Per-/polyfluoroalkyl substance concentrations in human serum and their associations with liver cancer

Cao, Lei; Gao, Yu; Chen, Yuanchen; Hong, Jiawei; Wu, Jian; Jin, Hangbiao

doi:10.1016/j.chemosphere.2022.134083

Cited by 33 publications

(13 citation statements)

References 60 publications

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“…Epidemiological surveys reveal that PFOS is associated with the risk of developing cancers [ 92 ]. In a study on the relationship between PFAS concentrations in human serum and liver cancer from 2019 to 2021, the highest serum concentrations of PFOS were found in different PFAS with a 100% detection rate, and the concentration of PFOS in human serum was found to be significantly associated with the incidence of liver cancer and the levels of alpha fetoprotein (AFP), indicating that exposure to PFOS can increase the risk of developing liver cancer [ 93 ].…”

Section: Effects Of Pfos On the Liver And Related Mechanisms Of Toxicitymentioning

confidence: 99%

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Wang

Liu

Yan

et al. 2022

Toxics

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Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS can enter the human body through drinking water, ingestion of food, contact with utensils containing PFOS, and occupational exposure to PFOS, and can have adverse effects on human health. Increasing research shows that the liver is the major target of PFOS, and that PFOS can damage liver tissue and disrupt its function; however, the exact mechanisms remain unclear. In this study, we reviewed the adverse effects of PFOS on liver tissue and cells, as well as on liver function, to provide a reference for subsequent studies related to the toxicity of PFOS and liver injury caused by PFOS.

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Section: Effects Of Pfos On the Liver And Related Mechanisms Of Toxicitymentioning

confidence: 99%

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Wang

Liu

Yan

et al. 2022

Toxics

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“…Per-/polyfluorinated substance (PFAS) is a series of organic compounds containing at least one perfluorinated carbon atom, it is lipophobic and hydrophobic that are useful for manufacturing wide ranges of consumer products ( 24 , 25 ). PFASs have a stable chemical structure with a half-life of about 2–8 years, allowing them to persist and accumulate in the environment ( 10 , 26 ).…”

Section: Relationship Between Nafld and Edcsmentioning

confidence: 99%

Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease

Chen

Wang

Cui

et al. 2023

Front. Public Health

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Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder. With the improvement in human living standards, the prevalence of NAFLD has been increasing in recent years. Endocrine-disrupting chemicals (EDCs) are a class of exogenous chemicals that simulate the effects of hormones in the body. There has been growing evidence regarding the potential effects of EDCs on liver health, especially in NAFLD. This paper aims to summarize the major EDCs that contribute to the growing burden of NAFLD and to raise public awareness regarding the hazards posed by EDCs with the objective of reducing the incidence of NAFLD.

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“…Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are the two most common PFAS forms used and spread in the environment for decades . These types of PFASs have been widely detected in different parts of the environment and even in human blood. − Using solid adsorbents for PFAS removal, especially from water, is one of the most efficient, environmentally friendly, and economically feasible techniques that have been reported. ,− Carbonaceous materials, anion-exchange resins, porous organic and molecular imprinted polymers, minerals, and metal–organic frameworks (MOFs) are the reported adsorbents used for the removal of PFASs from water. ,,− Most of these materials exhibit large specific surface areas with suitable pore sizes and particular functional groups for the enhanced adsorption capacity of PFASs. However, these adsorbents suffer drawbacks such as slow adsorption rate, poor regeneration ability, and structural change at different pH levels.…”

Section: Introductionmentioning

confidence: 99%

Substitution and Orientation Effects on the Crystallinity and PFAS Adsorption of Olefin-Linked 2D COFs

Zarei,

Khosropour,

Khazdooz

et al. 2024

ACS Appl. Mater. Interfaces

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Solid phase adsorbents with high removal affinity for per-and polyfluoroalkyl substances (PFAS) in aqueous environments are sought. We report the synthesis and investigation of COF-I, a new covalent organic framework (COF) with a good affinity for PFAS adsorption. COF-I was synthesized by the condensation reaction between 2,4,6-trimethyl-1,3,5-triazine and 2,3-dimethoxyterephthaldehyde and fully characterized. In addition to the high crystallinity and surface area, COF-I showed high hydrolytic and thermal stability. Further, we converted its hydrophobic surface to a hydrophilic surface by converting the ortho-methoxy groups to hydroxyl derivatives and produced a new hydrophilic olefin-linked two-dimensional (2D) COF. We experimentally measured the crystallinity of both COFs by X-ray diffraction and used atomistic simulations coupled with cross-polarization/magic angle spinning solid-state nuclear magnetic resonance (CP/MAS ssNMR) to determine the relative amounts of AA-stacking and AB-stacking present. COF-I, with its hydrophobic surface and methoxy groups in the ortho positions, showed the best PFAS adsorption. COF-I reduced the concentration of perfluorooctanoic acid from 20 to 0.069 μg L −1 and to 0.052 μg L −1 for perfluorooctanesulfonic acid. These amounts are lower than the U.S. Environmental Protection Agency advisory level (0.070 μg L −1 ). High efficiency, fast kinetic adsorption, and reusability of COF-I are advantages of COF-I for PFAS removal from water.

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Per-/polyfluoroalkyl substance concentrations in human serum and their associations with liver cancer

Cited by 33 publications

References 60 publications

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Endocrine disrupting chemicals: A promoter of non-alcoholic fatty liver disease

Substitution and Orientation Effects on the Crystallinity and PFAS Adsorption of Olefin-Linked 2D COFs

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