Performance characterization of a novel electronic number connection test to detect minimal hepatic encephalopathy in cirrhotic patients

Wuensch, Tilo; Ruether, Darius Ferenc; Zöllner, Caroline; Müller, Tobias; Jung, Tobias; Kaffarnik, Magnus; Kassner, Ursula; Schott, Eckart; Kiefer, Stephan; Pratschke, Johann; Stockmann, Martin; Jara, Maximilian

doi:10.1097/meg.0000000000000806

Cited by 13 publications

(13 citation statements)

References 24 publications

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“…Wuensch et al found that the eNCT performance was negatively correlated with PHES performance in patients with cirrhosis. Control participants showed significantly faster eNCT completion times compared with cirrhosis patients (Wuensch et al 2017 ).…”

Section: Diagnosis Of Mhe: Cognitive Evaluationmentioning

confidence: 99%

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

et al. 2020

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Minimal hepatic encephalopathy (MHE), which shows mild cognitive impairment, is a subtle complication of cirrhosis that has been shown to affect daily functioning and quality of life. However, until 2014, relevant guidelines do not give much attention to the diagnosis and treatment of MHE, resulting in patients being ignored and denied the benefits of treatment. In this review, we summarize recent cognition-based research about (1) alteration of nerve cells, including astrocytes, microglial cells and neurons, in mild cognitive impairment in MHE; (2) comparison of methods in detecting cognitive impairment in MHE; and (3) comparison of methods for therapy of cognitive impairment in MHE. We hope to provide information about diagnosis and treatment of cognitive impairment in patients with MHE.

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Section: Diagnosis Of Mhe: Cognitive Evaluationmentioning

confidence: 99%

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

et al. 2020

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“…This study indicated that the computerized Stroop test is suitable for MHE screening in children. Moreover, Wuensch et al[ 55 ], who was inspired by the paper-pencil number connection test version A, developed a novel electronic number connection test. The electronic number connection test exhibited high sensitivity (> 82%) and high speciﬁcity (> 85%) in MHE detection with excellent test–retest reliability.…”

Section: Other Modalitiesmentioning

confidence: 99%

Novel computerized psychometric tests as primary screening tools for the diagnosis of minimal hepatic encephalopathy

Luo¹,

Mu²,

Liu³

et al. 2020

WJCC

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Minimal hepatic encephalopathy (MHE) is a critical neurocognitive complication of decompensated liver cirrhosis and portosystemic shunting, which results in a wide range of cognitive deficits including impairments in working attention, psychomotor speed, and executive function. Current guidelines have recommended paper-and-pencil psychometric tests for the diagnosis of MHE. Most high-risk cirrhotic patients are required to be examined; however, paper-and-pencil psychometric tests are neither convenient nor rapid to perform in the clinic. Recently, novel computerized psychometric tests, including the inhibitory control test, EncephalApp Stroop App, and critical flicker frequency, have been proven to be rapid, effective, and convenient methods for screening MHE in clinical practice and for identifying high-risk cirrhotic patients for further validation using rigid neuropsychometric examinations. However, diagnostic accuracy of these tests is influenced by educational background, age, and cultural differences. This review summarizes clinical evidence of the application of novel computerized psychometric tests for screening MHE.

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“…Apart from PHES, a newly developed electronic number connection test (eNCT) was investigated by Wuensh et al . 87 . This test flashes the numbers 1–25 on a screen and requires the participant to click them in order while being timed; those patients with HE were found to be much slower 87 .…”

Section: Recent Advances In the Diagnosis Of Hepatic Encephalopathymentioning

confidence: 99%

“… 87 . This test flashes the numbers 1–25 on a screen and requires the participant to click them in order while being timed; those patients with HE were found to be much slower 87 . This test promises to be an easier and faster method than PHES 87 .…”

Section: Recent Advances In the Diagnosis Of Hepatic Encephalopathymentioning

confidence: 99%

Recent advances in hepatic encephalopathy

2017

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Hepatic encephalopathy describes the array of neurological alterations that occur during acute liver failure or chronic liver injury. While key players in the pathogenesis of hepatic encephalopathy, such as increases in brain ammonia, alterations in neurosteroid levels, and neuroinflammation, have been identified, there is still a paucity in our knowledge of the precise pathogenic mechanism. This review gives a brief overview of our understanding of the pathogenesis of hepatic encephalopathy and then summarizes the significant recent advances made in clinical and basic research contributing to our understanding, diagnosis, and possible treatment of hepatic encephalopathy. A literature search using the PubMed database was conducted in May 2017 using “hepatic encephalopathy” as a keyword, and selected manuscripts were limited to those research articles published since May 2014. While the authors acknowledge that many significant advances have been made in the understanding of hepatic encephalopathy prior to May 2014, we have limited the scope of this review to the previous three years only.

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Performance characterization of a novel electronic number connection test to detect minimal hepatic encephalopathy in cirrhotic patients

Abstract: The novel eNCT is a reliable HE self-test to monitor cognitive function and detect cognitive impairment in cirrhotic patients.

Cited by 13 publications

References 24 publications

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy

Novel computerized psychometric tests as primary screening tools for the diagnosis of minimal hepatic encephalopathy

Recent advances in hepatic encephalopathy

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