Perchlorinated Triarylmethyl Radical 99% Enriched <sup>13</sup>C at the Central Carbon as EPR Spin Probe Highly Sensitive to Molecular Tumbling

Huffman, Justin L.; Poncelet, Martin; Moore, W. Michael; Eaton, Gareth R.; Driesschaert, Benoît

doi:10.1021/acs.jpcb.1c03778

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…4 X-band EPR spectra (Black) of 13 C 1 -OX071 (400 µM) in deoxygenated water with 0%, 12.5%, 25%, 35%, 45%, 67.5%, 80%, 85% and 90% (V/V) glycerol at 22 °C. The spectra were simulated (red dashed lines) using the chili function of EasySpin, using g = [2.0033, 2.0032, 2.0027] and A (MHz) = [18,18,160].…”

Section: Epr Characterization At X-bandmentioning

confidence: 99%

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Synthesis and characterization of a biocompatible ¹³C₁ isotopologue of trityl radical OX071 for in vivo EPR viscometry

Poncelet

Ngendahimana

Gluth

et al. 2022

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Section: Epr Characterization At X-bandmentioning

confidence: 99%

“…A perchlorinated trityl 99% 13 C 1 ( 13 C 1 -PTMTC) with slightly higher anisotropy (A ∥ − A ⊥ = 174 MHz, 62 G) was later reported. 18,19 Abnormal in vivo viscosity has been linked to many diseases, such as cancer. For example, a decrease of 1.1 cP has been reported in murine fibrosarcomas compared to normal tissue.…”

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confidence: 99%

Synthesis and characterization of a biocompatible ¹³C₁ isotopologue of trityl radical OX071 for in vivo EPR viscometry

Poncelet

Ngendahimana

Gluth

et al. 2022

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Molecular One‐ and Two‐Qubit Systems with Very Long Coherence Times

Schäfter,

Wischnat,

Tesi

et al. 2023

Advanced Materials

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General‐purpose quantum computation and quantum simulation require multi‐qubit architectures with precisely defined, robust interqubit interactions, coupled with local addressability. This is an unsolved challenge, primarily due to scalability issues. These issues often derive from poor control over interqubit interactions. Molecular systems are promising materials for the realization of large‐scale quantum architectures, due to their high degree of positionability and the possibility to precisely tailor interqubit interactions. The simplest quantum architecture is the two‐qubit system, with which quantum gate operations can be implemented. To be viable, a two‐qubit system must possess long coherence times, the interqubit interaction must be well defined and the two qubits must also be addressable individually within the same quantum manipulation sequence. Here results are presented on the investigation of the spin dynamics of chlorinated triphenylmethyl organic radicals, in particular the perchlorotriphenylmethyl (PTM) radical, a mono‐functionalized PTM, and a biradical PTM dimer. Extraordinarily long ensemble coherence times up to 148 µs are found at all temperatures below 100 K. Two‐qubit and, importantly, individual qubit addressability in the biradical system are demonstrated. These results underline the potential of molecular materials for the development of quantum architectures.

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A Novel Synthesis of Soluble, Stable Derivatives of the Perchlorinated Trityl Radical

Bushby

2024

Eur J Org Chem

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A new approach to the synthesis of derivatives of the perchlorinated tritryl radical is described. It relies on the fact that, under the conditions required to fully chlorinate the ortho positions of a triarylmethane, there is only minimal substitution of aryl fluorine by chlorine and then on the fact that, in the mixed Cl/F substituted triarylmethanes obtained, it is possible to selectively substitute the fluorine‐bearing positions using the sodium salt of n‐hexanol in n‐hexanol/dimethylsulfoxide. The meta‐hexyloxy derivatives obtained are much more soluble and photostable than the parent perchlorotrityl radical. For example, the introduction of four meta‐hexyloxy substituents gives a radical where, under white light illumination, the lifetime is improved by a factor of almost 104. The photostability of the radical, the lifetime of the excited state and the fluorescence all decrease as the number of meta‐hexyloxy substituents is increased. The improvements in solubility and in photostability observed should help in creating a more diverse range of perchlorotrityl radical derivatives and in the development of new applications.

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Perchlorinated Triarylmethyl Radical 99% Enriched ¹³C at the Central Carbon as EPR Spin Probe Highly Sensitive to Molecular Tumbling

Cited by 6 publications

References 34 publications

Synthesis and characterization of a biocompatible ¹³C₁ isotopologue of trityl radical OX071 for in vivo EPR viscometry

Synthesis and characterization of a biocompatible ¹³C₁ isotopologue of trityl radical OX071 for in vivo EPR viscometry

Molecular One‐ and Two‐Qubit Systems with Very Long Coherence Times

A Novel Synthesis of Soluble, Stable Derivatives of the Perchlorinated Trityl Radical

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Perchlorinated Triarylmethyl Radical 99% Enriched 13C at the Central Carbon as EPR Spin Probe Highly Sensitive to Molecular Tumbling

Cited by 6 publications

References 34 publications

Synthesis and characterization of a biocompatible 13C1 isotopologue of trityl radical OX071 for in vivo EPR viscometry

Synthesis and characterization of a biocompatible 13C1 isotopologue of trityl radical OX071 for in vivo EPR viscometry

Molecular One‐ and Two‐Qubit Systems with Very Long Coherence Times

A Novel Synthesis of Soluble, Stable Derivatives of the Perchlorinated Trityl Radical

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Perchlorinated Triarylmethyl Radical 99% Enriched ¹³C at the Central Carbon as EPR Spin Probe Highly Sensitive to Molecular Tumbling

Synthesis and characterization of a biocompatible ¹³C₁ isotopologue of trityl radical OX071 for in vivo EPR viscometry

Synthesis and characterization of a biocompatible ¹³C₁ isotopologue of trityl radical OX071 for in vivo EPR viscometry