Driven by the rapid development of big data, the amount of clinical data, including complex information, is expanding. Traditional data analysis methods cannot meet the need for mining data information, and artificial intelligence (AI) solves this problem. AI is increasingly being incorporated into modern medical practice. Algorithms provided by AI support advanced analysis and provide individualized aid to optimize medical decision-making. In plastic surgery, AI has made many breakthroughs in diagnosis, pre-operative surgical design, treatment decisions, and patient management. Plastic surgeons must recognize AI’s potential development and limitations. This review describes the current application of AI in plastic surgery and discusses the challenges and problems that need to be solved. This study aims to foster the application of this new AI technology in clinical practice.