Peptide containing microspheres from low molecular weight and hydrophilic poly(d,l-lactide-co-glycolide)

Mehta, Rahul; Thanoo, B. Chithambara; DeLuca, Patrick P.

doi:10.1016/0168-3659(96)01332-6

Cited by 155 publications

(102 citation statements)

References 12 publications

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“…Encapsulation efficiency increases with increasing polymer concentration (Mehta et al, 1996;Rafati et al, 1997;Li et al, 1999). For example, the encapsulation efficiency increased from 53.1 to 70.9% when concentration of the polymer increased from 20.0 to 32.5% (Mehta et al, 1996).…”

Section: Polymer Concentrationmentioning

confidence: 95%

“…For example, the encapsulation efficiency increased from 53.1 to 70.9% when concentration of the polymer increased from 20.0 to 32.5% (Mehta et al, 1996). High viscosity and fast solidification of the dispersed phase contributed to reducing porosity of the microparticles as well (Schlicher et al, 1997).…”

Section: Polymer Concentrationmentioning

confidence: 99%

“…According to Mehta et al, solubilities of polymers in organic solvents determines the solidification rate of the polymers during the microparticle preparation process, which in turn affects microparticle properties such as drug incorporation, matrix porosity, and solvent residues (Mehta et al, 1996). Eleven low molecular weight PLGA (ratio of …”

Section: Solubility Of Polymer In Organic Solventmentioning

confidence: 99%

“…In Mehta's study, polymers having relatively high solubilities in methylene chloride took longer to solidify and resulted in low encapsulation efficiencies, and vice versa (Mehta et al, 1996). Particle size and bulk density also varied according to the polymer.…”

Section: Fig 2 Factors Influencing Encapsulation Efficiencymentioning

confidence: 99%

“…In most cases, the burst release is due to poor control over the diffusionbased release in this stage. The degree of initial burst from the microparticles depends on the ability of the polymer matrix to encapsulate the protein, thereby making it unavailable for immediate diffusion (Mehta et al, 1996). For this reason, efforts to reduce the initial burst have followed in the same track as those to increase encapsulation efficiency.…”

Section: Introductionmentioning

confidence: 99%

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Control of encapsulation efficiency and initial burst in polymeric microparticle systems

2004

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Initial burst is one of the major challenges in protein-encapsulated microparticle systems. Since protein release during the initial stage depends mostly on the diffusional escape of the protein, major approaches to prevent the initial burst have focused on efficient encapsulation of the protein within the microparticles. For this reason, control of encapsulation efficiency and the extent of initial burst are based on common formulation parameters. The present article provides a literature review of the formulation parameters that are known to influence the two properties in the emulsion-solvent evaporation/extraction method. Physical and chemical properties of encapsulating polymers, solvent systems, polymer-drug interactions, and properties of the continuous phase are some of the influential variables. Most parameters affect encapsulation efficiency and initial burst by modifying solidification rate of the dispersed phase. In order to prevent many unfavorable events such as pore formation, drug loss, and drug migration that occur while the dispersed phase is in the semi-solid state, it is important to understand and optimize these variables.

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Section: Polymer Concentrationmentioning

confidence: 95%

Section: Polymer Concentrationmentioning

confidence: 99%

Section: Solubility Of Polymer In Organic Solventmentioning

confidence: 99%

Section: Fig 2 Factors Influencing Encapsulation Efficiencymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Control of encapsulation efficiency and initial burst in polymeric microparticle systems

2004

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Scaffolds for Cell and Tissue Engineering

Jones

2006

Wiley Encyclopedia of Biomedical Engineering

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The aim of tissue engineering is to combine the disciplines of engineering and biology to help the body's own regenerative mechanisms to repair diseased or damaged tissue to its original state and function. One strategy is to seed a patient's progenitor cells on a scaffold, which will act as a support and stimulus of tissue growth. The cells will lay down tissue in the shape of the scaffold and this biocomposite can be implanted into a defect with the scaffold dissolving as the tissue regenerates. Scaffold design is one of the important aspects of this strategy and will be discussed in this entry. The entry discusses the criteria for an ideal scaffold and the use of bioinert, bioresorble, and bioactive materials. The use of polymers, ceramics, glasses, and composites as scaffold materials and the processing techniques used to create tissue scaffolds are described and the advantages of using each material and each processing technique are discussed.

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