Perfluorooctane sulfonate (PFOS) can alter the hypothalamic–pituitary–adrenal (HPA) axis activity by modifying CRF1 and glucocorticoid receptors

Salgado-Freiría, R.; López-Doval, S.; Lafuente, A.

doi:10.1016/j.toxlet.2018.05.025

Cited by 24 publications

(19 citation statements)

References 57 publications

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“…Water-repellent textiles and paper products; fire-fighting foams, skiing wax, cosmetics, impregnation agents Disrupted gene expression of StAR, CYP, HSD, MC2R ; ↑ 17-OHpregnenolone, ↑ DHEA; ↓ cortisol, ↓ corticosterone, ↓ aldosterone [48]; ↓ serum GC, ↓ ACTH, ↓ CRH [70]; ↑ serum CBG [80]; ↓ central expression of CRHR, GR [70] Alkylphenols Octylphenol (OP), Nonylphenol (NP) OP Detergents, additives in fuels, lubricants; found in fragrances, tires, adhesives, coatings, carbonless copy paper, rubber products.…”

Section: Bisphenolsmentioning

confidence: 99%

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Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

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Endocrine-disrupting chemicals (EDCs) are exogenous substances known to interfere with endocrine homeostasis and promote adverse health outcomes. Their impact on the adrenal cortex, corticosteroids and their physiological role in the organism has not yet been sufficiently elucidated. In this review, we collect experimental and epidemiological evidence on adrenal disruption by relevant endocrine disruptors. In vitro data suggest significant alterations of gene expression, cell signalling, steroid production, steroid distribution, and action. Additionally, morphological studies revealed disturbances in tissue organization and development, local inflammation, and zone-specific hyperplasia. Finally, endocrine circuits, such as the hypothalamic-pituitary-adrenal axis, might be affected by EDCs. Many questions regarding the detection of steroidogenesis disruption and the effects of combined toxicity remain unanswered. Not only due to the diverse mode of action of adrenal steroids and their implication in many common diseases, there is no doubt that further research on endocrine disruption of the adrenocortical system is needed.

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Section: Bisphenolsmentioning

confidence: 99%

“…Suppression (e.g. in the presence of tributyltin, PFOS) [69][70][71] or elevation (e.g. in the presence of BDE-47, octyl-/nonylphenol, BPA) [59,[72][73][74][75]36] of corticosterone levels was induced by a significant number of administered endocrine disruptors in animals.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

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“…Direct hypothalamic-pituitary-adrenal axis involvement with EDCs is still a matter of debate due to the lack of evidence, especially in human species. A few animal studies reported a direct suppression of this axis through a reduction in adrenocorticotrophic hormone (ACTH) and corticosterone levels after PCBs exposition [ 49 ], chiefly in female rats [ 50 ], or indirectly through reduction of hypothalamic corticosterone-releasing-factor mRNA [ 51 ]. BPA increased ACTH and corticosterone levels in male, but not in female rats [ 52 ].…”

Section: Pituitary Glandmentioning

confidence: 99%

Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands

et al. 2022

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Background In recent years, scientific research has increasingly focused on Endocrine Disrupting Chemicals (EDCs) and demonstrated their relevant role in the functional impairment of endocrine glands. This induced regulatory authorities to ban some of these compounds and to carefully investigate others in order to prevent EDCs-related conditions. As a result, we witnessed a growing awareness and interest on this topic. Aims This paper aims to summarize current evidence regarding the detrimental effects of EDCs on pivotal endocrine glands like pituitary, thyroid and adrenal ones. Particularly, we directed our attention on the known and the hypothesized mechanisms of endocrine dysfunction brought by EDCs. We also gave a glimpse on recent findings from pioneering studies that could in the future shed a light on the pathophysiology of well-known, but poorly understood, endocrine diseases like hormone-producing adenomas. Conclusions Although intriguing, studies on endocrine dysfunctions brought by EDCs are challenging, in particular when investigating long-term effects of EDCs on humans. However, undoubtedly, it represents a new intriguing field of science research.

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“…Experimental evidences that developmental exposure to perfluorosulfonates induce neuroendocrine disturbances and neurodevelopmental delays have been reported (Austin et al, 2003;Lau et al, 2003). Exposure to these molecules lead to spontaneous hyperactivity in zebrafish, disrupt hippocampal cells in mice, and alter the hypothalamic-pituitary-adrenal axis in rats (Long et al, 2013;Spulber et al, 2014;Salgado-Freiria et al, 2018). In human, recent epidemiological data showed that high levels of perfluoroalkyl acids is associated with behavioral difficulties in 7-year old children (Oulhote et al, 2016).…”

Section: Introductionmentioning

confidence: 99%