Penile metastasis from recurrent sarcoma in a teenager: a case report

Abstract

Background Metastatic tumors of the penis are uncommon, and fewer than 500 cases have been reported since 1870. Most penile secondary tumors originate in organs of the genitourinary tract, followed by the gastrointestinal tract. Primary tumors of sarcoma origin are extremely rare. Herein, we present a teenager who had recurrent sarcoma of the right femur with penile metastasis. Case presentation The 20-year-old male patient was diagnosed with sarcoma of the right femur when he was 16 days old. He was stable following combination chemotherapy with the VAC regimen (vincristine, adriamycin, and cyclophosphamide) and debulking surgery. In January 2018, five months ago, he presented with right leg pain and swelling, and a recurrent tumor was found. Following excision of the tumor showed recurrent sarcoma. However, 2 months after the operation, right thigh swelling with tenderness occurred. A firm nodule on the glans of the penis was also noted. Penile metastasis was suspected and a biopsy was performed. The final pathology report disclosed pleomorphic sarcoma with penile metastasis. Symptoms including priapism and inguinal lymph node enlargement progressed rapidly within 2 weeks. He also complained of voiding difficulty with urine retention. The patient died 35 days after admission due to pneumonia with septic shock. Conclusion Penile metasitasis largely occurs from organs in the pelvis. To the best of our knowledge, this is the first case of a teenager with a secondary penile tumor, metastasizing from sarcoma of the bone. It presented as a palpable mass, and then progressed into priapism. The patient had a dismal prognosis and the symptoms progressed faster than his physicians anticipated.

Penile secondary lesions: a rare entity detected by PET/CT

“…Among our patients with focal uptake, PSL localized most commonly to the root in three fifths, to the shaft in almost one third, and to the glans in only one patient with DLBCL. PSL was previously demonstrated at the root and shaft at equivalent rates, and at the glans in one quarter of the cases 9,25,31 . Uptake along the shaft in our 2 patients with NSCLC strongly implied vascular spread.…”

“…However, we also detected PSL in patients with NSCLC, DLBCL, AML, and pelvic leiomyosarcoma. PSL have previously been recognized in lung cancer, lymphomas, AML, and pelvic leiomyosarcoma, though more than 90% originate in cancers of the genitourinary and gastrointestinal tracts [23][24][25][26] . Our 4 patients with lymphoma had DLBCL, corroborating reports that while found in both T-and B-cell lymphomas, PSL appear most commonly in DLBCL 27,28 .…”

Revisão sistemática sobre o câncer de pênis e sua relação com o HPV

“…A prevenção continuará sendo o foco no controle da doença até que um tratamento eficaz para a cura da infecção pelo HPV seja desenvolvido. Em mulheres, a vacinação é cada vez mais usada para prevenir a infecção pelo HPV e o subsequente desenvolvimento do câncer no colo do útero (CHEIN et al, 2019).…”