Peptide therapy and the gastroenterologist: colostrum and milk-derived growth factors

PLAYFORD, R

doi:10.1054/clnu.2001.0434

Cited by 21 publications

(19 citation statements)

References 48 publications

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“…immediately after parturition (Levieux and Ollier 1999;Nakamura et al 2003;Godhia and Patel 2013), 2 days (Playford et al 2000;Playford 2001), 3 to 4 days (Foley and Otterby 1978;Gopal and Gill 2000;Davis et al 2007;Zhang et al 2011) or 5 to 7 days post-partum (Marnila and Korohnen 2002;Georgiev 2008;Zarcula et al 2010;Abd ElFattah et al 2012). For the purposes of this review, colostrum, unless otherwise defined, will refer to the early milkings from dairy cows, taken up to 3 days post-partum.…”

Section: Introductionmentioning

confidence: 99%

Composition and properties of bovine colostrum: a review

McGrath

Fox

McSweeney

et al. 2015

Dairy Sci. & Technol.

315

263

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Colostrum is the initial milk secreted by mammals following parturition, the composition and physicochemical properties of which are highly dynamic and variable. The composition and physicochemical properties of colostrum during the initial postpartum period has not been systematically reviewed for many years, although the topic remains of interest both to milk producers and processors. In this article, the current understanding of the composition of colostrum, i.e. carbohydrates, proteins, growth factors, enzymes, enzyme inhibitors, nucleotides and nucleosides, cytokines, fats, vitamins and minerals, is reviewed. In addition, the physicochemical properties, i.e. pH and buffering capacity, colour, density and specific gravity, osmotic pressure, somatic cell count, properties of casein micelles, ethanol stability and rennet coagulation properties are discussed, as well as the effects of heat-treating colostrum.

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Section: Introductionmentioning

confidence: 99%

Composition and properties of bovine colostrum: a review

McGrath

Fox

McSweeney

et al. 2015

Dairy Sci. & Technol.

315

263

View full text Add to dashboard Cite

show abstract

“…There is a large body of scientific data that supports the hypothesis that dietary supplementation with bovine colostrum can provide broad ranging immune modulation and have an impact on the severity of a range of disorders such as inflammatory bowel disease, liver disease, ulcerative colitis and infective diarrhea [30,48,49]. In contrast, the ability of bovine colostrum to specifically support stem cell associated regenerative pathways following consumption is not well established, although there is evidence that is indicative these types of activity.…”

Section: Discussionmentioning

confidence: 99%

Developing a commercially viable process for an Active Pharmaceutical Ingredient, Challenges, Myths and Reality in the Art of Process Chemistry

Gill¹

2013

TONUTRAJ

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Abstract:There is increasing interest in the use of functional foods to activate natural stem cell associated repair pathways resulting in improved health and well-being. Bovine Alpha Lipid colostrum, a proprietary formulation, induced stem cell associated cytokines and growth factor, GCSF, IL-6 and VEGF and also enhanced the differentiation of bone marrow stem cells in vitro. To boost colostrum activity, commercially available natural extracts of immune stimulatory carbohydrates were screened for their capacity to induce GCSF and IL-6. Combining selected extracts with colostrum, showed synergistic cytokine induction in vitro. In a mouse feeding study, a trial formulation of Alpha Lipid colostrum combined with selected carbohydrate extracts, was shown to increase the frequency of bone marrow hematopoietic stem cells to a greater extent that was seen with the colostrum alone, as assessed by CFU assay. Furthermore, a pilot human study showed there were alterations in circulating hematopoietic and mesenchymal/stromal stem cell numbers following consumption of the trial formulation compared to subjects receiving a placebo supplement. These data indicate that is possible to influence the endogenous stem cell niche by oral supplementation with a combination of colostrum and highly potent sources of immune stimulatory carbohydrates.

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“…Bovine colostrum due to content of these antimicrobial components has been tested for the treatment and prevention of various infectious diseases caused by bacteria, viruses and protozoa [3]. Oligosaccharides with prebiotic effect are naturally present in colostrum and can improve the growth of probiotic microorganisms such as lactobacilli and bifidobacteria [4].…”

Section: Introductionmentioning

confidence: 99%