Perforated emphysematous cholecystitis and Streptococcus bovis

Mora-Guzmán, Ismael; Martín-Pérez, Elena

doi:10.17235/reed.2018.5826/2018

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Alphadiversity serves as an indicator to measure species diversity within an ecosystem or community, while β-diversity metrics reveal relative differences in microbial communities between patients with acute and chronic cholecystitis [35]. Mora-Guzmán I et al and Mintz D et al found that there are differences in microbial profiles in the bile of cholecystitis patients compared to healthy individuals, with lower richness and diversity in patient microbiota [36,37]. Similarly, in our study, we observed lower bacterial diversity and richness in the Acute group compared to the Chronic group, accompanied by significant alterations in microbial composition between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Altered microbiome of serum exosomes in patients with acute and chronic cholecystitis

Zhu,

Li,

et al. 2024

BMC Microbiol

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Background This study aimed to investigate the differences in the microbiota composition of serum exosomes from patients with acute and chronic cholecystitis. Method Exosomes were isolated from the serum of cholecystitis patients through centrifugation and identified and characterized using transmission electron microscopy and nano-flow cytometry. Microbiota analysis was performed using 16S rRNA sequencing. Results Compared to patients with chronic cholecystitis, those with acute cholecystitis exhibited lower richness and diversity. Beta diversity analysis revealed significant differences in the microbiota composition between patients with acute and chronic cholecystitis. The relative abundance of Proteobacteria was significantly higher in exosomes from patients with acute cholecystitis, whereas Actinobacteria, Bacteroidetes, and Firmicutes were significantly more abundant in exosomes from patients with chronic cholecystitis. Furthermore, functional predictions of microbial communities using Tax4Fun analysis revealed significant differences in metabolic pathways such as amino acid metabolism, carbohydrate metabolism, and membrane transport between the two patient groups. Conclusions This study confirmed the differences in the microbiota composition within serum exosomes of patients with acute and chronic cholecystitis. Serum exosomes could serve as diagnostic indicators for distinguishing acute and chronic cholecystitis.

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Section: Discussionmentioning

confidence: 99%

Altered microbiome of serum exosomes in patients with acute and chronic cholecystitis

Zhu,

Li,

et al. 2024

BMC Microbiol

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“…Serious infections are uncommon but have a high mortality rate [49]. There are S. equinus infections in newborns and infants -sepsis and meningitis [50,51]. A French study covering the period 2012-2017 found 16 cases of infective endocarditis due to S. equinus [52].…”

Section: Streptococcus Equinusmentioning

confidence: 99%

“…There are S. equinus infections in newborns and infants – sepsis and meningitis [50, 51]. A French study covering the period 2012–2017 found 16 cases of infective endocarditis due to S.…”

Section: Introductionmentioning

confidence: 99%

Pathogenicity and drug resistance of animal streptococci responsible for human infections

Glajzner

Szewczyk

Szemraj

2021

Journal of Medical Microbiology

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Bacteria of the genus Streptococcus , earlier considered typically animal, currently have also been causing infections in humans. It is necessary to make clinicians aware of the emergence of new species that may cause the development of human diseases. There is an increasing frequency of isolation of streptococci such as S. suis , S. dysgalactiae , S. iniae and S. equi from people. Isolation of Streptococcus bovis/Streptococcus equinus complex bacteria has also been reported. The streptococcal species described in this review are gaining new properties and virulence factors by which they can thrive in new environments. It shows the potential of these bacteria to changes in the genome and the settlement of new hosts. Information is presented on clinical cases that concern streptococcus species belonging to the groups Bovis, Pyogenic and Suis. We also present the antibiotic resistance profiles of these bacteria. The emerging resistance to β-lactams has been reported. In this review, the classification, clinical characteristics and antibiotic resistance of groups and species of streptococci considered as animal pathogens are summarized.

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“…The rare emphysematous variant is associated with less than 3% of cholecystitis cases with a mortality rate of 15%-20% in comparison to the 1.4% mortality in patients with cholecystitis. It should be noted that patients with EC may also have concurrent gallstones [2,3]. The underlying etiology is thought to be infection resulting in gangrene and subsequent necrosis of the gallbladder.…”

Section: Introductionmentioning

confidence: 99%

Emphysematous Cholecystitis Secondary to Fusobacterium nucleatum

Kunadia¹,

Leong²,

Komanduri³

et al. 2021

Cureus

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Fusobacterium nucleatum may be implicated in cases of emphysematous cholecystitis (EC) and carries a high mortality risk, especially in individuals with heart disease, renal insufficiency, and underlying malignancy. Fusobacterium infections are rarely detected in the setting of cholecystitis possibly due to the difficulty with properly culturing the bacteria. We describe a case of a patient with EC in whom blood cultures were positive for growth of F. nucleatum in one of two samples. The patient was treated with empiric antibiotic therapy consisting of metronidazole and cefepime. In patients with EC and negative cultures, it is possible that they may have an undetected infection with fusobacteria, which carries a high mortality risk. As such, clinicians should maintain a high degree of suspicion of obligate anaerobic infection in patients who have negative blood culture for growth in the setting of EC and consider continuation of adequate antimicrobial coverage.

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Perforated emphysematous cholecystitis and Streptococcus bovis

Cited by 3 publications

References 5 publications

Altered microbiome of serum exosomes in patients with acute and chronic cholecystitis

Altered microbiome of serum exosomes in patients with acute and chronic cholecystitis

Pathogenicity and drug resistance of animal streptococci responsible for human infections

Emphysematous Cholecystitis Secondary to Fusobacterium nucleatum

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