Peptaivirins A and B, two new antiviral peptaibols against TMV infection

Yun, Bong Sik; Yoo, Ick Dong; Kim, Young Ho; Kim, Young Sook; Lee, Sang Jun; Kim, Kab Sig; Yeo, Woon Hyung

doi:10.1016/s0040-4039(99)02308-4

Cited by 54 publications

(25 citation statements)

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“…Peptaibols have been shown to generally exhibit antimicrobial activity against Gram‐positive bacteria and fungi (Jen et al , 1987). Only two peptaibols, Peptaivirins A and B from Sepedonium spp., were reported to have inhibitory activity against TMV infection to tobacco (Yun et al , 2000; Yeo et al , 2002). Trichokonins, a group of peptaibols produced by Trichoderma pseudokoningii SMF2, were demonstrated to exhibit antimicrobial activity against a range of Gram‐positive bacterial and fungal phytopathogens in vitro (Song et al , 2006).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus

Luo

Zhang

Dong

et al. 2010

FEMS Microbiology Letters

128

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Trichoderma spp. are well-known biocontrol agents because of their antimicrobial activity against bacterial and fungal phytopathogens. However, the biochemical mechanism of their antiviral activity remains largely unknown. In this study, we found that Trichokonins, antimicrobial peptaibols isolated from Trichoderma pseudokoningii SMF2, could induce defense responses and systemic resistance in tobacco (Nicotiana tabacum var. Samsun NN) against tobacco mosaic virus (TMV) infection. Local Trichokonin (100 nM) treatment led to 54% lesion inhibition, 57% reduction in average lesion diameter and 30% reduction in average lesion area in systemic tissue of tobacco compared with control, indicating that Trichokonins induced resistance in tobacco against TMV infection. Trichokonin treatment increased the production of reactive oxygen species and phenolic compounds in tobacco. Additionally, application of Trichokonins significantly increased activities of pathogenesis-related enzymes PAL and POD, and upregulated the expression of several plant defense genes. These results suggested that multiple defense pathways in tobacco were involved in Trichokonin-mediated TMV resistance. We report on the antivirus mechanism of peptaibols, which sheds light on the potential of peptaibols in plant viral disease control.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus

Luo

Zhang

Dong

et al. 2010

FEMS Microbiology Letters

128

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“…They show interesting physico-chemical and biological activities depending on particular structural properties, such as the formation of pores in bilayer lipid membranes as well as antibacterial, antifungal, occasionally antiviral [1] and antiparasitic activities [2]. Inhibition of mitochondrial ATPase, uncoupling of oxidative phosphorylation, immunosuppression [3][4][5][6][7], inhibition of platelet aggregation [8], induction of fungal morphogenesis and neuroleptic effects [9][10][11][12] have been reported.…”

Section: Introductionmentioning

confidence: 99%

The occurrence of peptaibols and structurally related peptaibiotics in fungi and their mass spectrometric identification via diagnostic fragment ions

Degenkolb

Berg

Gams

et al. 2003

Journal of Peptide Science

123

100

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Peptaibols and related peptide antibiotics (peptaibiotics) display diagnostically useful fragmentation patterns during mass spectrometry (FAB-MS, ESI-CID-MS/MS and CID-MS n ). The paper compiles fragmentation data of pseudo-molecular ions reported in the literature as a guide to the rational identification of recurrently isolated and new peptaibols and peptaibiotics. Taxonomic and ecological aspects of microorganisms producing peptaibols and peptaibiotics are discussed.

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“…The role of peptaibols in sporulation and mycoparasitism has been hypothesized (24), and their involvement in induced disease resistance in plants has been demonstrated (18,(25)(26)(27). Recently, a microheterogenous mixture of 20-residue peptaibols isolated from an endophytic biocontrol strain of Trichoderma citrinoviride has been demonstrated to have antifungal activities against several important forest tree pathogens, thus implicating their role in biocontrol (28).…”

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confidence: 99%

Two Classes of New Peptaibols Are Synthesized by a Single Non-ribosomal Peptide Synthetase of Trichoderma virens

Mukherjee

Wiest

Ruiz

et al. 2011

Journal of Biological Chemistry

107

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Peptaibols are a group of small peptides having a high ␣-aminoisobutyric acid (Aib) content and produced by filamentous fungi, especially by the members of the genus Trichoderma (anamorph Hypocrea). These antibiotics are economically important for their anti-microbial and anti-cancer properties as well as ability to induce systemic resistance in plants against microbial invasion. In this study we present sequences of two classes (11-residue and 14-residue) of peptaibols produced by the biocontrol fungus Trichoderma virens. Of the 35 11-residue peptaibols sequenced, 18 are hitherto not described, and all the 53 14-residue sequences described by us here are new. We have also identified a peptaibol synthetase (non-ribosomal peptide synthetase, NRPS) with 14 complete modules in the genome of this fungus and disruption of this single gene (designated as tex2) resulted in the loss of both the classes of peptaibols. We, thus present here an unprecedented case where a single NRPS encodes for two classes of peptaibols. The new peptaibols identified here could have applications as therapeutic agents for the management of human and plant health.

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Peptaivirins A and B, two new antiviral peptaibols against TMV infection

Cited by 54 publications

References 1 publication

Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus

Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus

The occurrence of peptaibols and structurally related peptaibiotics in fungi and their mass spectrometric identification via diagnostic fragment ions

Two Classes of New Peptaibols Are Synthesized by a Single Non-ribosomal Peptide Synthetase of Trichoderma virens

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