Performance evaluation of cylindrical fiber optic light diffusers for biomedical applications

Vesselov, Leonid; Whittington, William L. H.; Lilge, Lothar

doi:10.1002/lsm.20031

Cited by 44 publications

(43 citation statements)

References 20 publications

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“…1). The component is made by mixing either aluminum dioxide powder (1μm in diameter, SA-32, Tyng Hang Industrial Co. Ltd., Taiwan) or optical diffuse powder (2μm in diameter, HSP-200, Sau Inc., Taiwan) with UV (ultraviolet) gel (Norland 61, Norland Products Inc., USA) [16,17]. The ratio (in weight) of the powder to the UV gel is approximately 7%~10%.…”

Section: The Quality Of Illuminationmentioning

confidence: 99%

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Supercontinuum as a light source for miniaturized endoscopes

Lu¹,

Lin²,

Hsieh³

et al. 2016

Biomed. Opt. Express

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Abstract:In this work, we have successfully implemented supercontinuum based illumination through single fiber coupling. The integration of a single fiber illumination with a miniature CMOS sensor forms a very slim and powerful camera module for endoscopic imaging. A set of tests and in vivo animal experiments are conducted accordingly to characterize the corresponding illuminance, spectral profile, intensity distribution, and image quality. The key illumination parameters of the supercontinuum, including color rendering index (CRI: 72%~97%) and correlated color temperature (CCT: 3,100K~5,200K), are modified with external filters and compared with those from a LED light source (CRI~76% & CCT~6,500K). The very high spatial coherence of the supercontinuum allows high luminosity conduction through a single multimode fiber (core size~400μm), whose distal end tip is attached with a diffussion tip to broaden the solid angle of illumination (from less than 10° to more than 80°).

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Section: The Quality Of Illuminationmentioning

confidence: 99%

“…3(b)). Note that the full width at half maximum (FWHM) is used to characterize the illumination angles from the LIDC [16,17,20]. In both cases the intensity achieved is greater than the sensitivity threshold of the CMOS camera module.…”

Section: The Quality Of Illuminationmentioning

confidence: 99%

Supercontinuum as a light source for miniaturized endoscopes

Lu¹,

Lin²,

Hsieh³

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…12 In an attempt to obtain homogeneous light distribution, an optical diffuser has been developed and evaluated for endometrial ablation. [14][15][16][17][18] The diffuser was created by removing the cladding and adding a diffusing medium such as silicon and scattering particles on the core surface. However, the applied power level (≤25 W) was relatively lower than the requirement for surgical tissue removal, in that most applications were related to photodynamic therapy (PDT).…”

Section: Introductionmentioning

confidence: 99%

Enhanced photocoagulation with catheter-based diffusing optical device

Kang

Kim

2012

J. Biomed. Opt

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Abstract. A novel balloon catheter-based diffusing optical device was designed and evaluated to assist in treating excessive menstrual bleeding. A synthetic fused-silica fiber was micro-machined precisely to create scattering segments on a 25 mm long fiber tip for uniform light distribution. A visible wavelength (λ ¼ 532 nm) was used to specifically target the endometrium due to the high vascularity of the uterine wall. Optical simulation presented 30% wider distribution of photons along with approximately 40% higher irradiance induced by addition of a glass cap to the diffuser tip. Incorporation of the optical diffuser with a polyurethane balloon catheter considerably enhanced coagulation depth and area (i.e., 3.5 mm and 18.9 cm 2 at 1 min irradiation) in tissue in vitro. The prototype device demonstrated the coagulation necrosis of 2.8 AE 1.2 mm (n ¼ 18) and no thermal damage to myometrium in in vivo caprine models. A prototype 5 cm long balloon catheter-assisted optical diffuser was also evaluated with a cadaveric human uterus to confirm the coagulative response of the uterine tissue as well as to identify the further design improvement and clinical applicability. The proposed catheter-based diffusing optical device can be a feasible therapeutic tool to photocoagulate endometrial cell layers in an efficient and safe manner.

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“…12,16 In addition to the axial and circumferential (azimuthal) directions, measurement of the polar radiance distribution has been performed to provide a more thorough assessment of the diffuser emission. [17][18][19] We have developed a technique for constructing high-power light diffusing devices comprised of a flexible shape memory polymer (SMP) cylindrical diffuser attached to the tip of an optical fiber. These diffusers were initially developed to provide a means of photothermal actuation for the devices mentioned previously, 8-10 though other applications are possible.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of cylindrical light diffusers comprised of shape memory polymer

et al. 2008

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We developed a technique for constructing light diffusing devices comprised of a flexible shape memory polymer (SMP) cylindrical diffuser attached to the tip of an optical fiber. The devices are fabricated by casting an SMP rod over the cleaved tip of an optical fiber and media blasting the SMP rod to create a light diffusing surface. The axial and polar emission profiles and circumferential (azimuthal) uniformity are characterized for various blasting pressures, nozzle-to-sample distances, and nozzle translation speeds. The diffusers are generally strongly forward-directed and consistently withstand over 8 W of incident IR laser light without suffering damage when immersed in water. These devices are suitable for various endoluminal and interstitial biomedical applications.

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Performance evaluation of cylindrical fiber optic light diffusers for biomedical applications

Abstract: To enable light dosimetry and treatment planning for applications such as photodynamic therapy or interstitial laser hyperthermia or photocoagulation, standardization of emission properties reporting for optical fiber diffusers is required.

Cited by 44 publications

References 20 publications

Supercontinuum as a light source for miniaturized endoscopes

Supercontinuum as a light source for miniaturized endoscopes

Enhanced photocoagulation with catheter-based diffusing optical device

Fabrication and characterization of cylindrical light diffusers comprised of shape memory polymer

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