Peptide Functionalized Gold Nanoparticles with Optimized Particle Size and Concentration for Colorimetric Assay Development: Detection of Cardiac Troponin I

Liu, Xiaohu; Wang, Yi; Peng, Chen; McCadden, Austin; Palaniappan, Alagappan; Zhang, Jinling; Liedberg, Bo

doi:10.1021/acssensors.6b00493

Cited by 83 publications

(55 citation statements)

References 32 publications

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“…by employing a specific surface functionalization (e.g., antibodies, peptide, and aptamers), these functional plasmonic NPs can be assembled as a rapid and sensitive detection kit for a wide range of diseases. [ 79 ] Even with such progresses, critical challenges are being addressed in terms of signal intensity, penetration depth, and resolution needed to be thoroughly considered before moving toward clinical translation.…”

Section: Applications Of Plasmonic Npsmentioning

confidence: 99%

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Wang

Kafshgari

Meunier

2020

Adv Funct Materials

399

234

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Noble metal nanoparticles due to their unique optical properties arising from their interactions with an incident light have been intensively employed in a broad range of applications. This review comprehensively describes fundamentals behind plasmonics, used to develop applications in the fields of biomedical, energy, and information technologies. Basic concepts (electromagnetic interaction and permittivity of metals) are discussed through Mie theory presented as the main model for interpreting phenomena of optical absorption and scattering. The effects of near‐field enhancement, shape, composition, and surrounding medium of nanoparticles on optical properties are described in detail. The review explores and identifies the potential of plasmonic nanoparticles based on their optical properties (e.g., light absorption, scattering, and field enhancement) for developing different applications (biomedical, energy and information technologies). Due to a significant impact of plasmonic nanoparticles on medicine and healthcare products and technologies, the review initially focuses on biomedical applications extensively benefited from optical features of these nanoparticles. Advantages of the optical properties outstandingly implemented are also briefly discussed in other applications, including energy and information technologies. This review concisely summarizes the explored areas based on plasmonic properties, compares advantages of plasmonic nanoparticles over other types of nanomaterials and highlights challenges.

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Section: Applications Of Plasmonic Npsmentioning

confidence: 99%

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Wang

Kafshgari

Meunier

2020

Adv Funct Materials

399

234

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“…10–13 Well-developed chemistry to introduce various functional groups and ligands to NPs has been further adopted for the creation of diverse platform for specific biomimetic interactions. 14–20 The biomimetic metal NPs therefore offer a great potential for staging the active part of a large biomolecule with improved stability, which is often a problem for enzymes (denaturation and digestion). 1 …”

Section: Introductionmentioning

confidence: 99%

Effects of Noncovalent Interactions on the Catalytic Activity of Unsupported Colloidal Palladium Nanoparticles Stabilized with Thiolate Ligands

Maung

Shon

2017

J. Phys. Chem. C

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This article presents the systematic evaluation of colloidal palladium nanoparticles functionalized with well-defined small organic ligands that provide spatial control of the geometric and electronic surface properties of nanoparticle catalysts. Palladium nanoparticles stabilized with thiolate ligands of different structures and functionalities (linear alkyl vs cyclohexyl vs phenyl) are synthesized using the thiosulfate protocol in a two-phase system. The structure and composition of palladium nanoparticles are characterized using transmission electron microscopy, thermogravimetric analysis, NMR, and UV–vis spectroscopies. The catalysis studies show that the chemical and structural compositions of monolayers surrounding the nanoparticle core greatly influence the overall activity and selectivity of colloidal palladium nanoparticle catalysts for the hydrogenation, isomerization, and hydrogenolysis of allylic alcohols. Especially, noncovalent interactions between surface phenyl ligands and incoming aromatic substrates are found to have a profound influence on the selectivity of colloidal palladium nanoparticles.

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“…reported a direct binding induced AuNP aggregation assay for human cardiac troponin I (cTnI) protein. [ 157 ] The specific peptide binder (FYSHSFHENWPS) was adopted from previous study [ 158 ] and modified onto AuNP surface mixed with spacer peptide. Immediately after the addition of target protein, peptide‐functionalized AuNP aggregated which resulted in a concomitant UV–visible spectral peak‐shift and color change ( Figure A).…”

Section: Targeting Molecules Via Peptide–gold Hybrid Nanomaterialsmentioning

confidence: 99%

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

et al. 2020

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Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing‐related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide–AuNP‐based bio‐nano‐technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide–gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide–gold nanomaterials with functional properties are discussed along with future challenges and opportunities.

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Peptide Functionalized Gold Nanoparticles with Optimized Particle Size and Concentration for Colorimetric Assay Development: Detection of Cardiac Troponin I

Cited by 83 publications

References 32 publications

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Optical Properties and Applications of Plasmonic‐Metal Nanoparticles

Effects of Noncovalent Interactions on the Catalytic Activity of Unsupported Colloidal Palladium Nanoparticles Stabilized with Thiolate Ligands

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

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