Peptide YY: A Gut Hormone Associated with Anorexia during Infectious Diarrhea in Children

Abstract

Objective-To evaluate the effects of diarrhea on appetite among Peruvian children ages 12 to 71 months and to assess whether elevated plasma levels of peptide YY, TNF-α, and IL-1β contribute to anorexia in this population. Study design-46Peruvian children with diarrhea and 46 healthy controls underwent an observed feeding trial that was repeated when cases were healthy. Blood was taken from 30 cases Corresponding Author: Amy Beck, 414 Warren Dr. #3 San Francisco, CA 94131, Phone:(203) Fax: (415) . Reprint request author: Amy BeckPublisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript and controls at the first trial and from 30 cases at the second trial and was assayed for peptide YY, TNF-α, and IL-1β.Results-The mean consumption of cases when sick was less than when healthy. The mean plasma level of peptide YY was higher for cases than controls and higher for cases when sick compared with cases when healthy. TNF-α levels were higher in cases than controls at visit 1 and also higher in cases when sick than when healthy. There were no differences in IL-1β levels between cases and controls or between cases when sick and healthy. Peptide YY levels in children with diarrhea correlated with the likelihood of them eating less when sick compared with when healthy.Conclusions-Elevated serum peptide YY may be a mechanism for anorexia among children with diarrhea. Keywordsappetite; gastroenteritis; malnutrition; gut hormone Diarrheal illness is a major cause of malnutrition among children in the developing world (1,2,3,4). Proposed mechanisms by which diarrhea may cause malnutrition include malabsorption of nutrients, increased metabolic demand and decreased intake from diarrheaassociated anorexia. The question of whether diarrhea leads to a decrease in appetite in children is particularly important to address because anorexia may thwart caregivers' attempts to ensure adequate caloric intake during diarrheal episodes.Observational community studies of infants and toddlers in Nigeria and Peru found that solid food intake was significantly decreased during diarrhea while breast milk intake was unchanged (5,6). In a hospital based study in Bangladesh, children with diarrhea ate nearly 50% less than healthy controls, mostly as a result of decreased intake of non-breast milk sources (7). None of the existing studies on diarrhea and appetite attempted to determine the mechanism of anorexia.Hormonal control of appetite has been a major topic of investigation in recent years leading to the discove...

Gut Hormones, Appetite Suppression and Cachexia in Patients with Pulmonary TB

“…To prevent breakdown of PYY and ghrelin by proteases, tubes were prepared with aprotinin prior to blood draw according to published protocols [10].…”

“…High PYY levels have been linked to decreased appetite and food intake [7]. PYY is elevated in patients with malabsorptive disorders such as inflammatory bowel disease [8], celiac sprue [9], and infectious diarrhea [10], and in patients with anorexia nervosa and cancer in the absence of known GI illness [11], [12]. Dysregulation in PYY secretion could therefore be associated with decreased food intake and subsequent weight loss in a range of disease processes.…”

The Level of Peptide YY in Blood Serum of Children With ChronicConstipation: A Cross-Sectional Study

“…В работе A. Beck и соавт. уровень пептида YY в плазме здоровых детей составил 33,5 ± 16,4 мкг/мл, но сравнить с нашими результатами не представляется возможным, так как определение пептидного гормона проводили разными методиками (иммуноферментный и радиоиммунологический анализы) [19].…”