Percutaneous Nephrolithotomy in Children with Cystine Stone: Long-Term Outcomes from a Single Institution

Önal, Bülent; Doğan, Cem; Çitgez, Sinharib; Argun, Burak; Önder, Ali Ulvi; Sever, Lale; Çalışkan, Salim; Canpolat, Nur; Taşdemir, Mehmet; Erözenci, Ahmet

doi:10.1016/j.juro.2013.01.016

Cited by 18 publications

(23 citation statements)

References 26 publications

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“…In selected cases, especially if early diagnosis is possible, minimally invasive procedures allow excellent outcomes, improving patient quality of life while reducing morbidity. In another study evaluating 65RU in 51 children with large cystine stones (mean burden of 3.3cm 2 ) treated with PCNL, the stone free rate was 63.1% (41/65RUs) ( 15 ). After additional endoscopic procedures the final stone-free rate was increased to 73.8%.…”

Section: Discussionmentioning

confidence: 99%

The challenge of cystine and struvite stone formers: clinical, metabolic and surgical assessment

et al. 2016

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Purpose:To compare the clinical, metabolic, and calculi characteristics of cystine and struvite stone patients after percutaneous nephrolithotripsy (PCNL).Material and Methods:Between January/2006-July/2013, 11 cystine stone patients were treated in our clinic. Of those, 3 were excluded due to incomplete follow-up. Eight cystine stone patients (2 with bilateral disease; 10 renal units-RU) were considered for further analysis. A cohort of 8 struvite stone formers (10RU) was matched having the same age, gender, body mass index (BMI) and Guys stone score. Analyzed parameters comprised demographic data, serum/urinary metabolic evaluation and surgical outcomes.Results:Both groups had 6 female patients. Groups were similar in regards to age, gender, BMI, stone burden, and serum creatinine (p=NS). All patients had PCNL as the first surgical treatment modality. Stone free rate (SFR) after the first PCNL tended to be lower (0%) in the cystine compared to the struvite group (40%)(p=0.08). Final SFR after secondary procedures increased to 70% in cystine and 80% in struvite patients (p=1.0); mean number of procedures to achieve stone free status was higher in the first group (3.57 vs. 2.0;p=0.028). Hypocitraturia was found in all patients, but struvite cases presented with lower mean urinary citrate levels (p=0.016). Other common abnormalities were elevated urinary pH (cystine 75% and struvite 62.5%;p=1.0) and low urinary volume (62.5%,37.5%;p=0.63).Conclusion:Multiple interventions and suboptimal stone free rates are trait of the significant stone burden of struvite and cystine patients. Underlying metabolic abnormalities characterized by increased urinary pH, hypocitraturia and low urinary volume are often encountered in both populations.

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Section: Discussionmentioning

confidence: 99%

The challenge of cystine and struvite stone formers: clinical, metabolic and surgical assessment

et al. 2016

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“…Although shock wave lithotripsy is a safe procedure, however Shokeirs and their colleagues showed percutaneous nephrolithotomy is better than shock wave lithotripsy for treatment of 1 to 2 cm renal stones in children, yielding higher stone-free and lower re-treatment rates [11]. More ever Onal et al revealed the safety and efficacy of PCNL in pediatric patients with cystine stones resistance to SWL [12].…”

Section: Discussionmentioning

confidence: 99%

Our Experience with Totally Ultrasonography-Guided Percutaneous Nephrolithotomy in Children

SharifiaghdasFarzaneh

Tabibi

NouralizadehAkbar

et al. 2021

Journal of Endourology

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“…One previous study reported a complication rate associated with PCNL in patients with cystine stones of 15.4% [14]. Another study reported an overall complication rate of 23.8% for URS [15].…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported an overall success rate of PCNL in children with cystine stones of 63.1% [14]. Another previous study reported a success rate of 71% in patients with cystine stones who underwent URS [15].…”

Section: Discussionmentioning

confidence: 99%

Multimodal Treatments of Cystine Stones: An Observational, Retrospective Single-Center Analysis of 14 Cases

Shim

Park

2014

Korean J Urol

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PurposeTo document the experiences of a single institution in evaluating the clinical courses and treatment outcomes of patients with cystine stones.Materials and MethodsThe clinical data of 14 patients with cystine stones who were treated at our institution from March 1994 to July 2012 were reviewed. These data included age at first visit, gender, family history, body mass index, presence of a single kidney, stone locations, stone burden, routine urinalysis, and culture. In addition, we also analyzed data on surgery, shock wave lithotripsy, medical treatment, stone recurrence or regrowth, and overall treatment success rates.ResultsThe mean age of our patients at their first visit was 19.6±5.0 years, and eight patients were males. The median stone burden and mean urine pH before each surgery were 6.5 cm2 and 6.5±0.9, respectively. Two patients had a family history of cystine stones. Patients underwent surgery an average of 2.7 times. The median interval between surgeries was 27.3 months, and 1 open surgery, 12 percutaneous nephrolithotomies, and 25 ureterorenoscopies were performed. Potassium citrate or sodium bicarbonate was used in nine cases. D-Penicillamine was continuously used in three patients. Patients had an average incidence of 3.2 recurrences or regrowth of stones during the median follow-up period of 60.5 months.ConclusionsPatients with cystine stones have high recurrence or regrowth rates and relatively large stone burdens. Adequate treatment schedules must therefore be established in these cases to prevent possible deterioration of renal function.

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Percutaneous Nephrolithotomy in Children with Cystine Stone: Long-Term Outcomes from a Single Institution

Cited by 18 publications

References 26 publications

The challenge of cystine and struvite stone formers: clinical, metabolic and surgical assessment

The challenge of cystine and struvite stone formers: clinical, metabolic and surgical assessment

Our Experience with Totally Ultrasonography-Guided Percutaneous Nephrolithotomy in Children

Multimodal Treatments of Cystine Stones: An Observational, Retrospective Single-Center Analysis of 14 Cases

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