Percutaneous Collagen Induction Versus Full-Concentration Trichloroacetic Acid in the Treatment of Atrophic Acne Scars

Leheta, Tahra M; Tawdy, Amira El; Hay, Rania Abdel; Farid, Sally

doi:10.1111/j.1524-4725.2010.01854.x

Cited by 61 publications

(70 citation statements)

References 12 publications

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“…This is similar to that observed in the study conducted by Leheta et al which also compared the two techniques among Egyptian patients. 7 In an Indian study conducted by Neerja, there was improvement with both the technique and there was no statistically significant difference in results between the two techniques. 8 But this study reported overall patient satisfaction with TCA CROSS.…”

Section: Discussionmentioning

confidence: 92%

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Dhollan

Thirunavukkarasu

2017

Int J Res Dermatol

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Background: Acne scars are a cause of major psychological morbidity in the young population. Microneedling using dermarollers which uses the principle of percutaneous collagen induction and Chemical reconstruction of skin scars (CROSS) using Trichloroacetic acid (TCA) are both widely used methods for the treatment of acne scars and are cheaper alternatives to LASER resurfacing. The aim of our study is to objectively compare the efficacy of microneedling using dermaroller with CROSS using 100% TCA in the management of acne scars.Methods: 30 patients with acne scars were divided into 2 groups A and B with 15 patients each. Group ‘A’ underwent microneedling using 1.5 mm dermaroller and Group ‘B’ underwent CROSS technique with 100% TCA. A total of 4 sessions at monthly intervals were performed on both groups. The percentage improvement in the acne scar grade between the two groups was compared using the student ‘t’ test.Results: Among the 30 patients, 13 (86%) patients in Group A (Microneedling) and 11 (78%) patients in group B (CROSS) noted significant reduction in their acne scar grade. The difference between the 2 groups was statistically insignificant. 3 patients had significant post inflammatory hyperpigmentation in group ‘B’.Conclusions: The techniques of microneedling and CROSS are both effective in acne scars But microneedling scores in other aspects such as faster wound healing, better skin rejuvenation and safety in dark skinned individuals.

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Section: Discussionmentioning

confidence: 92%

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Dhollan

Thirunavukkarasu

2017

Int J Res Dermatol

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“…Marked improvement ≥ 75% There was a statistically significant difference (P = 0.014) in an independent observer's after-treatment assessment between the groups according to a quartile grading scale [15] , which was used to evaluate the effectiveness of the therapies, as shown in Table 1 and In Group B, 7 patients (46.7%) ranked their improvement as marked, 5 patients (33.3%) as moderate improvement and 2 patients (13.3%) as significant and only 1 patient (6.7%) as slight improvement. There was a statistically significant difference (P = 0.038) in the patients' assessment score at the end of the treatment between the groups, as shown in Table 2 and Figure 2.…”

Section: Methodsmentioning

confidence: 90%

“…After centrifugation, the platelets and other vital growth proteins would be ready at the top of supernatant. The PRP was then drawn off, and the addition of calcium gluconate activated the PRP and resulted in the prompt release of 70% of growth factors from the α-granules within 10 minutes (and nearly all the contents within an hour).We used a quartile grading scale [15] to evaluate the effectiveness of the therapies, as stated below:…”

Section: Methodsmentioning

confidence: 99%

Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars

2017

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Among wound-healing modalities, platelet-rich plasma (PRP) has been used for wound healing, through the release of multiple growth factors. The platelets mediate wound healing by initiating the clotting pathway and the subsequent matrix remodelisation. The aim of the work was to study the role of injection of platelet-rich plasma in the treatment of scars. This study was conducted on thirty patients who were divided into two groups (A and B). Each group included fifteen patients. The two groups were randomly distributed by using individual sealed envelopes. Group A was subjected to subcision of their acne scars using Nokor needle, followed by suction. Group B patients were subjected to the same treatment but followed by an injection of platelet-rich plasma once per month over three months. In Group A, 6 patients (40%) showed moderate improvement, 5 patients (33.3%) showed slight improvement and 4 patients (26.7%) showed significant improvement. In Group B, 7 patients (46.7%) showed moderate improvement, 5 patients (33.3%) showed marked improvement and 3 patients (20%) showed significant improvement. There was a statistically significant difference on the independent observer's after-treatment assessment between the groups (P = 0.014). In conclusion, subcision suction leads to a persistent improvement of acne scars in a short time, and the coupling with injection of PRP is the most effective in the treatment of depressed facial scars.Keywords: Platelet-rich plasma; scars; subcision; suction Citation: Abou Khedr NAE, Hussein TM, Abd El-Fatah AME. Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars. J Surg Dermatol 2017; 2(2): 88-97; http://dx

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“…26,28 With this technique, the rolling is usually con nued un l bruising occurs, which ini ates the complex cascade of growth factors that fi nally results in collagen produc on [28][29][30] . Also it provides a clear channel for topical agents to be absorbed more eff ec vely through the top layer of skin.…”

Section: Discussionmentioning

confidence: 99%

“…30 The op mal scars to treat with skin needling are the rolling acne scars and superfi cial boxcar scars. 26,29 This technique has many advantages: 1. It is safe in all skin types and carry the lowest risk of pos nfl ammatory hyperpigmenta on when compared to laser resurfacing, chemical peels, or dermabrasion.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Efficacy of Skin Needling and Platelet Rich Plasma in the Treatment of Acne Scars

Ranjan¹,

Rs²,

Gupta³

2017

Nepal J Dermatol Venereol & Leprol

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Introduction: Permanent scars are the major complications of acne. Correction of scars is the priority for acne patients. Platelet-rich plasma (PRP) may be useful in the treatment of atrophic acne scars by promoting collagen deposition. Skin needling also releases growth factors, initiate a cascade of wound healing resulting in collagen production. Hence, skin needling and PRP should act synergistically to improve acne scars.

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Percutaneous Collagen Induction Versus Full-Concentration Trichloroacetic Acid in the Treatment of Atrophic Acne Scars

Abstract: PCI and 100% TCA CROSS were effective in the treatment of atrophic acne scars.

Cited by 61 publications

References 12 publications

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars

A Study of the Efficacy of Skin Needling and Platelet Rich Plasma in the Treatment of Acne Scars

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