Penile preservation surgery in a case of erythroplasia of Queyrat involving the glans penis and distal urethra

Maruyama, Hiroshi; Fujisawa, Yasuhiro; Nakamura, Yasuhiro; Kawachi, Yasuhiro; Otsuka, Fujio

doi:10.1111/ijd.12103

Cited by 4 publications

(2 citation statements)

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“…A limited number of case reports have described penile BD with distal urethra involvement, and treatment options for these cases are limited. [5][6][7][8] Focal therapy, such as irradiation and laser for urethral lesions, may cause urethral stricture. 2,4 In addition, it is challenging to detect urethral lesions or their degree of involvement in the urethral mucosa using urethroscopy.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a partial penectomy was chosen for complete resection in many of the previous cases. [5][6][7] Conversely, a few reports have described that penile preservation surgery was performed for cases of BD involving the urethra, 8 and carbon dioxide laser vaporization was used for a case with visible urethral lesions. 9 In this case, a tumor lesion of BD was present 7 mm from the external orifice, suggesting that a glansectomy would likely be reasonable to preserve urinary function.…”

Section: Discussionmentioning

confidence: 99%

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Human papillomavirus 16–positive penile Bowen’s disease involving the distal urethra: A case report

Sakamoto

Shigehara

Shimizu

et al. 2020

SAGE Open Medical Case Reports

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A 79-year-old man visited our hospital with a chief complaint of erythema around the urethral orifice of the glans, and a diagnosis of penile Bowen’s disease was made by penile skin biopsy. Initially, local tumor resection with skin grafting from the femoral skin was performed. However, histopathological examination revealed a positive urethral margin of tumor. Since the degree of urethral lesion of penile Bowen’s disease was unclear, the patient received glansectomy. Histopathological examination revealed a tumor lesion in the distal urethra, 7 mm from the external urethral orifice, and confirmed the complete resection of urethral Bowen’s disease. The patient recovered well, with no definite recurrence of Bowen’s disease up to 13 months after partial penectomy. Human papillomavirus 16 DNA was detected in the paraffin-embedded tumor sample, and in situ hybridization confirmed human papillomavirus 16 DNA locations in the tumor tissue. Immunohistochemistry revealed that p16-INK4a was widely expressed in the tumor tissue.

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