Peniscopically Controlled CO2 Laser Excision for Conservative Treatment of In Situ and T1 Penile Carcinoma: Report on 224 Patients

Penile cancer is an aggressive disease, with major psychological and social impact. The etiological factors are poor genital hygiene, the presence of phimosis, viral infection, ultraviolet radiation, smoking, balanitis xerotic obliterans, and chronic lichen. Identifying prognostic factors is important to select patients at risk for lymph node metastasis and avoid unneeded lymphadenectomy. The presence of lymph node metastasis is currently the strongest prognostic factor but its evaluation is imperfect using clinical and laboratorial methods. The treatment for invasive penile cancer is based on the treatment of primary tumor, usually with amputation and regional lymphadenectomy, treatments that have a high morbidity rate.

show abstract

“…The 10-year salvage amputation rate was 5.5%, and there was no significant difference between TIS and T1 outcomes [46].…”

Section: Treatment Of the Primary Lesionmentioning

confidence: 83%

“…Bandieramonte et al [46] demonstrated effective cancer control and 10-year recurrence-free survival of greater than 80% using CO2 laser therapy in patients with either in situ or T1 cancers. The 10-year salvage amputation rate was 5.5%, and there was no significant difference between TIS and T1 outcomes [46].…”

Section: Treatment Of the Primary Lesionmentioning

confidence: 98%

Penile Cancer: Epidemiology and Treatment

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Some no longer apply this technology to T2 tumors as there may be a higher risk for nodal metastasis (35). Neoadjuvant reductive chemotherapy using vincristine, bleomycin and methotrexate with peniscopy in concert with CO2 laser has been reported with favorable results (36).…”

Section: Surgery Of the Primary Tumormentioning

confidence: 99%

Update in the management of penile cancer

et al. 2009

View full text Add to dashboard Cite

Purpose: The management of penile cancer has evolved as less invasive techniques are applied in the treatment of the primary tumor and inguinal lymph nodes. Materials and Methods: Herein we review the literature focusing on advances in the preservation of the phallus as well as less morbid procedures to evaluate and treat the groins. Results: Promising imaging modalities for staging are discussed. New techniques are described and tables provided for penile preservation. We also review the contemporary morbidity of modified surgical forms for evaluation of the inguinal nodes. Conclusions: Advances in surgical technique have made phallic preservation possible in a greater number of primary penile cancers. The groins can be evaluated for metastasis with greater accuracy through new radiologic means as well as with less morbid modified surgical techniques.

show abstract

“…Surgical options include partial penectomy or glansectomy. 50 For smaller lesions, neoadjuvant chemotherapy (including vinblastine, bleomycin, and methotrexate) followed by CO2 laser excision 51 has been reported, but is not commonly used in Canada. Radiotherapy for lesions under 4 cm can be used.…”

Section: Stage T1mentioning

confidence: 99%