Peptide and protein PEGylation

Veronese, Francesco M.

doi:10.1016/s0142-9612(00)00193-9

Cited by 979 publications

(469 citation statements)

References 63 publications

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“…This results in inert hydrophilic surfaces with less 'stickyness'. The same applies for molecules or particles: PEG-modified proteins (Veronese 2001) or drugs show increased water solubility and decreased immunogenicity in organisms, antibodies bind to a much lesser extent to the drug or protein, resulting e.g. in an increased half-life in the blood stream.…”

Section: (B) Poly(ethylene Glycol)mentioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,409

1,092

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Inorganic colloidal nanoparticles are very small, nanoscale objects with inorganic cores that are dispersed in a solvent. Depending on the material they consist of, nanoparticles can possess a number of different properties such as high electron density and strong optical absorption (e.g. metal particles, in particular Au), photoluminescence in the form of fluorescence (semiconductor quantum dots, e.g. CdSe or CdTe) or phosphorescence (doped oxide materials, e.g. Y 2 O 3 ), or magnetic moment (e.g. iron oxide or cobalt nanoparticles). Prerequisite for every possible application is the proper surface functionalization of such nanoparticles, which determines their interaction with the environment. These interactions ultimately affect the colloidal stability of the particles, and may yield to a controlled assembly or to the delivery of nanoparticles to a target, e.g. by appropriate functional molecules on the particle surface. This work aims to review different strategies of surface modification and functionalization of inorganic colloidal nanoparticles with a special focus on the material systems gold and semiconductor nanoparticles, such as CdSe/ZnS. However, the discussed strategies are often of general nature and apply in the same way to nanoparticles of other materials.

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Section: (B) Poly(ethylene Glycol)mentioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,409

1,092

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“…13 The possibility to obtain polymers with a narrow molecular weight distribution is also a crucial parameter as polydisperse polymers reflect in polydispersity of the target polypeptide-polymer conjugate. 4 An acetal initiator has been previously used for living anionic ring opening polymerization of ethylene oxide to give aldehyde functional polymers 14 ; it is noted that living radical polymerization is extremely diverse in the number of potential monomers in addition to being robust towards protic groups in the system. 13 Our synthetic strategy is summarized in Scheme 3.…”

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confidence: 99%

α-Aldehyde Terminally Functional Methacrylic Polymers from Living Radical Polymerization: Application in Protein Conjugation “Pegylation”

et al. 2004

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Application of proteins and peptides as human therapeutics is expanding rapidly as drug discovery becomes more prevalent. Conjugation of polymers to proteins can circumvent many problems and pegylation of proteins is now emerging as acceptable practice. This paper describes the synthesis of α-aldehyde-terminated poly(methoxyPEG)methacrylates from Cu(I) mediated living radical polymerization (M n = 11 000, 22 000 and 32 000; PDi < 1.15), and their efficient conjugation to lysozyme, as a model protein. This offers an attractive and flexible alternative to linear poly(ethylene glycol) opening up the possibility of using the full power of living radical polymerization.

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“…[59,93,94] One of the most common polymers used in therapeutic applications is poly(ethylene glycol) (PEG), which has been FDA approved for use in cosmetics and medicine. [93,95] PEG conjugation (also known as PEGylation) of therapeutic peptides and proteins is a very effective way to prolong the lifetime of these drugs. While initial PEGylation efforts resulted in diminished therapeutic activity of the peptide/protein drug, recent site-specific PEGylation strategies have permitted access to formulations with minimal loss in activity while prolonging the therapeutic lifetime.…”

Section: Polymer Conjugated Entry and Fusion Inhibitorsmentioning

confidence: 99%

Polymeric Anti‐HIV Therapeutics

Danial

Klok

2014

Macromolecular Bioscience

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The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted. After that, a comprehensive overview of the structure and inhibitory properties of polymeric anti‐HIV therapeutic agents is presented. This overview will include inhibitors based on polysaccharides, synthetic polymers, dendritic polymers, polymer conjugates as well as polymeric DC‐SIGN antagonists. The review will conclude with a section that discusses the applications of polymers and polymer conjugates as systemic and topical anti‐HIV therapeutics.

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Peptide and protein PEGylation

Cited by 979 publications

References 63 publications

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

α-Aldehyde Terminally Functional Methacrylic Polymers from Living Radical Polymerization: Application in Protein Conjugation “Pegylation”

Polymeric Anti‐HIV Therapeutics

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