Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin

Gallo, Enrico; Diaferia, Carlo; Rosa, Elisabetta; Smaldone, Giovanni; Morelli, Giancarlo; Accardo, Antonella

doi:10.2147/ijn.s296272

Cited by 59 publications

(43 citation statements)

References 52 publications

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“…On the opposite side, the lipophilic curcumin exhibited a more sustained release and favored the interaction with the peptide nanofiber network, therefore leading to a more retarded release. Short to ultra-short peptide hydrogels have already been used to deliver antitumor drugs such as doxorubicin [60][61][62] and curcumin [63][64][65]. In most cases, the synthesized peptides are based on the homodipeptide FF or its modified natural or unnatural amino acids, like napthylalanine.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, doxorubicin entrapped in a short nucleo-peptide hydrogel (Ade-FFF) released at a sustained rate (55% over 12 days) [66]. Other researchers used doxil instead of doxorubicin hydrochloride, so their results are not comparable, as doxil (the liposomal formula of doxorubicin) is expected to exhibit a different release rate [61]. Four different α,β-dehydrophenylalanine dipeptide nanotubes were used to encapsulate curcumin and investigate the management of malaria [64].…”

Section: Discussionmentioning

confidence: 99%

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NGIWY-Amide: A Bioinspired Ultrashort Self-Assembled Peptide Gelator for Local Drug Delivery Applications

et al. 2022

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Fibrillar structures derived from plant or animal origin have long been a source of inspiration for the design of new biomaterials. The Asn-Gly-Ile-Trp-Tyr-NH2 (NGIWY-amide) pentapeptide, isolated from the sea cucumber Apostichopus japonicus, which spontaneously self-assembles in water to form hydrogel, pertains to this category. In this study, we evaluated this ultra-short cosmetic bioinspired peptide as vector for local drug delivery applications. Combining nuclear magnetic resonance, circular dichroism, infrared spectroscopy, X-ray diffraction, and rheological studies, the synthesized pentapeptide formed a stiff hydrogel with a high β-sheet content. Molecular dynamic simulations aligned well with scanning electron and atomic-force microscopy studies, revealing a highly filamentous structure with the fibers adopting a helical-twisted morphology. Model dye localization within the supramolecular hydrogel provided insights on the preferential distribution of hydrophobic and hydrophilic compounds in the hydrogel network. That was further depicted in the diffusion kinetics of drugs differing in their aqueous solubility and molecular weight, namely, doxorubicin hydrochloride, curcumin, and octreotide acetate, highlighting its versatility as a delivery vector of both hydrophobic and hydrophilic compounds of different molecular weight. Along with the observed cytocompatibility of the hydrogel, the NGIWY-amide pentapeptide may offer new approaches for cell growth, drug delivery, and 3D bioprinting tissue-engineering applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

NGIWY-Amide: A Bioinspired Ultrashort Self-Assembled Peptide Gelator for Local Drug Delivery Applications

et al. 2022

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“…In the diagnosis of pathology, the fluorescence effect of peptide derivatives can effectively show amyloidosis [86]. Moreover, metal ion-excited peptide gels have better responsiveness and a wider range of clinical applications [87][88][89].…”

Section: Other Application Of Peptide-based Hydrogelsmentioning

confidence: 99%

Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides

Zhang

et al. 2021

Gels

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Peripheral nerve injury often occurs in young adults and is characterized by complex regeneration mechanisms, poor prognosis, and slow recovery, which not only creates psychological obstacles for the patients but also causes a significant burden on society, making it a fundamental problem in clinical medicine. Various steps are needed to promote regeneration of the peripheral nerve. As a bioremediation material, self-assembled peptide (SAP) hydrogels have attracted international attention. They can not only be designed with different characteristics but also be applied in the repair of peripheral nerve injury by promoting cell proliferation or drug-loaded sustained release. SAP hydrogels are widely used in tissue engineering and have become the focus of research. They have extensive application prospects and are of great potential biological value. In this paper, the application of SAP hydrogel in peripheral nerve injury repair is reviewed, and the latest progress in peptide composites and fabrication techniques are discussed.

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“…Besides, aromatic motif phenylalanine-phenylalanine (FF) also often is used for constructing suparmolecular nanomaterials to improve self-assembly capability and regularize molecular arrangement (Ryan et al, 2015;Diaferia et al, 2019;Gallo et al, 2021;Li et al, 2021). In this study, we fabricated an RGD peptide-conjugated, self-assembling, and FFbased supramolecular nanoparticle mainly formed by PEM to concurrently enhance active targeting and anticancer efficiency toward tumors.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we fabricated an RGD peptide-conjugated, self-assembling, and FFbased supramolecular nanoparticle mainly formed by PEM to concurrently enhance active targeting and anticancer efficiency toward tumors. As the self-assembly peptides are promising organic materials, which are widely applied in tissue engineering, drug delivery systems and biomaterials for they showed improved mechanical properties, stability, hydrophilicity and good biocompatibility (Ryan et al, 2015;Diaferia et al, 2019;Gallo et al, 2021;Li et al, 2021). PEM-FFRGD were synthesized with a method of standard solid phase peptide synthesis, and the PEM-FFRGD monomers can easily form into particle-like nanostructure via PH adjust and ultrasound method.…”

Section: Introductionmentioning

confidence: 99%

A Supramolecular Nanoparticle of Pemetrexed Improves the Anti-Tumor Effect by Inhibiting Mitochondrial Energy Metabolism

Liu¹,

Guo²,

Shang³

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, supramolecular nanoparticles consisting of peptides and drugs have been regarded as useful drug delivery systems for tumor therapy. Pemetrexed (PEM) is a multitarget drug that is effective for many cancers, such as non-small cell lung cancer. Here, RGD-conjugated molecular nanoparticles mainly composed of an anticancer drug of PEM (PEM-FFRGD) were prepared to deliver PEM to tumors. The peptide could self-assemble into a nanoparticle structure with diameter of about 20 nm. Moreover, the nanoparticle showed favorable solubility and biocompatibility compared with those of PEM, and the MTT test on A549 and LLC cells showed that the PEM-FFRGD nanoparticles had stronger cytotoxic activity than PEM alone. Most importantly, the nanoparticle could promote tumor apoptosis and decrease mitochondrial energy metabolism in tumors. In vivo studies indicated that PEM-FFRGD nanoparticles had enhanced antitumor efficacy in LLC tumor-bearing mice compared to that of PEM. Our observations suggested that PEM-FFRGD nanoparticles have great practical potential for application in lung cancer therapy.

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Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin

Cited by 59 publications

References 52 publications

NGIWY-Amide: A Bioinspired Ultrashort Self-Assembled Peptide Gelator for Local Drug Delivery Applications

NGIWY-Amide: A Bioinspired Ultrashort Self-Assembled Peptide Gelator for Local Drug Delivery Applications

Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides

A Supramolecular Nanoparticle of Pemetrexed Improves the Anti-Tumor Effect by Inhibiting Mitochondrial Energy Metabolism

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