Penile warty mucoepidermoid carcinoma with features of stratified mucin‐producing intra‐epithelial lesion and invasive stratified mucin‐producing carcinoma

Abstract

The lack of glands in the mucinous areas suggested that MEC should be separated from adenosquamous carcinoma (ASC). Penile SMILE/ISMC may occur without dependence upon HPV status. Further studies will be necessary to determine the pathogenesis and definition of penile SMILE/ISMC, the presence of true MEC arising from the glans penis and the clinicopathological differences of penile ASC, MEC and SMILE/ISMC. Herein, we refer to the SMILE-like penile lesion as 'mucinous penile intra-epithelial neoplasia'.

Invasive stratified mucin-producing carcinoma of the colorectum: Expanding the morphologic spectrum of large bowel cancer

“…The tumor was rst described in the cervix as a human papilloma virus (HPV)-associated neoplasm. Similar tumors have since been reported in other sites such as the penis and the anus, with or without an association with HPV [6][7][8][9][10]. An analogous phenomenon of epithelial strati cation has also been recently described in the non-cribriform variant of prostatic adenocarcinoma and in transition zone adenocarcinomas [11,12].…”

“…What is not as well-known is the phenomenon of epithelial strati cation with intracytoplasmic mucin. However, this observation has recently been described in the cervix, anus, penis and prostate [1][2][3][4][5][6][7][8][9]. The current study shows that this phenomenon can also occur in the colorectum.…”

“…With poorly differentiated conventional adenocarcinomas (NOS), the glands are still present though they are highly irregular and more di cult to discern compared to low-grade tumors. Furthermore, these tumors are often quite desmoplastic with irregular in ltrative margins/high tumorbudding scores [22,[25][26][27], and lack the trans-lesional strati ed pattern with peripheral palisading of ISMCs [1][2][3][4][5][6][7][8][9].…”

“…The slides were reviewed to determine whether there were any cases ful lling the diagnostic criteria of ISMC as stipulated in previous publications [1][2][3][4][5][6][7][8][9], namely: i) stromal invasive carcinoma composed of solid peripherally-palisaded nests of tumor cells containing variable amounts of intracytoplasmic mucin strati ed throughout the entire tumor thickness ii) the tumors were regarded as pure if ≥ 90% of the tumor was ISMC and iii) mixed if the ISMC component was ≥ 10% and < 90%. iv) Tumors with < 10% of the ISMC component were excluded from the study.…”