Percepción de los profesionales médicos respecto la adherencia terapéutica de los pacientes con osteoporosis

Abstract

Introduction: Adherence to oral treatment of patients with osteoporosis is low, with a high dropout rate in the first year. The most noteworthy result is the lack of therapeutic response. Objective: To ascertain the perception of physicians working with osteoporotic patients regarding adherence of these patients. Methods: Cross-sectional study conducted by opinion survey aimed at primary care physicians and specialists involved in osteoporosis treatment. Participants were selected by purposive sampling. Results: The questionnaire was answered by 235 specialists encompassing rheumatology (54.5%), orthopedics (10.6%) and primary care (18.7%). In 43.8% of participants, more than 25% of patients sometimes forget to take their treatment. According to 34.9%, more than 75% of patients are aware of treatment. Side effects and management complexity are the majority reasons that lead to a change in medication, mean value of 7.94±2.06 6±2.01 points respectively on a 0-10 scale. Conclusions: Overall, medical specialists attributed low adherence to side effects, polypharmacy and lack of communication between professionals. Dosage and space use of soluble dosage forms may be options to facilitate patient adherence to treatment with oral bisphosphonates. Improved education concerning the importance of the disease or increased patient monitoring could foster adherence.

Mechanistic advances in osteoporosis and anti‐osteoporosis therapies

“…Although a large number of drugs have been developed to prevent fractures, many patients still do not receive adequate treatment due to poor compliance and large side effects. 5 In this study, we divided anti-osteoporosis therapy into three categories: small molecular interventions, monoclonal antibodies, and synthetic peptides, according to the source, mode of action, and characteristics of drugs. Starting from the etiology and pathogenesis of primary osteoporosis, we systematically reviewed new therapeutic strategies or new clinical evidence on the basis of existing anti-osteoporosis therapies, hoping to endow readers with the mechanistical advances and clinical knowledge of osteoporosis.…”

“…Oral Bps has poor absorption and may cause low compliance due to gastrointestinal reactions. 5 Giving Bps intravenously bypasses the problem of gastrointestinal intolerance, but it will multiply the risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ). A high dosage of Bp is the main cause of BRONJ.…”

“…Classic anti‐osteoporosis therapies include anti‐resorptive and anabolic agents. Although a large number of drugs have been developed to prevent fractures, many patients still do not receive adequate treatment due to poor compliance and large side effects 5 . In this study, we divided anti‐osteoporosis therapy into three categories: small molecular interventions, monoclonal antibodies, and synthetic peptides, according to the source, mode of action, and characteristics of drugs.…”

Analysis of postmenopausal osteoporosis in primary care in the canary islands Spain (ESTOPMAPCA project)

“…An important problem in these patients with osteoporosis is the adherence to treatment with a high percentage of dropouts during the first year. The consecuenti Principio del formulariomost notable is the lack of therapeutic response [19].…”

El correcto cumplimiento del tratamiento para la osteoporosis: aún nos queda mucho por hacer

“…These results are corroborated by those obtained in other studies [19][20][21] . In this issue Blanch et al complete the perspective of non-compliance and poor adherence to treatment of osteoporosis from the physicians' point of view 22 . So far, most studies have analyzed the views of patients, that the degree of abandonment existed, the reasons and consequences, but the doctors' opinion regarding this matter had been rarely considered and is now published here.…”