Penis Transplantation

Cetrulo, Curtis L.; Li, Kai; Salinas, Harry M.; Treiser, Matthew D.; Schol, Ilse; Barrisford, Glen W.; McGovern, Francis J.; Feldman, Adam S.; Grant, Michael; Tanrikut, Cigdem; Lee, Jeffrey H.; Ehrlichman, Richard J.; Holzer, Paul; Choy, Garry; Liu, Raymond W.; Ng, Zhi Yang; Lellouch, Alexandre G.; Kurtz, Josef; Austen, William G.; Winograd, Jonathan M.; Bojovic, Branko; Eberlin, Kyle R.; Rosales, Ivy A.; Colvin, Robert B.; Ko, Dicken

doi:10.1097/sla.0000000000002241

Cited by 82 publications

(32 citation statements)

References 25 publications

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“…Reports at 24 months include successful erections from week 3, sexual intercourse from week 5 (against medical advice) and pregnancy at 3 months, unfortunately leading to a stillbirth. Early reports from the first USA case are also encouraging with partial sensory recovery at 7 months, spontaneous erection and improved psychological parameters [65].…”

Section: Penis Transplantmentioning

confidence: 89%

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Vascularised Composite Allotransplantation – Basic Science and Clinical Applications

Honeyman

Fries

2019

International Journal of Orthoplastic Surgery

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Vascularised Composite Allotransplantation (VCA) is the top rung of the reconstructive ladder, offering 'like-for like' functional reconstruction for the most devastating tissue loss. There are established centres across Europe, the USA and Asia. Clinical outcomes now extend beyond 20 years. To-date over 130 upper limb and 37 craniofacial VCA's have been performed, with encouraging graft survival and clinical outcomes. Beyond hand and face transplantation novel VCA's have been performed including: functioning allotransplantation of neck organs, penis, uterus and skull and scalp transplants. Like solid organ transplant (SOT) patients, VCA recipients are submitted to the significant side effects of lifelong immunosuppression, however in this case surgery is considered life improving rather than life saving. As clinical feasibility is now well established research focus has shifted to improve the safety profile of VCA. This has included exploring strategies to enable early detection and treatment of acute rejection, defining and better understanding chronic rejection in VCA, and ultimately aiming to induce tolerance. The aim of this review article is to give a concise overview of the clinical and basic science advances in the field of VCA, with particular relevance to the orthoplastic surgeon.

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Section: Penis Transplantmentioning

confidence: 89%

“…To-date there have been 4 successful penis/penis scrotum transplants performed worldwide, in three centres in the United States and South Africa [10,[65][66][67]. The first case of penile transplant was performed in China in 2006, but was removed 14 days later due to significant psychological distress experienced by the recipient [68].…”

Section: Penis Transplantmentioning

confidence: 99%

Vascularised Composite Allotransplantation – Basic Science and Clinical Applications

Honeyman

Fries

2019

International Journal of Orthoplastic Surgery

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“…The much anticipated details of the first male genital transplant performed in the United States with surgical specifics and the patient’s post-operative course were published earlier this year ( 15 ). A high resolution computed tomography angiogram, diagnostic angiography and magnetic resonance imaging were performed pre-operatively.…”

Section: Review Of Penile Transplantation In the Usmentioning

confidence: 99%

Penile transplantation: the US experience and institutional program set-up

Szafran¹,

Redett²,

Burnett³

2018

Transl. Androl. Urol.

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Penile transplantation using vascularized composite allografts is an emerging technique to treat genital loss. In the United States, this procedure has been performed successfully at Massachusetts General Hospital in a patient who had previously undergone treatment for penile cancer. The Johns Hopkins Medical Institutions has developed a research protocol to perform penile transplantation in patients with genital loss secondary to trauma. The process of selecting the appropriate candidate for genitourinary (GU) vascularized composite allograft surgery is rigorous including extensive physical examination, laboratory testing, imaging and psychological evaluations. After transplantation, limiting the potential complications associated with immunosuppression is critical given that the procedure is intended to improve quality of life and is not life-saving. Ultimately, penile transplant is a surgical intervention which may have numerous applications. Optimization of the pre-operative screening process, surgical technique, and immunosuppressive protocol is required to establish this method as the standard treatment for patients with genital loss and limited reconstructive options.

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“…Uterine factor infertility affects approximately 1 in 500 women worldwide [20]. however, these episodes were reversed with IV corticosteroids and the children were born healthy [24].…”

Section: Uterine Transplantationmentioning

confidence: 99%

“…The procedure began with allograft procurement concurrent with recipient preparation, including the dissection of the right groin and penile stump. After all critical nerves and vessels paralleling the allograft were exposed, revascularization began with anastomoses of the urethra, corpora, cavernosal and dorsal arteries[20]. Flow to these vessels and skin was established using a Open Journal of Organ Transplant Surgeryvein graft that did not require multiple arterial anastomoses, which was previously expected due to the estimation of the robust collateral circulation of the penis.…”

mentioning

confidence: 99%

New Frontiers in Transplantation and Stem Cell Technology: A Brief Synopsis

Javadi¹,

Brooks²,

Obi-Umahi³

et al. 2018

OJOTS

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Since the first kidney transplant was performed in 1954 immense progress has been made in the world of transplantation. Modern immunosuppressive regimens have led to increasing graft and patient survival after solid organ transplantation. Furthermore, these advances have opened the door to new fields of transplantation such as composite tissue allotransplantation. These developments have made possible numerous types of transplantation including, but not limited to face, penile, and uterine transplantation. Moreover, innovations in genetic engineering and stem cell technology have contributed to rapid developments in the fields of xenotransplantation and the engineering of functional organs from induced pluripotent stem cells. As the prevalence of chronic diseases rises, so too will the necessity for organ transplantation. Thus, the transplant innovations of the modern era need to be expanded upon so as to continue to discover new ways to address organ shortages and the complications of transplantation.

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Penis Transplantation

Cited by 82 publications

References 25 publications

Vascularised Composite Allotransplantation – Basic Science and Clinical Applications

Vascularised Composite Allotransplantation – Basic Science and Clinical Applications

Penile transplantation: the US experience and institutional program set-up

New Frontiers in Transplantation and Stem Cell Technology: A Brief Synopsis

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