Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis

Pluut, Olivier A.; Bianco, Carlotta; Jakaša, Ivone; Visser, Maaike; Krystek, Petra; Filon, Francesca Larese; Rustemeyer, Thomas; Kežić, Sanja

doi:10.1016/j.toxlet.2015.03.014

Cited by 21 publications

(29 citation statements)

References 19 publications

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“…The aggregation of silver in the SC might explain the low penetration of silver that we previously found both in our parallel in vitro and in vivo studies with the same textile (Bianco et al, 2015; Pluut et al, 2015). This is also consistent with a study of George et al (2014), which reported low serum and urinary levels of silver after topical application of a nanosilver textile (10–40 nm) although silver NPs have been found below epidermis (George et al, 2014).…”

Section: Discussionmentioning

confidence: 54%

“…soluble and insoluble) in 20 AD patients and 20 healthy subjects (Pluut et al, 2015). In a number of subjects, next to dermal uptake we characterized the silver particles in the SC, which is described in this paper.…”

Section: Discussionmentioning

confidence: 99%

“…The tapes were stored separately in cryo vials at 4 °C prior to analysis by SEM and AFM. The concentration of silver on the tapes was determined as describe previously in Pluut et al (2015). Briefly, 1 mL MilliQ water and 0.5 mL of ultrapure HNO 3 (69%) was added to the tape.…”

Section: Methodsmentioning

confidence: 99%

“…An impaired skin barrier will not only increase the amount of a compound that penetrate across the skin but will possibly also allow for penetration of particles that normally would not be able to penetrate due to their large size (Kezic & Nielsen, 2009). This study is a part of a larger previously published investigation (Pluut et al, 2015) in which percutaneous penetration of total silver (i.e. ionic and particulate form) has been investigated in 20 healthy volunteers and 20 AD patients.…”

Section: Introductionmentioning

confidence: 99%

“…ionic and particulate form) has been investigated in 20 healthy volunteers and 20 AD patients. From the cohort of patients described in Pluut et al (2015), tape strips from seven AD and seven healthy subjects after the fifth day of exposure were randomly chosen and further investigated for the presence of silver particles in the skin by using more advanced techniques, atomic force microscopy (AFM) and scanning electron microscopy with energy dispersive X-ray analysis (SEM-EDX), than were used in Pluut et al (2015).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of silver particles in the stratum corneum of healthy subjects and atopic dermatitis patients dermally exposed to a silver-containing garment

et al. 2016

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Silver is increasingly being used in garments to exploit its antibacterial properties. Information on the presence of silver nanoparticles (AgNPs) in garments and their in vivo penetration across healthy and impaired skin from use is limited. We investigated the presence of AgNPs in a silver containing garment and in the stratum corneum (SC) of healthy subjects (CTRLs) and individuals with atopic dermatitis (AD). Seven CTRLs and seven AD patients wore a silver sleeve (13% Ag w/w) 8 h/day for five days on a forearm and a placebo sleeve on the other forearm. After five days, the layers of the SC were collected by adhesive tapes. The silver particles in the garment and SC were characterized by scanning electron microscopy with energy dispersive X-ray analysis (SEM-EDX) and atomic force microscopy (AFM). AFM and SEM revealed the presence of sub-micrometre particles having a broad range of sizes (30–500 nm) on the surface of the garment that were identified as silver. On the SC tapes collected from different depths, aggregates with a wide range of sizes (150 nm−2 μm) and morphologies were found. Most aggregates contained primarily silver, although some also contained chlorine and sulfur. There was no clear difference in the number or size of the aggregates observed in SC between healthy and AD subjects. After use, AgNPs and their aggregates were present in the SC at different depths of both healthy subjects and AD patients. Their micrometre size suggests that aggregation likely occurred in the SC.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of silver particles in the stratum corneum of healthy subjects and atopic dermatitis patients dermally exposed to a silver-containing garment

et al. 2016

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Nanomedicine in Dermatology: Nanotechnology in Prevention, Diagnosis, and Therapy

Hofmeier

Surber

2016

Nanoscience and Nanotechnology for Human Health

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Some Other Metals

Julander¹,

Lidén²

2018

Kanerva’s Occupational Dermatology

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Several metals such as aluminum, beryllium, copper, gold, mercury, palladium, platinum, and rhodium are able to cause skin sensitization, allergic contact dermatitis, and other skin effects. Pure metals, alloys, and metal compounds have different abilities to cause sensitization and dermatitis. Furthermore many of the metals and their compounds are also known to cause systemic toxicity and cancer. The clinical relevance of patch test reactivity to some of these metals is not known. The prevalence of contact allergy in occupationally exposed groups, consumers, or dermatitis patients is also not known for all of these metals.

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Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis

Cited by 21 publications

References 19 publications

Characterization of silver particles in the stratum corneum of healthy subjects and atopic dermatitis patients dermally exposed to a silver-containing garment

Characterization of silver particles in the stratum corneum of healthy subjects and atopic dermatitis patients dermally exposed to a silver-containing garment

Nanomedicine in Dermatology: Nanotechnology in Prevention, Diagnosis, and Therapy

Some Other Metals

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