Percutaneous tumor ablation versus partial nephrectomy for small renal mass: the impact of histologic variant and tumor size

Bianchi, Lorenzo; Chessa, F.; Barbaresi, U.; Casablanca, Carlo; Piazza, Pietro; Mottaran, Angelo; Droghetti, Matteo; Roveroni, C.; Balestrazzi, Eleonora; Gentile, Giorgio; Gaudiano, Caterina; Bertaccini, Alessandro; Marcelli, Emanuela; Porreca, Angelo; Concilio, Bernardino De; Serra, Carla; Celia, Antonio; Brunocilla, Eugenio; Schiavina, Riccardo

doi:10.23736/s2724-6051.20.03983-1

Cited by 14 publications

(22 citation statements)

References 28 publications

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“…BSHS-A score was used to evaluate the quality of literature in this study, including general health status, social relations ( 21 ), psychological function and physical function. Use the evaluation tools and methods recommended by Cochrane manual to evaluate the risk of bias in the study.…”

Section: Resultsmentioning

confidence: 99%

RETRACTED: Meta analysis of clinical prognosis of radiofrequency ablation versus partial nephrectomy in the treatment of early renal cell carcinoma

Wang

2023

Front. Oncol.

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ObjectiveTo systematically review the differences between radiofrequency ablation and partial nephrectomy in patients with early-stage renal cell carcinoma, and to provide evidence-based medical evidence for the choice of surgery for patients with early-stage renal cell carcinoma.MethodsAccording to the search strategy recommended by the Cochrane Collaboration, Chinese databases such as CNKI, VIP Chinese Science and Technology Periodicals Database (VIP), and Wanfang Full-text Database were searched with Chinese search terms. And PubMed and MEDLINE as databases for English literature retrieval. Retrieve the relevant literature on renal cell carcinoma surgical methods published before May 2022, and further screen radiofrequency ablation and partial nephrectomy in patients with renal cell carcinoma The relevant literature on the application is analyzed. RevMan5.3 software was used for heterogeneity test and combined statistical analysis, sensitivity analysis, and subgroup analysis. Analysis, and draw forest plot, using Stata software Begger quantitative assessment of publication bias.ResultsA total of 11 articles were involved, including 2958 patients. According to the Jadad scale, 2 articles were of low quality, and the remaining 9 articles were of high quality. Results of this study demonstrates the advantages of radiofrequency ablation in early-stage renal cell carcinoma. The results of this meta-analysis showed that compared with partial nephrectomy, there was significant difference in the 5-year overall survival rate between radiofrequency ablation and partial nephrectomy and there was a statistically significant difference between the two surgical methods in the 5-year relapse free survival rate of early renal cell carcinoma.Conclusion1. Compared with partial nephrectomy, the 5-year relapse-free survival rate, the 5-year cancer specific survival rate and the overall 5-year survival rate were higher in the radiofrequency ablation group. 2. Compared with partial nephrectomy, there was no significant difference in the postoperative local tumor recurrence rate of radiofrequency ablation. 3. Compared with partial resection, radiofrequency ablation is more beneficial to patients with renal cell carcinoma.

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Section: Resultsmentioning

confidence: 99%

RETRACTED: Meta analysis of clinical prognosis of radiofrequency ablation versus partial nephrectomy in the treatment of early renal cell carcinoma

Wang

2023

Front. Oncol.

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“…Full-text reviews were performed for the remaining 95 articles. Ultimately, 81 papers were excluded (other than percutaneous cryoablation technique, single-arm studies, studies reporting no single outcome of interest or studies with overlapping cohorts), leaving 14 studies included in the present systematic review and meta-analysis [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…The available records were published from 2017 to 2023. Seven out of fourteen studies [ 14 , 15 , 16 , 17 , 18 , 21 , 22 ] presented data for European populations, followed by four [ 11 , 19 , 23 , 24 ] and three [ 12 , 13 , 20 ] papers conducted in Japan and the United States, respectively. The vast majority of studies had retrospective designs [ 11 , 12 , 13 , 14 , 15 , 17 , 19 , 20 , 22 , 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

Clinical and Oncological Outcomes Following Percutaneous Cryoablation vs. Partial Nephrectomy for Clinical T1 Renal Tumours: Systematic Review and Meta-Analysis

