Background: Schizophrenia is a severe, chronic mental disorder that causes many psychosocial problems. In order to reveal these problems, it is necessary to measure the quality of life of people with schizophrenia. Aim: The aim of this meta-analysis is to compare the quality of life of people with schizophrenia and healthy subjects. Methods: Literature search was conducted in the Web of Science Core Collection database including the dates of January 2000 and March 2021. The systematic search provided 464 potentially relevant studies. The final sample consisted of 18 studies. Results: The results of using a random effects model for analysis indicated that schizophrenia subjects showed considerably lower quality of life scores compared to healthy controls. Conclusion: Determining the quality of people with schizophrenia will help us to create effective psychosocial intervention programs.