Perception du glaucome et observance thérapeutique : une étude observationnelle multicentrique

Chiche, A.; Martin, G. Perez; Cenival, E. Brasnu de; Rousseau, Antoine; Giocanti, Audrey; Fel, Audrey; Kallel, Sofiene; Lombardi, Marco; Hamard, P.; Baudouin, Christophe; Labbé, Antoine

doi:10.1016/j.jfo.2017.01.009

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Во Франции проводилось многоцентровое обсервационное исследование, в рамках которого изучалось воспри-ятие глаукомы больными и их терапевтическая приверженность [38,39]. Основной причиной пропуска инстилляций была забывчивость (75 %), за которой следовала недоступность использования того или иного медикаментозного режима (37,5 %).…”

Section: Modern Multicenter Studies Of Psychological Features Proper unclassified

The psychology of a glaucoma patient

Габдрахманов¹,

Газизова

Селезнев³

et al. 2020

Rossijskij oftalʹmologičeskij žurnal

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Современные многоцентровые исследования психологических особенностей пациентов с глаукомой свидетельствуют о наличии физиологических и психологических проблем, связанных с этим заболеванием. Высокий уровень тревоги обуславливает клинически значимое повышение внутриглазного давления. Частота депрессии и тревоги у пожилых людей с нарушениями зрения в два раза выше, чем у пожилых людей в целом. Дефицит поля зрения оказывает более неблагоприятное влияние на качество жизни пациентов с глаукомой, чем даже ухудшение остроты зрения, особенно при локализации дефекта поля зрения в нижней полусфере. Несоблюдение назначенного гипотензивного режима может быть вызвано неверием пациентов в благополучный исход заболевания, низким уровнем доверия к врачу, низким уровнем образования и низким ежемесячным доходом пациента, наличием побочных эффектов местной гипотензивной терапии, типом применяемых препаратов и их количеством. Ключевые слова: первичная открытоугольная глаукома; депрессия; тревога; качество жизни Конфликт интересов: отсутствует. Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах.

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Section: Modern Multicenter Studies Of Psychological Features Proper unclassified

The psychology of a glaucoma patient

Габдрахманов¹,

Газизова

Селезнев³

et al. 2020

Rossijskij oftalʹmologičeskij žurnal

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“…The main challenge in glaucoma, as with other chronic conditions, is the adherence to treatment, which is partly correlated with local and systemic side effects [ 5 , 6 ]. Maintaining local tolerance is particularly challenging in patients with glaucoma, as the prevalence of ocular surface disorders is very high in this population [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The PRAMOS Study: PRostaglandin Analogues Monotherapy—Awareness Survey on Ocular Surface Involvement

Bastelica,

Renard,

Aptel

et al. 2024

Ophthalmol Ther

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Introduction Even though the local tolerance of prostaglandin (PG) analogues has improved drastically since the introduction of preservative-free (PF) eye drops, prescription patterns still vary widely among practitioners and between countries and could have an impact on the ocular surface of treated patients and, in consequence, their adherence. The aim of this study is to explore the prescribing patterns of PG analogues monotherapy in France and to evaluate their impact on ocular surface status. Methods This was a national multicenter cross-sectional observational study that was conducted by 18 glaucoma experts in France. Patients over 18 years of age and receiving monotherapy with topical PG analogues for the treatment of ocular hypertension and/or glaucoma, with no history of prior glaucoma surgery, were consecutively selected from the glaucoma outpatient clinics of participating physicians and underwent an ocular surface examination. Results A total of 344 eyes of 344 patients were enrolled between November 2022 and November 2023. Prescribed PG monotherapy was PF in 271 (78.7%) patients. Clinical history and ocular surface evaluation indicated that 79.4% of the study population ( n = 273) presented with at least one symptom or clinical sign of dry eye and that three patients out of four had an unstable tear film. Subgroup analysis comparing preserved and PF PG analogues showed a higher prevalence of conjunctival hyperemia and corneal staining in the preserved group. Multivariate analysis identified conjunctival hyperemia as consistently associated with preservative use (odds ratio = 7.654; p = 0.003 for moderate conjunctival hyperemia). Conclusions This study highlights the growing trend toward PF PG analogue prescriptions by specialists in France. However, ocular surface issues remain prevalent, impacting patient adherence and treatment efficacy. Comprehensive ocular surface examinations are crucial in glaucoma management to enhance long-term tolerance, compliance, and overall treatment success. Supplementary Information The online version contains supplementary material available at 10.1007/s40123-024-00936-9.

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“…Data collection is usually retrospective using a questionnaire, and is therefore associated to memory and subjectivity biases, and can thus be improved. [10][11][12] A study using an electronic drop counter found a poor compliance in 45% of glaucoma patients. 13 In order to explore objectively adherence to topical steroid after PK, we proposed to follow patients' treatment using a smart connected electronic device that counts the disposable single-dose units (SDU) eye drops.…”

Section: Introductionmentioning

confidence: 99%

Objective measurement of adherence to topical steroid medication after penetrating keratoplasty using an electronic monitoring aid: A pilot study

et al. 2022

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Objectives Corneal transplantation is the most common transplant worldwide and its success critically depends on the management of corneal graft rejection through topical steroid therapy during the first 12 months after surgery. There is currently no published data on adherence after keratoplasty. This pilot study aims to explore the adherence to topical steroid after penetrating keratoplasty using a smart electronic device. Methods Thirty patients undergoing penetrating keratoplasty were included to evaluate the adherence to topical dexamethasone medication for 12 months after surgery. Patients received the usual post-transplantation treatment (topical dexamethasone) and follow-up after surgery (day 15, months 1, 2, 3, 4, 5, 6, 9, and 12). Adherence to treatment was monitored using the KaliJAR device (Kali Care, Santa Clara, CA, USA), which recorded the number of single-dose units (SDU) discarded. At control visits, data recorded by the device were compared to the manually count of SDU. Adherence ratio and individual adherence curve were explored for all patients. Results Data from 27 patients showed a high agreement between adherence ratio calculated based on the device data and obtained from manual counting of the discarded SDU (intraclass coefficient correlation of 0.87 [95% CI: 0.738–0.938]). Mean adherence to the treatment over the 12-month study period was 95.2 ± 4%. Conclusions Adherence to topical dexamethasone for 12 months after corneal transplantation was high. The connected device was able to record accurately the discarded SDU. This approach would be a particular interest in the early identification and personalized follow-up of poorly adherent patients.

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Perception du glaucome et observance thérapeutique : une étude observationnelle multicentrique

Cited by 4 publications

References 23 publications

The psychology of a glaucoma patient

The psychology of a glaucoma patient

The PRAMOS Study: PRostaglandin Analogues Monotherapy—Awareness Survey on Ocular Surface Involvement

Objective measurement of adherence to topical steroid medication after penetrating keratoplasty using an electronic monitoring aid: A pilot study

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