Percutaneous core needle biopsy in the diagnosis of lung lesions

Abstract

Context: Percutaneous needle biopsy of lung (PCNBL) is advantageous over bronchoscopic biopsies to obtain adequate sample for peripheral lung lesions. Objective: The objective was to evaluate the diagnostic yield of image-guided PCNBL in the diagnosis of lung lesions and to classify lung carcinomas as per the recently proposed International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society/European Respiratory Society classification for small biopsies modified and adopted by the World Health Organization, 2015. Materials and Methods: A total of 280 image-guided PCNBL were analyzed. The radiological findings and routine hematoxylin and eosin (H&E)-stained sections along with immunohistochemistry (IHC) were analyzed in all the cases. Molecular testing was done depending on tissue diagnosis and availability. Results: Majority (81%) were diagnosed as malignant lesions, with adenocarcinoma (ADC) being the most common. More than 70% were diagnosed on H&E morphology alone, with thirty cases requiring IHC to categorize as ADC. Nearly 60% were categorized as squamous cell carcinoma on morphology alone and the rest required IHC. Though TTF1 showed higher sensitivity than napsin A, the latter is more specific. Both p63 and p40 were found to be highly sensitive for squamous cell carcinoma, but p40 was more specific than p63. Epidermal growth factor receptor could be evaluated on 94.4% of ADC samples, indicating good yield for molecular testing. Conclusion: PCNBL yields adequate sampling for tissue diagnosis and ancillary testing with minimal complications. The use of IHC markers reduces the number of non-small-cell not otherwise specified cases significantly.

COVID-19 in Egypt after a year: the first and second pandemic waves from the radiological point of view; multi-center comparative study on 2000 patients

“…Spagnolo P et al [ 38 ] and Tale S et al [ 39 ] alarmed also to the bad prognosis of post-COVID fibrosis. Udwadia ZF et al [ 40 ] dramatically described it as the tsunami that follows the earthquake.…”

Decrease in life expectancy due to COVID-19 disease not offset by reduced environmental impacts associated with lockdowns in Italy

“…In this regard, it is worth remarking that long-term damages of SARS-CoV2 in organs and systems, such as lung fibrosis ( Udwadia et al, 2021 ) and neuropsychiatric disturbances ( Willi et al, 2021 ), have been extensively hypothesized and evidenced also in young patients ( Willi et al, 2021 ), but they are far from being fully defined in terms of pathogenesis and epidemiology. The exact comprehension of the mechanisms leading to chronic diseases, such as pulmonary fibrosis and end-stage renal disease, as well as their incidence in patients previously affected by COVID-19, will be key in determining how DALYs relate to this condition.…”