Pentraxin 3 and D‐dimer in children with asthma: A real‐world study

Licari, Amelia; Amici, Mara De; Ciprandi, Giorgio

doi:10.1111/cea.13364

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…Still, no correlation was found with lung functions, asthma control grade, asthma severity, eosinophil count, or D-dimer level. 25 Similarly, our study found that CSU patients had increased CRP, D-dimer, and lymphocyte levels. Still, except for CRP, there was no correlation between PTX3 and other laboratory markers, disease severity, urticaria activity score, or other disease parameters.…”

Section: Resultssupporting

confidence: 68%

Circulating Pentraxin-3 and its association with C-reactive protein levels and disease activity in patients with chronic spontaneous urticaria

Beyaz¹,

Belkaya

Öztop

2023

Allergol Immunopathol

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Introduction: Pentraxin-3 (PTX3) is a soluble long pentraxin molecule that regulates inflammatory responses. This study aimed to determine the plasma levels of plasma PTX-3 as an inflammation marker in chronic spontaneous urticaria (CSU) and whether the PTX3 levels correlate with disease activity and other clinical parameters, including acute phase reactants and biomarkers. Methods: The study included 70 CSU patients and 30 healthy controls. Plasma PTX3 levels were measured by ELISA. CSU disease activity was evaluated with the urticaria activity score summed over 7 days. Complete blood count, C-reactive protein (CRP), transaminases, total IgE, antinuclear antibody, anti-thyroid peroxidase, anti-thyroglobulin, and D-dimer levels were recorded. Results: Of the 70 patients, 52 (74.3%) were female, with a mean age of 37.51 ± 11.80 years. Disease activity was severe in 43, moderate in 15, and mild in 12 patients. Mean PTX3 levels were elevated in CSU patients compared to healthy controls (0.81 vs. 0.55 ng/mL, p = 0.031). The mean CRP levels were higher in patients than in the controls (4.26 vs. 1.57 mg/L, p = 0.023). Patients also had higher D-dimer levels than the controls (5.96 vs. 0.59 mg/L, p < 0.001). A significant positive correlation was found between PTX3 and CRP levels (r = 0.508, p < 0.001) and between D-dimer levels and UAS7 (r = 0.338, p = 0.004) and CRP (r = 0.213, p = 0.034) levels. A multivariable stepwise regression analysis showed that the one-unit increase in the CRP level increased to 38.19 units in the PTX3 level (95% confidence interval [17.40–58.98], p < 0.001). Conclusion: Circulating levels of CRP and PTX3, two members of the pentraxin family, are significantly correlated and elevated in CSU patients with increasing disease activity, indicating their utility as inflammatory markers in CSU.

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Section: Resultssupporting

confidence: 68%

Circulating Pentraxin-3 and its association with C-reactive protein levels and disease activity in patients with chronic spontaneous urticaria

Beyaz¹,

Belkaya

Öztop

2023

Allergol Immunopathol

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“…Similarly, significant positive correlations were identified between PTX3 sputum concentrations and eosinophil counts in sputum and blood as well as total serum immunoglobulin E (IgE) levels [22]. These findings have been confirmed recently in an independent study in a group of over 100 children with allergic asthma [71]. Notably, there is also a role for PTX3 in children with allergic rhinitis [37].…”

Section: Pentraxinsmentioning

confidence: 99%

“…Mechanistically, the Th17‐dominant allergic response in these mice was supported by the Th17‐polarizing cytokines IL‐6 and IL‐23 from DCs [21]. In summary, serum PTX3 levels might be a valuable marker to demonstrate the presence of low‐grade inflammation in asthma [71]. However, serum PTX3 levels seem to be inadequate as marker for asthma management, and it remains a matter of debate whether PTX3 might be directly involved in the etiology of allergic airway inflammation.…”

Section: Pentraxinsmentioning

confidence: 99%

Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces

2020

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Maintenance of homeostasis at body barriers that are constantly challenged by microbes, toxins and potentially bioactive (macro)molecules requires complex, highly orchestrated mechanisms of protection. Recent discoveries in respiratory research have shed light on the unprecedented role of airway epithelial cells (AEC), which, besides immune cells homing to the lung, also significantly contribute to host defence by expressing membranebound and soluble pattern recognition receptors (sPRR). Recent evidence suggests that distinct, evolutionary ancient, sPRR secreted by AEC might become activated by usually innocuous proteins, commonly referred to as allergens. We here provide a systematic overview on sPRR detectable in the mucus lining of AEC. Some of them become actively produced and secreted by AECs (like the pentraxins C-reactive protein and pentraxin 3; the collectins mannose binding protein and surfactant proteins A and D; H-ficolin; serum amyloid A; and the complement components C3 and C5). Others are elaborated by innate and adaptive immune cells such as monocytes/macrophages and T cells (like the pentraxins C-reactive protein and pentraxin 3; L-ficolin; serum amyloid A; and the complement components C3 and C5). Herein we discuss how sPRRs may contribute to homeostasis but sometimes also to overt disease (e.g. airway hyperreactivity and asthma) at the alveolar-air interface.

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“…In another study, sputum pentraxin-3 concentration was significantly higher in children with asthma than in control subjects and correlated with atopic status and disease severity among patients with asthma ( 109 ). Also, Licari et al showed that pentraxin-3 is a valuable marker for the presence of a low-grade inflammatory status and a low-grade fibrinolytic activity in children with asthma but could not detect significant associations with asthma severity and asthma control ( 110 ).…”

Section: Pentraxin-3 In Asthmamentioning

confidence: 99%

New Insights on the Role of pentraxin-3 in Allergic Asthma

et al. 2021

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Pentraxins are soluble pattern recognition receptors that play a major role in regulating innate immune responses. Through their interaction with complement components, Fcγ receptors, and different microbial moieties, Pentraxins cause an amplification of the inflammatory response. Pentraxin-3 is of particular interest since it was identified as a biomarker for several immune-pathological diseases. In allergic asthma, pentraxin-3 is produced by immune and structural cells and is up-regulated by pro-asthmatic cytokines such as TNFα and IL-1β. Strikingly, some recent experimental evidence demonstrated a protective role of pentraxin-3 in chronic airway inflammatory diseases such as allergic asthma. Indeed, reduced pentraxin-3 levels have been associated with neutrophilic inflammation, Th17 immune response, insensitivity to standard therapeutics and a severe form of the disease. In this review, we will summarize the current knowledge of the role of pentraxin-3 in innate immune response and discuss the protective role of pentraxin-3 in allergic asthma.

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Pentraxin 3 and D‐dimer in children with asthma: A real‐world study

Cited by 5 publications

References 9 publications

Circulating Pentraxin-3 and its association with C-reactive protein levels and disease activity in patients with chronic spontaneous urticaria

Circulating Pentraxin-3 and its association with C-reactive protein levels and disease activity in patients with chronic spontaneous urticaria

Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces

New Insights on the Role of pentraxin-3 in Allergic Asthma

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