Nowak,

Janczak,

Łaszkiewicz

et al. 2024

Cancers

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Percutaneous cryoablation (PCA) can be an alternative to partial nephrectomy (PN) in selected patients with stage T1 renal tumours. Existing meta-analyses regarding ablative techniques compared both laparoscopic and PCA with PN. That is why we decided to perform a meta-analysis that focused solely on PCA. The aim of this study was to compare the complications and functional and oncological outcomes between PCA and PN. A systematic literature search was performed in January 2024. Data for dichotomous and continuous variables were expressed as pooled odds ratios (ORs) and mean differences (MDs), both with 95% confidence intervals (CIs). Effect measures for the local recurrence-free survival (LRFS), metastasis-free survival (MFS), cancer-specific survival (CSS) and overall survival (OS) were expressed as pooled hazard ratios with 95% CIs. Among 6487 patients included in the 14 selected papers, 1554 (23.9%) and 4924 (76.1%) underwent PCA and PN, respectively. Compared with the PN group, patients undergoing PCA had significantly lower overall and major postoperative complication rates. There was no difference in renal function between PCA and PN groups. When analysing collective data for cT1 renal carcinoma, PCA was associated with worse LRFS compared with PN. However, subgroup analysis revealed that in the case of PCA, LRFS was not decreased in patients with cT1a tumours. Moreover, patients undergoing robotic-assisted PN had improved LRFS compared with those undergoing PCA. No significant differences were observed between PCA and PN in terms of MFS and CSS. Finally, PCA was associated with worse OS than PN in both collective and subgroup analyses. In conclusion, PCA is associated with favourable postoperative complication rates relative to PN. Regarding LRFS, PCA is not worse than PN in cT1a tumours but has a substantially relevant disadvantage in cT1b tumours. Also, RAPN might be the only surgical modality that provides better LRFS than PCA. In cT1 tumours, PCA shows MFS and CSS comparable to PN. Lastly, PCA is associated with a shorter OS than PN.

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“…However, in the case of elderly patients or in severe comorbidity, active surveillance of the mass may be an alternative approach. The discrimination of RO from ccRCC by non-invasive radiomic methods would allow for better selection of patients for active surveillance of a renal mass (i.e., in the case of high suspicion of RO) or active treatment including novel percutaneous ablation as well as surgery (in the case of high suspicion of ccRCC) [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Radiomic ZOT Features in the Automated Discrimination of Oncocytoma from Clear Cell Renal Cancer

Carlini

Gaudiano

Golfieri

et al. 2023

JPM

Self Cite

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Background: Benign renal tumors, such as renal oncocytoma (RO), can be erroneously diagnosed as malignant renal cell carcinomas (RCC), because of their similar imaging features. Computer-aided systems leveraging radiomic features can be used to better discriminate benign renal tumors from the malignant ones. The purpose of this work was to build a machine learning model to distinguish RO from clear cell RCC (ccRCC). Method: We collected CT images of 77 patients, with 30 cases of RO (39%) and 47 cases of ccRCC (61%). Radiomic features were extracted both from the tumor volumes identified by the clinicians and from the tumor’s zone of transition (ZOT). We used a genetic algorithm to perform feature selection, identifying the most descriptive set of features for the tumor classification. We built a decision tree classifier to distinguish between ROs and ccRCCs. We proposed two versions of the pipeline: in the first one, the feature selection was performed before the splitting of the data, while in the second one, the feature selection was performed after, i.e., on the training data only. We evaluated the efficiency of the two pipelines in cancer classification. Results: The ZOT features were found to be the most predictive by the genetic algorithm. The pipeline with the feature selection performed on the whole dataset obtained an average ROC AUC score of 0.87 ± 0.09. The second pipeline, in which the feature selection was performed on the training data only, obtained an average ROC AUC score of 0.62 ± 0.17. Conclusions: The obtained results confirm the efficiency of ZOT radiomic features in capturing the renal tumor characteristics. We showed that there is a significant difference in the performances of the two proposed pipelines, highlighting how some already published radiomic analyses could be too optimistic about the real generalization capabilities of the models.

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Percutaneous tumor ablation versus partial nephrectomy for small renal mass: the impact of histologic variant and tumor size

Cited by 14 publications

References 28 publications

RETRACTED: Meta analysis of clinical prognosis of radiofrequency ablation versus partial nephrectomy in the treatment of early renal cell carcinoma

RETRACTED: Meta analysis of clinical prognosis of radiofrequency ablation versus partial nephrectomy in the treatment of early renal cell carcinoma

Clinical and Oncological Outcomes Following Percutaneous Cryoablation vs. Partial Nephrectomy for Clinical T1 Renal Tumours: Systematic Review and Meta-Analysis

Effectiveness of Radiomic ZOT Features in the Automated Discrimination of Oncocytoma from Clear Cell Renal Cancer

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