PEO–PPO–PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers

Cohn, Daniel; Lando, Gilad; Sosnik, Alejandro; Garty, Shai; Levi, Avraham

doi:10.1016/j.biomaterials.2005.10.035

Cited by 138 publications

(89 citation statements)

References 15 publications

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“…The group developed the idea of thermoresponsive PEO/PPO polymers with improved mechanical behavior further in the next years. Their strategies included i) introduction of end groups that would allow for in situ chemical crosslinking after thermal gelation, such as carbon-carbon double bonds [63], ethoxysilane groups [62,64] and methacrylate groups [64] ii) synthesis of poly(ethylene oxide) and poly(propylene oxide) block copolymers using diacyl chloride as a coupling agent [65] iii) synthesis of PEO/PPO copolymers with incorporation of ε-caprolactone [65,66] or lactide [66] oligoester segments prior to chain extension. The latter approach yielded biodegradable hydrogels due to hydrolytic cleavage of the ester bonds.…”

Section: Peo/ppo-based Systemsmentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,132

696

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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.

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Section: Peo/ppo-based Systemsmentioning

confidence: 99%

Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,132

696

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“…Este tipo de polí-mero puede vehicular y liberar lentamente la hormona fsh en la sangre, permite su acción sobre los folículos reclutados, evita la formación de un folículo dominante y presenta crecimiento y ovulaciones múltiples [62].…”

Section: Polímeros Transportadores De Hormonas Reproductivasunclassified

“…El pf 127 tiene una duración media dependiente de las cadenas que él forma con otros polímeros, como el alcohol polivinílico (pva), lo cual puede mejorar la estabilidad y la duración dentro del cuerpo [62].…”

Section: Polímeros Transportadores De Hormonas Reproductivasunclassified

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Superovulación de hembras bovinas

Waltero

Dias

2013

Spei Domus

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Las mejorías en la eficiencia reproductiva y la multiplicación de genotipos más productivos están directamente ligadas a incrementos en la productividad, los cuales son factores decisivos para la sustentabilidad de la actividad pecuaria. Por esta razón, las investigaciones en este campo proponen la transferencia de embriones (te) como una de las herramientas biotecnológicas básicas para aumentar la cantidad y la calidad de los bovinos producidos. El proceso convencional de superovulación para teen bovinos utiliza ocho aplicaciones de hormona folículo estimulante (fsh) con intervalos de 12 horas; este procedimiento aumenta la manipulación y el estrés de los animales, lo que hace que incida negativamente en los resultados. El objetivo de esta revisión es compilar los progresos más marcados de las dos últimas décadas en las investigaciones que han centrado su interés en la reducción del número de aplicaciones de fsh,habiendo utilizado para ello estrategias que van desde la simple aplicación subcutánea de la hormona hasta su transporte y liberación controlada en dispositivos electrónicos colocados en el tracto reproductivo, pasando también por la vehiculización en sustancias poliméricas que permiten controlar la liberación hacia el torrente sanguíneo. Concluimos que indudablemente estos avances revolucionarán la industria pecuaria e influirán de manera positiva en la masificación del uso de biotecnologías embrionarias, lo cual permitirá, por obvias razones, mejorías genéticas evidentes en lapsos de tiempo más cortos dentro de los hatos bovinos.

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“…As pointed in previous studies and unlike the other mass detection techniques (such as SPR), QCM measures the wet mass on the crystals surface, i.e., copolymer mass coupled with water [54,55]. The interaction between the hydrophilic PEO blocks of copolymers and water at both the solid-liquid interface and bulk solution is temperature-dependant, i.e., temperature driven dehydration of PEO blocks at high temperature [56,57]. At 65 • C (above cloud point), PEO blocks dehydrate and therefore shrink, resulting in lighter adsorbed layer on interface, shown in Figure 4a,b.…”

Section: Surface Film Adsorptionmentioning

confidence: 99%

Surface Film Adsorption and Lubricity of Soybean Oil In-Water Emulsion and Triblock Copolymer Aqueous Solution: A Comparative Study

2016

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This paper investigates the surface film adsorption and lubricity of two different types of potential environmentally friendly cold metal forming lubricants: soybean vegetable oil in water VO/W emulsions and triblock copolymer aqueous solutions. The lubricants have different visual appearance, surface film adsorption characteristic, lubricity and surface cleaning behaviour. The effects of concentration, temperature and emulsification ultrasonic energy (for VO/W emulsion) are studied. The result shows that the soybean VO/W emulsions have stronger adsorption, superior lubricity and anti-wear property compared to the copolymer solutions. The effect of temperature is investigated at 30 • C and 65 • C which are below and above cloud point of the aqueous copolymer solutions. Both lubricants show improved friction and anti-wear property at 65 • C. However, tenacious residual film remained on the discs surface after surface cleaning indicates lower cleanability of the soybean VO/W emulsions compared to the copolymer solutions, postulating the need for extra post-processing cleaning operations after cold forming process with VO/W emulsion lubricant.

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PEO–PPO–PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers

Cited by 138 publications

References 15 publications

Thermoresponsive hydrogels in biomedical applications

Thermoresponsive hydrogels in biomedical applications

Superovulación de hembras bovinas

Surface Film Adsorption and Lubricity of Soybean Oil In-Water Emulsion and Triblock Copolymer Aqueous Solution: A Comparative Study

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