Peptides derived from fermented soybean meal suppresses intestinal inflammation and enhances epithelial barrier function in piglets

Chen, Shan; Zong, Xin; Shi, Chao; Wang, Fengqin; Wang, Yizhen; Lu, Zeqing

doi:10.1080/09540105.2019.1705766

Cited by 35 publications

(19 citation statements)

References 44 publications

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“…TJ was a multi-protein complex composed of the claudin family, Occludin, junctional adhesion molecule, zonulin, and scaffold proteins ZO-1 (Vaarala, 2011). Among them, the claudin, Occludin and ZO-1 were associated with the intestinal barrier (Suzuki, 2013;Zhang et al, 2020). The early onset of autoimmune diabetes in BB-rats was associated with high gut permeability (Visser et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice

Sun

Liang

Xue

et al. 2020

Food and Agricultural Immunology

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This study was to evaluate the protective effect of fucoidan on the intestinal mucosal barrier in non-obese diabetic mice (NOD). Twenty NOD mice were randomly assigned to two groups: the control group and the fucoidan intervention group which were fed with fucoidan at a concentration of 600 mg/kg BW (body weight) per day for five weeks. Mice treated with fucoidan had a significant improvement in glycemic control, and the proportions of Th1/Th2/Th17 cells and the levels of endotoxin, DAO and D-LA were reduced. Fucoidan treatment improved intestinal barrier function by increasing ZO-1, claudin-1 and Occludin protein expression. Moreover, the expression levels of phosphorylated ERK1/2, NF-кB p65 and p38 MAPK were decreased. Our result suggested that pre-treatment with fucoidan could attenuate the inflammatory response and maintain intestinal barrier function in NOD mice. Fucoidan-based functional food may be potential for the prevention of T1DM (type 1 diabetes mellitus).

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Section: Discussionmentioning

confidence: 99%

Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice

Sun

Liang

Xue

et al. 2020

Food and Agricultural Immunology

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“…Fermented feeds were reported to enhance the intestinal barrier and immune function in poultry (79). Herein, improving the function of TJs may be attributed to the production of fermentation bioactive components such as oligosaccharides, isoflavones, and peptides, which protect intestinal cells and support their recovery (80). In addition to the presence of probiotic bacteria in fermented feed, TJ integrity and mucus secretion occurred in the gastrointestinal tract of broiler chicks.…”

Section: Figure 3 |mentioning

confidence: 99%

Performance, Serum Biochemical and Immunological Parameters, and Digestive Enzyme and Intestinal Barrier-Related Gene Expression of Broiler Chickens Fed Fermented Fava Bean By-Products as a Substitute for Conventional Feed

et al. 2021

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Improving the nutritional quality of unconventional feed ingredients such as fava bean by-products can enhance their utilization by broiler chickens. Hence, the quality of fermented fava bean by-products (FFB), in addition to growth, nutrient digestibility, digestive enzyme, and intestinal barrier-related gene expression, and serum biochemical and immunological parameters were evaluated in response to different levels of FFB. A total of 500 1-day-old broiler chicks (46.00 ± 0.388 g) were allocated to five groups with 10 replicates each (100 chicks per treatment). The first group was fed a corn–soybean diet (control diet), and the other four groups were fed a diet containing 5, 15, 25, and 35% FFB for 38 days. Birds fed 25% FFB exhibited maximum body weight gain (increase by 12.5%, compared with the control group) and the most improved feed conversion ratio. Additionally, birds fed FFB at 15, 25, and 35% showed improved dry matter and crude protein digestibility. Moreover, birds fed FFB at 25 and 35% exhibited a decrease in ileal pH and an increase in fiber digestibility (p < 0.05). Upregulation of digestive enzyme genes (AMY2A, PNLIP, and CCK) was observed in groups fed with FFB. The most prominent upregulation of genes encoding tight junction proteins (claudin-1, occludin, and junctional adhesion molecules) in the duodenum was observed in chicks fed 25 and 35% FFB (increase of 0.66-, 0.31-, and 1.06-fold and 0.74-, 0.44-, and 0.92-fold, respectively). Additionally, the highest expression level of enterocyte protective genes [glucagon-like peptide (GLP-2), mucin-2 (MUC-2), and fatty acid-binding protein (FABP-6)] was detected in duodenum of chicks fed high levels of FFB. Substitution of corn–soybean diet with FFB had an inhibitory effect on cecal pathogenic microbes (Escherichia coli and Clostridium perfringens) and increased beneficial microflora (Lactobacilli and Bifidobacterium), especially at high levels. Additionally, an increase was observed in IgM and lysozyme activity, with no effect on IgA in all groups fed FFB. All levels of FFB decreased cholesterol levels. Based on our results, we concluded that substitution of corn–soybean diet with FFB can improve the growth rate and nutrient digestibility of broiler chickens, enhance their intestinal barrier functions, and increase the number of beneficial microorganisms. Using FFB at 25% had a positive effect on the growth performance of broiler chickens, and it could be utilized in poultry farms.

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“…However, a variety of anti-nutritional factors (ANFs) present in SBM, such as antigenic proteins, trypsin inhibitors, and oligosaccharides, interfere with digestion and absorption and have negative effects on animal health [ 1 ]. Accumulating evidence has demonstrated that microbial fermentation improves the nutritional quality of SBM by reducing the content of ANFs and increasing nutrient bioavailability [ 2 , 3 , 4 ]. Fermented SBM (FSBM) is produced by the addition of fungal or bacterial microorganisms, including Lactobacillus plantarum , Bacillus subtilis , Aspergillus oryzae , and Neurospora crassa [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Fermented Soybean Meal Supplementation on the Growth Performance and Cecal Microbiota Community of Broiler Chickens

Guo

et al. 2020

Animals

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This study investigated the growth performance, serum immunity, and cecal bacterial microbiota of broilers fed a diet in which soybean meal (SBM) was partially replaced with fermented soybean meal (FSBM) for 36 days. A total of 180 one-day-old male Cobb 500 broilers were randomly divided into three dietary groups (six replicates per group): corn-SBM diet (CC); 25% SBM replaced by FSBM (SC); 50% SBM replaced by FSBM (TC). The average daily gain (ADG) and feed conversion rates (FCR) were higher in SC than CC and TC groups (p < 0.05) during the growth (d 22–36) and whole (d 1–36) phases. No significant difference was observed in ADG and average daily feed intake (ADFI) between CC and TC groups during any phases. Dietary treatments increased serum IgA, IgG, and IgM, Chao 1, observed species, and the abundance of the phylum Fimicutes but decreased the proportion of Proteobacteria (p < 0.05). Dietary treatments increased the abundance of the genera Lachnospiraceae, Lachnoclostridium, Gastranaerophilales, and Lactobacillus but decreased the abundance of Escherichia-Shigella and Clostridiales (p < 0.05). Spearman’s correlations showed that the abundance of Gastranaerophilales was positively correlated with ADG and serum immunity, and the abundance of Lactobacillus was strongly positively with IgM. Thus, replacing 25% of SBM with FSBM improves the growth performance and serum immunity of broilers, possibly due to altered cecal microbial composition.

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Peptides derived from fermented soybean meal suppresses intestinal inflammation and enhances epithelial barrier function in piglets

Cited by 35 publications

References 44 publications

Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice

Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice

Performance, Serum Biochemical and Immunological Parameters, and Digestive Enzyme and Intestinal Barrier-Related Gene Expression of Broiler Chickens Fed Fermented Fava Bean By-Products as a Substitute for Conventional Feed

Effects of Fermented Soybean Meal Supplementation on the Growth Performance and Cecal Microbiota Community of Broiler Chickens

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