Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas

Collingridge, David R.; Rockwell, Sara

doi:10.1002/1097-0215(20001020)90:5<256::aid-ijc2>3.3.co;2-i

Cited by 5 publications

(10 citation statements)

References 21 publications

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“…The BA1112 tumor has been used extensively in radiation biology and experimental cancer therapy studies in our laboratory and elsewhere. 35–38 The BMB subline arose as a spontaneous variant of the BA1112, and was first noted during a tumor therapy experiment, when rats bearing the normally non-metastatic BA1112 tumors began developing large numbers of lung metastases while being followed for long-term tumor control (cure). The growth rate and histology of this metastatic subline resemble those described previously for the parental tumor line; 35,38 however, the incidence of lung metastases is greatly elevated.…”

Section: Methodsmentioning

confidence: 99%

Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs

Rockwell¹,

Liu²,

Mayne³

et al. 2011

Exp Biol Med (Maywood)

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Cancer patients often have subclinical vitamin A deficiencies and low vitamin A lung levels. Previous studies showed that subclinical vitamin A deficiency increased the severity of pneumonitis induced by whole-lung irradiation in rats. Many studies have shown that lung irradiation increases the number of lung tumors developing from intravenously injected tumor cells in mice. We examined the impact of vitamin A deficiency on the development of lung metastases from a highly metastatic syngeneic rat rhabdomyosarcoma in normal rats and rats receiving prior lung irradiation. Weanling female WAGrijY rats were randomized to receive either a diet lacking both vitamin A and beta-carotene or a control diet. After five weeks, the deficient diet significantly decreased levels of retinol in the lung and liver but not in the serum, modeling the tissue and blood levels seen in prior studies of patients with subclinical vitamin A inadequacy. The vitamin A-deficient diet did not alter the number of lung tumors developing from intravenously injected tumor cells in unirradiated rats. Whole-lung irradiation produced dose-dependent increases in the number of lung tumors developing from tumor cells injected intravenously one or 29 d after irradiation. Vitamin A deficiency did not alter these dose–response curves, indicating that the more intense radiation-induced pneumonitis seen previously in vitamin A-deficient rats did not alter the enhancement of metastases produced by whole-lung irradiation. Moreover, inadequate vitamin A intake did not influence the growth of tumors implanted subcutaneously or increase the number or size of the spontaneous lung metastases developing from these subcutaneous tumors. Thus, although low vitamin A status influences the development of lung injury and is considered a possible modifiable risk factor increasing risk of primary cancer, it did not affect the growth of subcutaneous tumors or increase the development of artificial or spontaneous lung metastases in this rat model.

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Section: Methodsmentioning

confidence: 99%

Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs

Rockwell¹,

Liu²,

Mayne³

et al. 2011

Exp Biol Med (Maywood)

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“…Investigators believe that MWCNTs-collagen scaffolds signifi cantly enhanced the differentiation of MSCs at 10 ppm. In another study, investigators showed that all types of MWCNT-collagen scaffolds induced the higher level of MSC differentiation compared to controls [60]. However, MWCNTs-collagen scaffolds were less likely to affect MSCs proliferation with no signifi cant difference in MSC morphology before and after differentiation.…”

Section: Characterization and Toxicity Of Swcnt And Mwcnt Carbon Nano...mentioning

confidence: 96%

“…The MRI microimaging was performed before and after placing nm CNT in glass capillaries at different intervals of 2, 4, 6 hours using scan parameters: TR/TE/fl ip angle = 750ms/ 4.18ms/25°, FOV/matrix size/spatial resolution = 2.6×3.4 cm/ 256×256/0.015 mm, and the inversion time (TI approximately 250 ms) set to null normal skin. Epidermis and hair follicle were measured as reported by Sharma et al (2010) [60].…”

Section: Characterization and Toxicity Of Swcnt And Mwcnt Carbon Nano...mentioning

confidence: 99%

Carbon Nanotubes: Nanotoxicity Testing and Bioapplications

Sharma¹,

Kwon²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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With the growing use of nanomaterials in bioapplications, the nanotoxicity of new nanomaterials has become a safety concern when used in various applications. In this chapter, technical developments on carbon nanotubes are described including a historical account, experimental models and potential bioapplications.Carbon nanotube (CNT) materials display superior properties in electric current carrying capacity, thermal conductivity, and thermal stability. Due to the unique CNT structure with high-aspect ratio, CNT may show unusual toxicity and complicate its safe use in a target tissue. To test nanotoxicity of CNT, we describe a set of protocols of prior knowledgebased physical and chemical characteristics to develop 3-dimensional in vitro models of the intact skin, and a 3D in vitro model of the human airway using a co-culture of normal human bronchial epithelial cells and normal human fibroblasts. The human airway 3D model served as a tool of health risk assessment of CNTs on the human respiratory systems. To test functionality at different CNT concentrations in a 3D model, physical characteristics of multiwalled CNTs and production of nitric oxide (NO) served as cell viability and inflammatory marker; mitochondrial activity (MTT assay) served as the cytotoxic response of the epithelial cell layers; transepithelial electrical resistance (TER) measured nanotoxicity in the changes in airway physiological function. Cytoxicity and inflammatory responses of CNTs were dependent on different size, mass, shape, and functionality of CNTs as viable in vivo tests were conducted to evaluate the Ashutosh Tiwari and Atul Tiwari (eds.) Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering,

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“…90 A number of other agents evaluated preclinically, including pentoxifylline and nicotinamide, also improved tumor blood flow and response to radiotherapy. [91][92][93] However, clinical trials of nicotinamide have encountered considerable toxicities, with some patients experiencing nausea and vomiting that was unresponsive to antiemetics. 91 high oxygen content breathing Hyperbaric chambers Oxygen delivery to tissues is dependent on several factors, mainly blood flow, oxygen content, and oxygen tension.…”

Section: Overcoming Anemiamentioning

confidence: 99%

Tumor oxygenation and cancer therapy—then and now

Hughes

Wiggins

Siemann

2018

BJR

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In 2012, cancer affected 14.1 million people worldwide and was responsible for 8.2 million deaths. The disease predominantly affects aged populations and is one of the leading causes of death in most western countries. In tumors, the aggressive growth of the neoplastic cell population and associated overexpression of pro-angiogenic factors lead to the development of disorganized blood vessel networks that are structurally and functionally different from normal vasculature. A disorganized labyrinth of vessels that are immature, tortuous and hyperpermeable typifies tumor vasculature. Functionally, the ability of the tumor vasculature to deliver nutrients and remove waste products is severely diminished. A critical consequence of the inadequate vascular networks in solid tumors is the development of regions of hypoxia [low oxygen tensions typically defined as oxygen tensions (pO values) < 10 mm Hg]. Tumor cells existing in such hypoxic environments have long been known to be resistant to anticancer therapy, display an aggressive phenotype, and promote tumor progression and dissemination. This review discusses the physiological basis of hypoxia, methods of detection, and strategies to overcome the resulting therapy resistance.

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Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas

Cited by 5 publications

References 21 publications

Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs

Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs

Carbon Nanotubes: Nanotoxicity Testing and Bioapplications

Tumor oxygenation and cancer therapy—then and now

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