2024
DOI: 10.3390/ijms25136918
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Peptosome: A New Efficient Transfection Tool as an Alternative to Liposome

Maliheh Manteghi,
Ozge Can,
Tanil Kocagoz

Abstract: Gene therapy is one of the most promising techniques for treating genetic diseases and cancer. The current most important problem in gene therapy is gene delivery. Viral and non-viral vectors like liposomes, used for gene delivery, have many limitations. We have developed new hybrid peptides by combining cell-penetrating peptides (CPPs) with the DNA-binding domain of the human histone H4 protein. These small peptides bind to DNA molecules through their histone domain, leaving the CPP part free and available fo… Show more

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