Perbandingan Indeks Aterogenik Plasma Log (TG/HDL) pada Wanita Obes dan Non Obes

Abstract

Obesitas saat ini telah menjadi masalah kesehatan di dunia karena merupakan salah satu faktor bagi timbulnya penyakit seperti dislipidemia, stroke, penyakit jantung koroner dan lain-lain. Salah satu prediktor yang spesifik untuk menilai risiko terjadinya Penyakit Jantung Koroner (PJK) adalah dengan mengukur Indeks Aterogenik Plasma (IAP). IAP dihitung dengan menggunakan rumus Log(TG/HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara obesitas dengan profil High Density Lipoprotein (HDL), trigliserida (TG) dan IAP serta melihat risiko terjadinya PJK berdasarkan Indeks Aterogenik Plasma. Penelitian ini merupakan penelitian observasional dengan desain cross sectional. Subjek penelitian adalah wanita dewasa muda yang obes dan non obes dengan teknik pengambilan subjek menggunakan teknik purposive sampling. Hasil penelitian menunjukkan adanya hubungan antara lingkar perut dengan kadar TG, HDL dan IAP (p<0,05). Pada subjek obes terjadi peningkatan kadar TG, penurunan kadar HDL dan peningkatan nilai IAP. Dari hasil penelitian ini dapat disimpulkan bahwa berdasarkan nilai IAP subjek obes memiliki risiko PJK 4,472 kali lebih besar dibandingkan dengan subjek non obes. Kata Kunci : obesitas, trigliserida, high density lipoprotein, indeks aterogenik plasma ABSTRACTObesity is a health problem in the world because it can be a risk factor for other diseases such as dyslipidemia, stroke, coronary heart disease (CHD), and others. One of the specific CHD risk predictors is the Atherogenic Index of Plasma (AIP). AIP is calculated by using Log(TG/HDL). The purpose of this research is to investigate the relationship between obesity and HDL profile, TG and AIP, as well as to see the chance of having CHD based on AIP. This research was conducted using a descriptive observational method with a cross-sectional design. The subject of this research is the young women who are obese and not obese. The data collection method is a purposive sampling method. The result of this research showed that there is a relationship between abdominal circumference and triglycerides, HDL and AIP (p<0.05). Obese subjects have higher triglycerides, a decrease of HDL and an increase of AIP. From this result, it concludes that based on AIP, obese subjects tend to have CHD 4.472 times higher than non-obese subjects.

Atherogenic Index Profiles as Predictor of Cardiovascular Risk in Premenopausal and Menopausal Women

“…The atherogenic index value is one of the strongest markers of the risk of atherosclerosis and CHD compared to the results of the parameters of each lipid profile. Research by Niroumand et al (2015) and Kaniawati (2020) showed that the atherogenic Index of Plasma (AIP) was strongly associated with obesity (hip circumference and BMI) and physical activity (p<0,005). The atherogenic index value is not influenced by smoking habits, history of diabetes mellitus (DM), and hypertension (Edwards et al, 2017;K.…”

“…Niroumand et al (2015) in their research showed that plasma atherogenic index values had a significant correlation with abdominal circumference, BMI, and physical activity (p-value <0.05) on the incidence of CHD. The research by Kaniawati (2020) shows that there is a significant relationship between abdominal cirumference and LDL levels, triglycerides, and plasma atherogenic index (AIP).…”