Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells

Kadioglu, Onat; Efferth, Thomas

doi:10.1007/s10637-016-0339-6

Cited by 24 publications

(20 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies report that a genomic amplification of the ABCB1-containing chromosomal region 7q21.12 occurs in MD-resistant cancers and that overexpression of genes of such region contributes to MDR ( Figure 5) [51,72,[119][120][121][122][123][124][125][126][127][128][129][130][131]. Amplification of the chromosomal region 7q21 containing ABCB1 and SRI (sorcin gene) was described in multidrug-resistant leukemia, neuroblastoma, and lung tumor cells [122,125,132]. The amplicon includes the genes SRI, ADAM22, DBF4, SLC25A40, RUNDC3B (RPIP9), ABCB1, ABCB4, CROT, the TP53TG1 long non-coding RNA, TMEM243 and DMTF1 ( Figure 5), all of which were found to be associated with carcinogenesis and MDR.…”

Section: Sorcin Expression and Abcb1 Expression Are Linkedmentioning

confidence: 99%

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

Battista

Fiorillo

Chiarini

et al. 2020

Cancers

View full text Add to dashboard Cite

The development of drug resistance is one of the main causes of failure in anti-cancer treatments. Tumor cells adopt many strategies to counteract the action of chemotherapeutic agents, e.g., enhanced DNA damage repair, inactivation of apoptotic pathways, alteration of drug targets, drug inactivation, and overexpression of ABC (Adenosine triphosphate-binding cassette, or ATP-binding cassette) transporters. These are broad substrate-specificity ATP-dependent efflux pumps able to export toxins or drugs out of cells; for instance, ABCB1 (MDR1, or P-glycoprotein 1), overexpressed in most cancer cells, confers them multidrug resistance (MDR). The gene coding for sorcin (SOluble Resistance-related Calcium-binding proteIN) is highly conserved among mammals and is located in the same chromosomal locus and amplicon as the ABC transporters ABCB1 and ABCB4, both in human and rodent genomes (two variants of ABCB1, i.e., ABCB1a and ABCB1b, are in rodent amplicon). Sorcin was initially characterized as a soluble protein overexpressed in multidrug (MD) resistant cells and named “resistance-related” because of its co-amplification with ABCB1. Although for years sorcin overexpression was thought to be only a by-product of the co-amplification with ABC transporter genes, many papers have recently demonstrated that sorcin plays an important part in MDR, indicating a possible role of sorcin as an oncoprotein. The present review illustrates sorcin roles in the generation of MDR via many mechanisms and points to sorcin as a novel potential target of different anticancer molecules.

show abstract

Section: Sorcin Expression and Abcb1 Expression Are Linkedmentioning

confidence: 99%

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

Battista

Fiorillo

Chiarini

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…This effect is associated with an increase in P53 levels (Acunzo et al 2014;Baylot et al 2012). In addition, recently a peptide aptamer (WGQWPYHC) targeting TCTP was tested and found to display specific cytotoxicity towards TCTP expressing tumour cells, without affecting normal cells (Kadioglu and Efferth 2016).…”

Section: Tctp As An Anticancer Targetmentioning

confidence: 99%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

View full text Add to dashboard Cite

The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

show abstract

“…In many types of cancers, amplification of the chromosome 7q21 region containing genes of ABCB1 and Sorcin, has been reported in MD-resistant cell lines as neuroblastoma [116] , lung cancer cells [117] and leukemia cells [118] . Often, genomic instability and chromosomal rearrangements result in genomic amplification, yielding an increase in the ABCB1 gene copy number and transactivation of ABCB1 overexpression [119][120][121][122][123][124] .…”

Section: The Sri Gene Resides In the Abcb1 Amplicon: Gene Coamplificamentioning

confidence: 99%

Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents

Genovese¹,

Ilari²,

Battista³

et al. 2018

CDR

View full text Add to dashboard Cite

Soluble resistance-related calcium binding protein (Sorcin) is a protein initially labelled "resistance-related", since it is co-amplified with ABCB1 in multidrug (MD)-resistant cells. While for years Sorcin overproduction was believed to be a by-product of the co-amplification of its gene with the P-glycoprotein gene, many recent studies view Sorcin as an oncoprotein, playing an important role in MD resistance (MDR). Sorcin is one of the most highly expressed calciumbinding proteins, which is overexpressed in many human tumors and MD resistant cancers, and represents a novel MDR marker. Sorcin expression in tumors inversely correlates with patients' response to chemotherapies and overall prognosis. Sorcin is highly expressed in MDR cell lines over their parent cells. Sorcin overexpression by gene transfection increases drug resistance to a variety of chemotherapeutic drugs in many cancer lines. On the other hand, Sorcin silencing leads to reversal of drug resistance in many cell lines. This review describes: (1) the roles of Sorcin in the cell; (2) the studies showing Sorcin overexpression in tumors and cancer cells; (3) the studies showing the effects of Sorcin overexpression and silencing; (4) the molecular effects of Sorcin overexpression; and (5) the structural and genetic bases of Sorcin-dependent MDR.

show abstract

Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells

Cited by 24 publications

References 57 publications

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents

Contact Info

Product

Resources

About