Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure

It has been demonstrated that short peptides play an important role in the transmission of biological information, modulation of transcription, and restoring genetically conditioned alterations occurring with age. Peptidergic regulation of homeostasis occupies an important place in physiological processes, which lead to the aging of cells, tissues, and organs, consisting in the involution of major regulatory systems-the nervous, the endocrine, and the immune. The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis. Growth-Associated Protein 43 (GAP43), which implements neurotransmission mechanisms and neuroplasticity, demonstrated an increased expression in hPDLSCs cultured with a compound of all studied peptides and with KED alone. The peptide compound and KED, increase the expression of Nestin (neurofilament protein), expressed in early neuronal precursors in hPDLSCs cultures. Thus, the compound of peptides AEDG, KE, AED, and KED could promote the neuronal differentiation of hPDLSCs and be a promising tool for the study of peptides as a modulator of neurogenesis in neurodegenerative diseases studied in animal models.

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“…Normalized renal function in pathology model in rats. 37 in three independent experiments and three replicates for each experimental point.…”

Section: Kementioning

confidence: 99%

Effect of short peptides on neuronal differentiation of stem cells

Caputi

Trubiani

Sinjari

et al. 2019

Int J Immunopathol Pharmacol

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“…In addition, in the recent decade, an interest in synthetic oligopeptides and their use in diagnosis and treatment of different pathologies has increased dramatically; for example, investigation devoted to influence of short peptides on endothelial growth5 or protection of kidney during the cisplatin-induced acute renal failure 6…”

Section: Introductionmentioning

confidence: 99%

Cosmeceutical product consisting of biomimetic peptides: antiaging effects in vivo and in vitro

Gazitaeva¹,

Дробинцева²,

Chung³

et al. 2017

CCID

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BackgroundBiomimetic peptides are synthetic compounds that are identical to amino acid sequence synthesized by an organism and can interact with growth factor receptors and provide antiaging clinical effects.PurposeThe purpose of this study was to investigate the effects of biomimetic peptides on the repair processes in the dermis using a model of cell cultures and in vivo.Patients and methodsFive female volunteers were subjected to the injection of biomimetic peptides 1 month prior to the abdominoplasty procedure. Cell culture, immunocytochemistry, and confocal microscopy methods were used in this study.ResultsBiomimetic peptides regulate the synthesis of proteins Ki-67, type I procollagen, AP-1, and SIRT6 in cell cultures of human fibroblasts. They contribute to the activation of regeneration processes and initiation of mechanisms that prevent aging. Intradermal administration of complex of biomimetic peptides produces a more dense arrangement of collagen fibers in the dermis and increased size of the fibers after 2 weeks. The complex of biomimetic peptides was effective in the in vivo experiments, where an increase in the proliferative and synthetic activities of fibroblasts was observed.ConclusionThis investigation showed that the studied peptides have biological effects, testifying the stimulation of reparative processes in the skin under their control.

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Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging

et al. 2017

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Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal' age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.

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Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure

Cited by 9 publications

References 8 publications

Effect of short peptides on neuronal differentiation of stem cells

Effect of short peptides on neuronal differentiation of stem cells

Cosmeceutical product consisting of biomimetic peptides: antiaging effects in vivo and in vitro

Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging

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