Percutaneous radiofrequency ablation (RFA) or robotic radiosurgery (RRS) for salvage treatment of colorectal liver metastases

Stintzing, Sebastian; Grothe, Alexander; Hendrich, Saskia; Hoffmann, Ralf‐Thorsten; Heinemann, Volker; Rentsch, Markus; Fuerweger, Christoph; Muacevic, Alexander; Trumm, C.

doi:10.3109/0284186x.2013.766362

Cited by 53 publications

(36 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an attempt to compare RFA with SBRT, Stintzing and colleagues evaluated the outcomes of these two treatments in a single institution retrospective study. 27 The cohort included 60 heavily treated colorectal cancer patients. Median SBRT dose was 24-26 Gy at the 80% isodose.…”

Section: Discussionmentioning

confidence: 99%

Institutional experience in the treatment of colorectal liver metastases with stereotactic body radiation therapy

Romero

Keskin-Cambay

et al. 2017

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

Metastases LiverStereotactic body radiation therapy a b s t r a c t Aim: To investigate whether the impact of dose escalation in our patient population represented an improvement in local control without increasing treatment related toxicity. Materials and methods:A cohort of consecutive patients with colorectal liver metastases treated with stereotactic body radiation therapy (SBRT) between December 2002 and December 2013 were eligible for this study. Inclusion criteria were a Karnofsky performance status ≥80% and, according to the multidisciplinary tumor board, ineligibility for surgery or radiofrequency ablation. Exclusion criteria were a lesion size >6 cm, more than 3 metastases, and treatment delivered with other fractionation scheme than 3 times 12.5 Gy or 16.75 Gy prescribed at the 65-67% isodose. To analyze local control, CT or MRI scans were acquired during follow-up. Toxicity was scored using the Common Toxicity Criteria Adverse Events v4.0.Results: A total of 40 patients with 55 colorectal liver metastases were included in this study.We delivered 37.5 Gy to 32 lesions, and 50.25 Gy to 23 lesions. Median follow-up was 26 and 25 months for these two groups. Local control at 2 and 3 years was 74 and 66% in the low dose group while 90 and 81% was reached in the high dose group. No significant difference in local control between the two dose fractionation schemes could be found. Grade 3 toxicity was limited and was not increased in the high dose group.Conclusions: SBRT for colorectal liver metastases offers a high chance of local control at long term. High irradiation doses may contribute to enhance this effect without increasing toxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

Institutional experience in the treatment of colorectal liver metastases with stereotactic body radiation therapy

Romero

Keskin-Cambay

et al. 2017

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

“…40 In comparison to other ablative techniques such as RFA, MWA produces consistently higher intertumoural temperatures, larger tumour ablation volumes, faster ablation times and less procedural pain. 39 Moreover, the heat sink effect of MWA is minimal and usually does not create ablation zone distortions in the vicinity of large blood vessels (Figure 1). 39 Most studies reported MWA to be a relatively safe method with low complication rates.…”

Section: Microwave Ablationmentioning

confidence: 99%

“…39 Moreover, the heat sink effect of MWA is minimal and usually does not create ablation zone distortions in the vicinity of large blood vessels (Figure 1). 39 Most studies reported MWA to be a relatively safe method with low complication rates. The most common complications of MWA are pain, fever, ascites, bile duct injury and pleural effusion (Table 4).…”

Section: Microwave Ablationmentioning

confidence: 99%

“…Owing to the convection profile, MWA is suitable for treatment of larger metastases with tumour diameter #6 cm, such as liver metastases of colorectal carcinoma. 39 Percutaneous MWA is usually performed under ultrasound or CT guidance. 40 In comparison to other ablative techniques such as RFA, MWA produces consistently higher intertumoural temperatures, larger tumour ablation volumes, faster ablation times and less procedural pain.…”

Section: Microwave Ablationmentioning

confidence: 99%

See 1 more Smart Citation

Current strategies in interventional oncology of colorectal liver metastases

Gruber‐Rouh

Marko

Thalhammer

et al. 2016

BJR

View full text Add to dashboard Cite

The adequate treatment of non-resectable liver metastases from colorectal cancer which are resistant to systemic chemotherapy currently provides a great challenge. The aim is to identify and review key strategies in the treatment of colorectal liver metastases. A search for current literature on the topic of interventional strategies for colorectal metastases was performed in Medline in order to achieve this goal. Studies before 2005 and with ,20 patients treated for colorectal metastases were excluded. Transarterial chemoembolization (TACE), transarterial embolization and selective internal radiation therapy (SIRT) were identified as examples of regional strategies for colorectal liver metastases, utilizing the unique blood supply of the liver. Radiofrequency ablation (RFA), microwave ablation (MWA) and cryoablation were selected as examples for currently available ablative techniques. Median survival in the key studies reviewed ranged from 7.7 to 28.6 for TACE, 8.3-12.6 for SIRT, 8.2-53.2 for RFA and 29-43 months for MWA. After review of the literature, it can be concluded that interventional oncologic therapies are a safe and effective method for treating colorectal liver metastases. The use of new chemotherapeutic agents for local therapy and new ablation technologies and techniques may increase patient survival and allows a neoadjuvant therapy setting. In addition, a combination of local therapies may be used to increase effectiveness in the future, which is subject to further research. INTRODUCTIONColorectal cancer is one of the most common cancers that shows fatal progression.1 Colorectal carcinoma most commonly metastasises to the liver due to haematogenous spread.2 At the time of diagnosis, 20-30% of patients have liver metastases, and during the course of disease, up to 60% of patients develop hepatic metastases.3 Although surgical excision is the first-line treatment for colorectal metastases, only 10-25% of patients are candidates for surgical resection. 4 Neoadjuvant systemic chemotherapy only allows 10-30% of patients with unresectable colorectal liver metastases sufficient downsizing for resection.

show abstract

“…However, with growing experience, it proves to be a valuable contribution to the treatment armamentarium of CRLM. One study compared stereotactic radiotherapy to RFA in a matched patient population and found a significantly longer local disease free survival than in the patients treated with RFA [40,41]. These findings should be confirmed by larger prospective trials.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Ablative Radiotherapy to Treat Colorectal Liver Metastases: Ready for Prime-Time?

Nielsen¹

2016

J Liver

View full text Add to dashboard Cite

show abstract

Percutaneous radiofrequency ablation (RFA) or robotic radiosurgery (RRS) for salvage treatment of colorectal liver metastases

Abstract: (2013) Percutaneous radiofrequency ablation (RFA) or robotic radiosurgery (RRS) for salvage treatment of colorectal liver metastases, Acta Oncologica, 52:5, 971-977,

Cited by 53 publications

References 33 publications

Institutional experience in the treatment of colorectal liver metastases with stereotactic body radiation therapy

Institutional experience in the treatment of colorectal liver metastases with stereotactic body radiation therapy

Current strategies in interventional oncology of colorectal liver metastases

Stereotactic Ablative Radiotherapy to Treat Colorectal Liver Metastases: Ready for Prime-Time?

Contact Info

Product

Resources

About