that predict sexual reward. Those systems act to focus attention on, and activate goal-directed behavior toward, reward-related stimuli. Thus, a critical period exists during an individual's early sexual experience that creates a "love map" or Gestalt of features, movements, feelings, and interpersonal interactions associated with sexual reward.

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“…A period of sexual rest, on the other hand, can modify male behavior (1 l), spermiogenesis ( 12), and primary sexual structures ( 13). Qualitative variation in sexual contact that is influenced by factors such as individual differences among females also can have a substantial impact on behavior and endocrinology of the male ( 14,15).…”

mentioning

confidence: 98%

Behavioral Endocrinology of Male Rats with Periodic Sexual Contacts with Exclusive or Varied Females

Taylor

Komitowski²,

Muto³

et al. 1989

Experimental Biology and Medicine

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Sexual contact keys a profound series of acute and chronic changes in males that, presumably, are orchestrated by acute pulsatile release of hormones. An experimental paradigm is reported in which male rats were paired periodically with either the same or different estrous females to receive identical amounts of copulatory experiences. Results confirmed the hypothesis that exposure to an unfamiliar female would induce a different endocrine response which would be reflected in various androgensensitive systems. The "successively polygynous" males showed more sexual behavior than l'monogamous" males, and their respective females solicited the males differently, as well. Circulating levels of testosterone were higher immediately after sexual contact with an unfamiliar than with a familiar female partner. There were no differences in testosterone titers among the groups when the animals were killed at either 2 or 7 weeks after the final copulatory experiences. Yet, necropsies at 2 weeks postcopulation revealed that primary and secondary sex structures from polygynous males clearly were larger. Differences between the two experimental groups were reduced after 7 weeks of sexual rest, yet, polygynous males continued to show a different structural profile than the other groups. Conclusions were that males may experience greater activation of androgen-sensitive behavior and physiology following qualitatively different sexual contacts. [ P S E B M 1989 Voll92] he behavior, physiology, and morphology of sexually experienced males differ dramatically from

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Penile deafferentation and the effect of mating experience on sexual motivation in adult male rats

Cited by 27 publications

References 13 publications

Impaired Copulatory Behaviour of Male Rats with Hyperprolactinaemia Induced by Domperidone or Pituitary Grafts

Impaired Copulatory Behaviour of Male Rats with Hyperprolactinaemia Induced by Domperidone or Pituitary Grafts

Who, What, Where, When (and Maybe Even Why)? How the Experience of Sexual Reward Connects Sexual Desire, Preference, and Performance

Behavioral Endocrinology of Male Rats with Periodic Sexual Contacts with Exclusive or Varied Females

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