Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-l-lysine dendrons

Rosli, Nurlina; Christie, Michelle P.; Moyle, Peter M.; Tóth, István

doi:10.1016/j.bmc.2015.03.058

Cited by 8 publications

(1 citation statement)

References 45 publications

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“…PLL dendrons have been used as scaffolds for presenting multiple peptide epitopes to the immune system. Such molecules consist of an inner matrix constructed from several layers of lysines connected via α- and ε-amino groups [ 213 ]. Two amino groups of lysines that are located at the surface of molecule can be orthogonally substituted by one or two different ligands (e.g., peptide chains).…”

Section: Antifungal Peptidesmentioning

confidence: 99%

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

Bondaryk

Staniszewska

Zielińska

et al. 2017

JoF

106

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Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides.

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Section: Antifungal Peptidesmentioning

confidence: 99%