Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and <i>vice versa</i>

Redondo-Gómez, Carlos; Parreira, Paula; Martins, M. Cristina L.; Azevedo, Helena S.

doi:10.1039/d3cs00921a

Cited by 4 publications

(1 citation statement)

References 309 publications

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“…[51], are initiators for immunoactivity molecule immobilization. Few reports of self-assembled monolayers are one of the promising alternatives for protein (antigen or antibody, protein of interest) immobilization [52,53]. Sulphur donor atoms strongly coordinate on various noble substrates such as sulphides, disulfides, and thiols, which are perfectly organized.…”

Section: Functional Model Of Bonding Between the Protein And The Unde...mentioning

confidence: 99%

Modelling Prospects of Bio-Electrochemical Immunosensing Platforms

Gandhi

2024

Electrochem

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Electrochemistry is a hotspot in today’s research arena. Many different domains have been extended for their role towards the Internet of Things, digital health, personalized nutrition, and/or wellness using electrochemistry. These advances have led to a substantial increase in the power and popularity of electroanalysis and its expansion into new phases and environments. The recent COVID-19 pandemic, which turned our lives upside down, has helped us to understand the need for miniaturized electrochemical diagnostic platforms. It also accelerated the role of mobile and wearable, implantable sensors as telehealth systems. The major principle behind these platforms is the role of electrochemical immunoassays, which help in overshadowing the classical gold standard methods (reverse transcriptase polymerase chain reaction) in terms of accuracy, time, manpower, and, most importantly, economics. Many research groups have endeavoured to use electrochemical and bio-electrochemical tools to overcome the limitations of classical assays (in terms of accuracy, accessibility, portability, and response time). This review mainly focuses on the electrochemical technologies used for immunosensing platforms, their fabrication requirements, mechanistic objectives, electrochemical techniques involved, and their subsequent output signal amplifications using a tagged and non-tagged system. The combination of various techniques (optical spectroscopy, Raman scattering, column chromatography, HPLC, and X-ray diffraction) has enabled the construction of high-performance electrodes. Later in the review, these combinations and their utilization will be explained in terms of their mechanistic platform along with chemical bonding and their role in signal output in the later part of article. Furthermore, the market study in terms of real prototypes will be elaborately discussed.

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Section: Functional Model Of Bonding Between the Protein And The Unde...mentioning

confidence: 99%

Modelling Prospects of Bio-Electrochemical Immunosensing Platforms

Gandhi

2024

Electrochem

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Incorporation of phenylcarbonyl groups in the sidechain: A tool to induce ordered assembly of peptides on surfaces

Kalita,

Yadav,

Archana

et al. 2024

Journal of Peptide Science

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The possibility of introducing various functionalities on peptides with relative ease allows them to be used for molecular applications. However, oligopeptides prepared entirely from proteinogenic amino acids seldom assemble as ordered structures on surfaces. Therefore, sidechain modifications of peptides that can increase the intermolecular interactions without altering the constitution of a given peptide become an attractive route to self‐assembling them on surfaces. We find that replacing phenylalanine residues with unusual amino acids that have phenylcarbonyl sidechains in oligopeptides increases the formation of ordered self‐assembly on a highly ordered pyrolytic graphite surface. Peptides containing the modified amino acids provided extended long‐range ordered assemblies, while the analogous peptides containing phenylalanine residues failed to form long‐range assemblies. X‐ray crystallographic analysis of the bulk structures of these peptides and the analogous peptides containing phenylalanine residues reveal that such modifications do not alter the secondary structure in crystals. It also reveals that the secondary hydrogen bonding interaction through phenylcarbonyl sidechains facilitates extended growth of the peptides on graphite.

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Quantitative electrochemical and SEIRA characterization of mercaptosuccinic acid monolayer on gold surface

Su,

Królikowska,

Seenath

et al. 2024

Electrochimica Acta

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Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

Abstract: Self-assembled monolayers (SAMs) based on peptides represent a reproducible platform for screening and studying peptide functions and facilitating their translation into multidisciplinary applications.

Cited by 4 publications

References 309 publications

Modelling Prospects of Bio-Electrochemical Immunosensing Platforms

Modelling Prospects of Bio-Electrochemical Immunosensing Platforms

Incorporation of phenylcarbonyl groups in the sidechain: A tool to induce ordered assembly of peptides on surfaces

Quantitative electrochemical and SEIRA characterization of mercaptosuccinic acid monolayer on gold surface

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