Percutaneous metals absorption following exposure to road dust powder

Magnano, Greta Camilla; Marussi, Giovanna; Pavoni, Elena; Adami, Gianpiero; Filon, Francesca Larese; Crosera, Matteo

doi:10.1016/j.envpol.2021.118353

Cited by 18 publications

(14 citation statements)

References 52 publications

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“…The oral reference dose (RfD) is assumed as the threshold value (obtained from US EPA) [55]. The metal values were in line with those found in men exposed to road dust and high pollutants levels [59,60]. The test of the CDI average values calculated for each metal and the p-value obtained by the Poisson correlation were significantly different from zero.…”

Section: Pollutants Adsorptionmentioning

confidence: 76%

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

et al. 2022

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Air pollution is a problem shared by the entire world population, and researchers have highlighted its adverse effects on human health in recent years. The object of this paper was the relationship between the pollutants’ concentrations measured in the air and the quantity of pollutant itself inhaled by the human body. The area chosen for the study has a high environmental impact given the significant presence on the territory of polluting activities. The Acerra area (HI) has a waste-to-energy plant and numerous industries to which polluting emissions are attributed. This area has always been the subject of study as the numbers of cancer patients are high. A survey on male patients to evaluate the heavy metals concentrations in the blood was conducted in the two areas and then linked to its values aero-dispersed. Using the air quality data measured by the monitoring networks in two zones, one with high environmental impact (HI) and one with low environmental impact (LI), the chronicle daily intake (CDI) of pollutants inhaled by a single person was calculated. The pollutants considered in this study are PM10 and four heavy metals (As, Cd, Ni, Pb) constituting the typical particulates of the areas concerned. The CDI values calculated for the two zones are significantly higher in the HI zone following the seasonal pollution trend.

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Section: Pollutants Adsorptionmentioning

confidence: 76%

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

et al. 2022

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“…The thickness of pig-ear skin was measured with a micrometer caliper (Mitutoyo, Roissy en France, France) as <0.90 ± 0.02 mm. To evaluate skin integrity, trans epidermal water loss (TEWL) was measured on each skin piece after 1 h of equilibration using a Vapometer (Delfin Technologies, Kuopio, Sweden), already used previously [ 27 ]. The average TEWL values of skin samples was below 10 g m −2 h −1 [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity

et al. 2022

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Cyclodipeptides (CDPs) or diketopiperazines (DKPs) are often found in nature and in foodstuff and beverages and have attracted great interest for their bioactivities, biocompatibility, and biodegradability. In the laboratory, they can be prepared by green procedures, such as microwave-assisted cyclization of linear dipeptides in water, as performed in this study. In particular, five CDPs were prepared and characterized by a variety of methods, including NMR and ESI-MS spectroscopies and single-crystal X-ray diffraction (XRD), and their cytocompatibility and anti-aging activity was tested in vitro, as well as their ability to penetrate the different layers of the skin. Although their mechanism of action remains to be elucidated, this proof-of-concept study lays the basis for their future use in anti-age cosmetic applications.

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“…In vitro permeation and distribution in skin layers after 24 h exposure Skin absorption studies were performed in static diffusion cells according to the OECD guidelines [45]. The protocol for testing the skin permeation of Ni after exposure to Ni powder was derived from our previous works [22,23]. The skin pieces were mounted between the donor and receptor chambers of Franz-type static diffusion cells, with the stratum corneum facing the donor chamber.…”

Section: Human Skin Membranesmentioning

confidence: 99%

“…Notably, the ionized metal represents the Ni content able to permeate through the skin [21]. Recently, the study of Magnano et al [22] showed that a higher content of Ni ions permeated through the intact skin compared to other metal ions following exposure to road dust containing multiple metals at a relatively low dose, representing a potential health hazard. Similarly, it was demonstrated that NiNPs dissolved in artificial sweat could produce ions that may penetrate through the skin, directly causing an immune response [12].…”

Section: Introductionmentioning

confidence: 99%

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

Magnano

Marussi

Crosera

et al. 2023

Intern J of Cosmetic Sci

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ObjectiveBarrier creams (BCs) are marketed as locally‐applied medical devices or cosmetic products to protect the skin from exposure to chemicals and irritants. Generally, the mechanism of action of such products is mainly due to the formation of a superficial thin film between the skin and the irritant or sensitizer, thus reducing or totally blocking the cutaneous penetration of such agents. Specifically, studies focusing on the effectiveness of commercial protective creams to prevent nickel cutaneous penetration are extremely scarce. The aim of the current work, therefore, is to evaluate the protective role of a commercially available barrier cream for nickel and compare the results with a simple moisturizing, following exposure to Ni powder.MethodsMarketed BCs were evaluated and tested. Human skin absorption of Ni was studied in vitro using static Franz diffusion cells.ResultsOur results demonstrate that the application of both formulations caused a reduction of Ni inside the skin (8.00 ± 3.35 μg·cm‐2 for the barrier cream and 22.6 ± 12.6 μg·cm‐2 for the general moisturizing product), with the specialized barrier cream being statistically (p = 0.015) more efficient on forming a protective barrier, thus evidencing the importance of some ingredients of such formulations on the nickel dermal accumulation.ConclusionsThe composition of the formulations based on film forming or chelating agents may play an imperative role to reduce the cutaneous penetration of Ni.

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Percutaneous metals absorption following exposure to road dust powder

Cited by 18 publications

References 52 publications

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity

Probing the effectiveness of barrier creams against human skin penetration of nickel powder

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