Performance evaluation of non-ionic surfactant based tazarotene encapsulated proniosomal gel for the treatment of psoriasis

Prasad, Vure; Chaurasia, Sundeep

doi:10.1016/j.msec.2017.05.036

Cited by 29 publications

(14 citation statements)

References 44 publications

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“…In another study tazarotene, proniosomal gel was developed by Prasad and Chaurasia, where they developed the proniosomes employing coacervation phase separation composed of stearylamine, span, lecithin, and cholesterol for topical delivery [48]. Span 60 was determined to yield high efficiency for encapsulation.…”

Section: Concise Evidence Of Published Proniosomal Gel Formulations Amentioning

confidence: 99%

Recent Update on Proniosomal Gel as Topical Drug Delivery System

Rajkumar

Sastri

et al. 2019

Asian J Pharm Clin Res

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An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

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Section: Concise Evidence Of Published Proniosomal Gel Formulations Amentioning

confidence: 99%

Recent Update on Proniosomal Gel as Topical Drug Delivery System

Rajkumar

Sastri

et al. 2019

Asian J Pharm Clin Res

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“…At sampling intervals of 30 min for 6 h, 1 mL sample was withdrawn and replaced by equal volumes of fresh medium to maintain sink condition. The samples were diluted to10 mL with phosphate buffer pH 5.5 and filtered using Whatman filter paper (0.45 µm) and analyzed by HPLC 28,29 .…”

Section: Determination Of Drug Contentmentioning

confidence: 99%

Formulation and Evaluation of Topical Formulation for Cutaneous Tuberculosis

Rao¹,

Kadam²,

Rao³

2018

J. Drug Delivery Ther.

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Cutaneous Tuberculosis is also known as dermal tuberculosis or tuberculosis cutis (extrapulmonary tuberculosis) which can occur in any age group and patients who may or may not be suffering from pulmonary tuberculosis. The current treatment given for the disease is oral therapy of anti-tubercular drugs which has many side effects such as hepatotoxicity, headache, anxiety, euphoria, insomnia, eosinophilia, hepatitis. Hence to avoid these side effects and to increase efficiency of current therapy a topical proniosomal gel of isoniazid was formulated. Coacervation phase separation method was used and proniosomal gel was formulated by using Span 20, soya lecithin, and cholesterol. Optimum concentration of 3 factors Span 20, soya lecithin, and cholesterol were determined using Box Behnken design with at 2 levels and vesicle size and entrapment efficiency as responses. The optimized proniosomal gel was characterized by vesicle size, entrapment efficiency, transmission electron microscopy (TEM), in vitro drug release, skin retention studies, skin irritation studies and stability studies. The optimised batch showed vesicle size of 2.27±1.82 µ, and entrapment efficiency of 98.15±0.25 %. The optimised formulation was stable under refrigeration condition (5°C) in amber coloured bottle, was non-irritating and showed 98.10±1.28 % release and 85±1.53 % permeation after 6 h and 436±12 µg drug was retained in the skin after 3 hrs.

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“…Human skin is the important target site for the application of drug especially in the treatment of local disease. Penetration enhancement with special formulation approaches is mainly based on the usage of colloidal carriers [1]. Colloidal carrier have distinct advantages over conventional drug delivery as it act as drug containing reservoirs, modification of the particle composition or surface can adjusts the release rate to the target site [2].…”

Section: Introductionmentioning

confidence: 99%

“…A number of vesicles systems such as liposomes, niosomes, ethosomes, emulsomes and transfersomes have been developed. The vesicular carrier such as niosomes has distinct advantage over conventional dosage forms because these particles can act as drug reservoir [1][2].…”

Section: Introductionmentioning

confidence: 99%

Formulation and in Vitro, in Vivo Evaluation of Proniosomal Gel of Neomycin Sulphate

Shete

Thorat²,

Doijad

et al. 2019

Int J App Pharm

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Objective: The objectives of present investigation were to prepare and evaluate proniosomes of neomycin sulphate (NS) by coacervation phase separation method by using sorbitan monostearate (span 60) and lecithin as a surfactant to increase the penetration through the skin and study the effect of concentration of the same. Methods: Proniosomes of neomycin sulphate (NS) were prepared by coacervation phase separation method by using span 60 and lecithin. The effect of concentration of span 60 and lecithin was studied by factorial design. The prepared proniosomes were converted to gel by using carbopol as a gelling agent. The prepared formulations were evaluated for entrapment efficiency, in vitro drug diffusion, in vitro antibacterial activity and in vivo skin irritation test etc. Results: All Formulation showed the percentage entrapment efficiency in the range 38.31±0.05% to 77.96±0.06%, good homogeneity and gel was easily spreadable with minimal of shear. Optimized formulation showed enhanced rate of diffusion in vitro, increase in zone of inhibition against staphylococcus aureus, no skin irritation and showed good stability. Conclusion: The results of present study indicates that proniosomal gel formulated by using combination of span 60, Lecithin, cholesterol can be used to enhance skin delivery of NS because of excellent permeation of drug. Developed proniosomal gel formulation was promising carrier for NS

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Performance evaluation of non-ionic surfactant based tazarotene encapsulated proniosomal gel for the treatment of psoriasis

Cited by 29 publications

References 44 publications

Recent Update on Proniosomal Gel as Topical Drug Delivery System

Recent Update on Proniosomal Gel as Topical Drug Delivery System

Formulation and Evaluation of Topical Formulation for Cutaneous Tuberculosis

Formulation and in Vitro, in Vivo Evaluation of Proniosomal Gel of Neomycin Sulphate

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