From the merge of arts and crafts towards practice for mass production of desirability, consumption, and product development in a capitalist economy of scale, design has lost its natural ability of problem comprehension and tension alleviation. The modern world needs creativity, flexibility, and responsiveness embedded into design practices, mostly when a behavioural change, either individual or organisational, is intended. Still, the informality nature of the field is creating a gap between the study, research, and industrial design practice. Here, it is presented the Biology of Creativity Model (BoC), which is a design-by-analogy method that promotes an empowered design and creative practice through analysis of mostly biology reference texts for enhanced creative performance in a diverse array of contexts.